"The Place of Osteoimmunology in the Pathogenesis of Rheumatic Joint and Bone Diseases"

Abstract

The bone and immune cells all share the same microenvironment, interact with each other, share common signaling pathways, collaborate, performing the functions of an "osteoimmune system". The same cytokines may have different and often opposite effects depending on the specific environment in which they function, the maturation stage of the target cells and/or the influence of other cytokines. Through osteoimmunology, the intimate mechanisms in the pathogenesis of many rheumatological diseases such as Rheumatoid arthritis, axSpA, autoinflammatory diseases, osteonecrosis, osteoarthrosis, osteoporosis are clarified. Osteoimmunology is a conceptual framework for decoding the complex language through which the immune system and bone communicate. This review summarizes the data accumulated to date on the interactions between the immune and bone systems of the human organism and reveals the bidirectionality of these interactions and their role in the pathogenesis of rheumatic joint and bone diseases.