The Placenta in Maternal Disorders

Fox, H.; Sebire, Neil J

doi:10.1016/b978-1-4160-2592-4.50013-8

Cited by 6 publications

(3 citation statements)

References 251 publications

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“…According to Fox 25 , Jones 26 and Soma et al 27 , the histomorphological abnormalities in hypertensive placenta are due to occlusion or narrowing of the uteroplacental vessels as well as placental ischemia. In pre-eclampsia the balance between formation of free radicals, and antioxidant mediated defense is disrupted, leading to abnormalities of endothelial function and free radical-mediated endothelial cell injury.…”

Section: Discussionmentioning

confidence: 99%

Histopathological Study of Full-Term Placenta in Selected Normotensive And Pre-eclamptic Women in Bangladesh

Khan¹,

Nahid²,

Chowdhury³

et al. 2023

J Dhaka Med Coll

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Pre-eclampsia is a disorder of 2nd half of pregnancy, which is characterized by a combination of hypertension, proteinuria and edema, secondary to decreased placental perfusion. Clinical studies suggest that there are histopathological changes in the placenta of pre-eclamptic women, compared to normotensive pregnant women. In developing countries, pre-eclampsia causes an estimated 50,000 maternal deaths per year. Only a small number of studies have however, been conducted in Bangladesh. Objective: To compare the histopathology of placenta in selected pre-eclamptic and normotensive pregnant women. Methods: 220 pregnant women were selected with inclusion and exclusion criteria from 3 different medical colleges and divided into 2 groups – A study group, consisting of 110 pre-eclamptic women and a control group consisting of 110 normotensive pregnant women. Dietary information was collected by 7 days food frequency questionnaire and food score was determined. Anthropometric and biochemical tests were performed. To evaluate the histopathology of placenta, tissue samples were collected from the placenta after delivery, and were prepared for histopathological studies, by haemotoxylin and eosin stain method. The mean number of areas of syncytial knot formation, the mean number of areas of cytotrophoblastic cell proliferation, the mean number of areas of fibrinoid necrosis, and the mean number of areas of hyalinised villi of pre-eclamptic and normal pregnant women were evaluated. Results: The mean number of areas of syncytial knot formation, the mean number of areas of cytotrophoblastic cell proliferation, the mean number of areas of fibrinoid necrosis, and the mean number of areas of hyalinised villi were found to be significantly higher in the study group, compared to the control group. Conclusion: Therefore, mean number of areas of syncytial knot formation, the mean number of areas of cytotrophoblastic cell proliferation, the mean number of areas of fibrinoid necrosis is increased in the placenta of pre-eclamptic women, compared to normotensive pregnant women. J Dhaka Med Coll. 2021; 30(2) : 189-195

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Section: Discussionmentioning

confidence: 99%

Histopathological Study of Full-Term Placenta in Selected Normotensive And Pre-eclamptic Women in Bangladesh

Khan¹,

Nahid²,

Chowdhury³

et al. 2023

J Dhaka Med Coll

View full text Add to dashboard Cite

show abstract

“…This study indicates that the mean placental weight in pre-eclamptic women was less (404. Many foreign studies have shown the effect of Hypertensive disorders of pregnancy on the placental weight and the overall status of the mother and the baby; they reported a moderate to severe reduction of placental weight in preeclampsia and eclampsia 29,30,25,31 . Cibils 24 studied pregnancy outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…Shah et al 23 found that mean weight decreases with increasing severity of toxemia. Fox 29 attributed abnormal maternal uteroplacental vasculature to weight reduction. Soma et al 30 also stated that it must be assumed that morphological and histological findings in the hypertensive placenta are due to occlusion or narrowing of the uteroplacental vasculature and placental ischemia.…”

Section: Discussionmentioning

confidence: 99%

Histo-Morphogical Study of Full- Term Placenta in Selected Normotensive And Pre-eclamptic Women in Bangladesh

Khan,

Nahid,

Choudhury

2023

J Dhaka Med Coll

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Pre–Eclampsia is a disorder in 2nd half of pregnancy, characterized by a combination of hypertension, proteinuria, and edema, secondary to decreased placental perfusion. Clinical studies suggest histo-morphological changes in the placenta of pre-eclamptic women compared to normotensive pregnant women. This study aimed to compare the histo- morphological changes of the placenta in selected pre-eclamptic and normotensive pregnant women. Methods: Two hundred twenty pregnant women were selected with inclusion and exclusion criteria from 3 different medical colleges and divided into two groups. A study group comprised 110 pre-eclamptic women, and a control group comprised 110 normotensive pregnant women. After delivery, tissue samples were collected from the placenta and prepared for histopathological studies by hematoxylin and eosin stain. The mean number of areas of syncytial knot formation, the mean number of areas of cytotrophoblast cell proliferation, the mean number of areas of fibrinoid necrosis, and the mean number of areas of hyalinized villi of pre-eclamptic and normal pregnant women were evaluated. We evaluated the morphology by weight, diameters, number of cotyledons, and placental infarcts. Results: The mean number of areas of syncytial knot formation, cytotrophoblastic cell proliferation, fibrinoid necrosis, and hyalinised villi were significantly higher in the study group compared to the control group. The mean weights, diameters, and the number of cotyledons were considerably lower in the study group compared to the control group. Moreover, the number of infarcted areas was significantly higher in the placentas of pre-eclamptic women. Conclusion: There are histomorphologic changes in the placenta of pre-eclamptic women. J Dhaka Med Coll. 2022; 31(1) : 37-45

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Placental Findings Contributing to Perinatal Death: A 15-Year Retrospective Review from a Teaching Hospital in Thailand

Taweevisit

Thorner

2020

Fetal and Pediatric Pathology

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The Placenta in Maternal Disorders

Cited by 6 publications

References 251 publications

Histopathological Study of Full-Term Placenta in Selected Normotensive And Pre-eclamptic Women in Bangladesh

Histopathological Study of Full-Term Placenta in Selected Normotensive And Pre-eclamptic Women in Bangladesh

Histo-Morphogical Study of Full- Term Placenta in Selected Normotensive And Pre-eclamptic Women in Bangladesh

Placental Findings Contributing to Perinatal Death: A 15-Year Retrospective Review from a Teaching Hospital in Thailand

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