The Placental Role in Gestational Diabetes Mellitus: A Molecular Perspective
María José Calvo,
Heliana Parra,
Raquel Santeliz
et al.
Abstract:During pregnancy, women undergo several metabolic changes to guarantee an adequate supply of glucose to the foetus. These metabolic modifications develop what is known as physiological insulin resistance. When this process is altered, however, gestational diabetes mellitus (GDM) occurs. GDM is a multifactorial disease, and genetic and environmental factors play a crucial role in its aetiopathogenesis. GDM has been linked to both macroscopic and molecular alterations in placental tissues that affect placental p… Show more
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