The place of hyperbaric oxygen therapy and ozone therapy in sudden hearing loss

Taşdöven, Gülin Ergun; Derin, Alper Tunga; Yaprak, Neslihan; Özçağlar, Hasan Ümit

doi:10.1016/j.bjorl.2016.06.002

Cited by 10 publications

(8 citation statements)

References 22 publications

(23 reference statements)

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“…Ten suitable trials involving 1295 patients were retrieved (Table 3) [17–25]. A study conducted by Topuz et al, demonstrated an average of the hearing gain at five contiguous frequencies significantly higher in the HBO + SS group for patients with severe or profound hearing impairment (respectively, p = 0.014 and p = 0.005) [15].…”

Section: Resultsmentioning

confidence: 99%

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The effectiveness of hyperbaric oxygen in patients with idiopathic sudden sensorineural hearing loss: a systematic review

Eryigit

Ziylan

Yaz

et al. 2018

Eur Arch Otorhinolaryngol

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ObjectiveTo evaluate the effectiveness of hyperbaric oxygen in the treatment of patients with idiopathic sudden sensorineural hearing loss (ISSHL).Data sourcesAn Embase, MEDLINE and Cochrane search were utilised to identify various clinical trials on the treatment of ISSHL. Studies that were published between 2002 and 2018 and written in the English, Dutch or German language were included. Search terms included synonyms for idiopathic sudden hearing loss.Data synthesisA total of 16 articles were identified regarding hyperbaric oxygen therapy. All patients were evaluated with pure-tone audiometry. A major part of the cases presented with unilateral hearing loss(bilateral hearing loss less than 5%). In several studies, the average of the mean hearing gain at five contiguous frequencies was significantly higher in the hyperbaric oxygen (HBO) therapy and systemic steroid (SS) group in patients with severe or profound hearing impairment. They recorded a significant treatment effect (p = 0.005) of HBO + SS therapy on patients with an initial hearing loss of ≥ 81 dB.ConclusionsOn the whole group of ISSHL patients, no significant difference was demonstrated between the intervention and control group. However, in severe or profound hearing-impaired ISSHL patients, significant benefit was observed in the intervention group. These results likely indicate that adding HBO to steroid therapies might be of benefit in cases of severe and profound hearing impairment.

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Section: Resultsmentioning

confidence: 99%

“…Tasdoven et al conducted a trial which indicated that there was no significant difference in the response to treatment between the intervention and control group ( p < 0.355) [17]. However, they found a statistically significant difference in patients who suffered from profound hearing loss.…”

Section: Resultsmentioning

confidence: 99%

The effectiveness of hyperbaric oxygen in patients with idiopathic sudden sensorineural hearing loss: a systematic review

Eryigit

Ziylan

Yaz

et al. 2018

Eur Arch Otorhinolaryngol

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“…However, although many studies have reported that adding HBO to steroid treatment provides additional benefits, there have also been some reports claiming the opposite. In a study comparing three different treatment modalities in ISSHL, it was indicated that although the response rate to oral steroid and oral Steroid+HBO treatment was 50.8% and 61.5%, respectively, there was no significant difference between these two groups in terms of response to treatment [ 20 ]. In a recent study, comparing oral+IT steroid and oral+IT steroid+HBO therapies in ISSHL patients with severe and profound hearing loss (>70 dB), the addition of HBO to steroid combination therapy did not improve the mean PTA values.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Steroid Treatment with and without Hyperbaric Oxygen Therapy for Idiopathic Sudden Sensorineural Hearing Loss

Yücel

Özbuğday²

2020

J Audiol Otol

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Background and Objectives: In this study, we compared the outcomes of patients with idiopathic sudden sensorineural hearing loss who underwent steroid treatment with or without hyperbaric oxygen (HBO) therapy and were followed-up in our clinic.Subjects and Methods: Patients were divided into two groups according to their treatment regimen. Steroid group received intravenous 1 mg/kg methylprednisolone which was due to be completed in 2-3 weeks with decreasing doses, and five doses of 0.5 mL intratympanic dexamethasone. Steroid+HBO group received the same steroid treatment with the addition of HBO therapy. The audiologic results of both treatment groups were compared after considering the patients’ risk factors.Results: There was no significant difference between the steroid and Steroid+HBO groups in terms of hearing gain and degree of recovery, both at all degrees of hearing loss, and in severe and profound hearing loss. Hearing gain was similar when evaluated by audiogram type and admission time in both treatment groups.Conclusions: We found that the addition of HBO therapy to systemic plus intratympanic steroid treatment did not affect hearing gain at all degrees of hearing loss in this study. Furthermore, audiogram type and admission time did not affect hearing gain between the two groups.

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“…Taşdöven et al showed that ozone application, in addition to steroid treatment, gave more successful results than steroids alone in sudden hearing loss. They have linked this to increased oxygen, glucose, and ATP transport to ischemic tissues, and the stimulation of angiogenesis [16]. Leon et al have shown that ozone therapy increases the clinical response of methotrexate in patients with rheumatoid arthritis (RA) receiving methotrexate due to its anti-inflammatory efficacy.…”

Section: Discussionmentioning

confidence: 99%

The effects of ozone therapy on extremity ischemia-reperfusion injury in a rabbit model

Kaymaz

Çoban

Göksel³

et al. 2019

Family Practice and Palliative Care

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Introduction: Ischemia is reversible or irreversible cell/tissue damage that is secondary to insufficient blood flow to tissues or organs. Ischemia causes many metabolic and structural changes at the cellular level. Ozone therapy is often used as an antioxidant remedy. This study aimed to investigate the effects of ozone therapy on extremity ischemia-reperfusion (IR) injury. Methods: Twenty-four New Zealand White (NZW) rabbits were randomly allocated into three groups. Each group consisted of eight rabbits. Group I was the control group, Group II was the ischemia group, and Group III, the ozone group. Femoral arteries of the right legs were dissected, and femoral arterial occlusion was performed in Group II and III. Hematological and histopathological evaluation was performed in all groups. Results: The levels of total antioxidant status (TAS) after the surgical procedure was higher in the ozone group compared to the ischemia group (p=0.036). In addition, the levels of malondialdehyde (MDA) after the surgical procedure were lower in the ozone group compared to the ischemia group but not statistically significant (p=0.093). The control and ozone groups were histopathologically similar. Conclusions: Ozone therapy may be used as an alternative treatment modality with its anti-inflammatory and antioxidant effects for the treatment of extremity IR injury. ÖZGiriş: İskemi; organı veya dokuyu perfüze eden kan akımındaki yetersizliğe bağlı olarak gelişen geri dönüşümlü veya dönüşümsüz hücre/doku zedelenmesidir. İskemi sonrasında hücrelerde pek çok metabolik ve yapısal değişiklikler oluşmaktadır. Ozon (O3) çeşitli hastalıkları tedavisi için antioksidan olarak terapötik amaçlı kullanılmaktadır. Bu çalışmada, ozon tedavisinin ekstremite iskemi-reperfüzyon hasarı üzerine olan etkisinin incelenmesi amaçlanmıştır. Yöntem: 24 adet New Zealand White (NZW) erişkin erkek tavşan rastgele 3 gruba ayrıldı.Grup1: Kontrol grubu (n:8) Grup II: İskemi grubu (n:8) ve Grup III: Ozon grubu (n:8). Deneklerin sağ bacaklarına femoral arter oklüzyonu uygulanıp Grup II ve Grup III de iskemi-reperfüzyon hasarı uygulandı. Kontrol grubunda disseksiyon yapılıp oklüzyon uygulanmadı. Deneklerin kan değerleri ve sakrifikasyon sonrası kas dokusu histopatolojik değerlendirmesi yapıldı. Bulgular: İşlem sonrası iskemi grubuyla ozon tedavisi uygulanan gruplar karşılaştırıldığında; TAS (total antioksidan status) düzeyinin ozon tedavisi uygulanan grupta anlamlı düzeyde daha yüksek (p=0,036) ve MDA (malondialdehit) düzeyinin de ozon tedavisi uygulanan grupta daha düşük olduğu, ancak istatistiksel olarak anlamlılığa (p=0,093) ulaşmadığı görüldü. Histopatolojik açıdan da ozon grubu ile kontrol grubunun benzer olduğu görüldü. Sonuç: Ozon tedavisi güçlü anti-inflamatuvar ve antioksidan etkinliği ile ekstermite iskemi-reperfüzyon (IR) hasarını azaltmada alternatif bir tedavi seçeneği olabilir.

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The place of hyperbaric oxygen therapy and ozone therapy in sudden hearing loss

Abstract: The efficiency of steroid treatment in patients with severe hearing loss was low. It was statistically ascertained that adding hyperbaric oxygen or ozone therapy to the treatment contributed significantly to treatment success.

Cited by 10 publications

References 22 publications

The effectiveness of hyperbaric oxygen in patients with idiopathic sudden sensorineural hearing loss: a systematic review

The effectiveness of hyperbaric oxygen in patients with idiopathic sudden sensorineural hearing loss: a systematic review

Comparison of Steroid Treatment with and without Hyperbaric Oxygen Therapy for Idiopathic Sudden Sensorineural Hearing Loss

The effects of ozone therapy on extremity ischemia-reperfusion injury in a rabbit model

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