2007
DOI: 10.1016/j.bbr.2007.01.015
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The PKC inhibitor, bisindolymaleimide, blocks DOI's attenuation of the effects of 8-OH-DPAT on female rat lordosis behavior

Abstract: Ovariectomized rats with bilateral cannulae near the ventromedial nucleus of the hypothalamus were hormonally primed with 10μg estradiol benzoate and 500μg progesterone. Sexually receptive females were infused bilaterally with 200 ng of the 5-HT 1A receptor agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), or with a combination of 200 ng 8-OH-DPAT and 2000 ng of the 5-HT 2 receptor agonist, (±)-2,5-dimethoxy-4-iodophenyl-2-aminopropane HCl (DOI). 8-OH-DPAT inhibited lordosis behavior and DOI reduce… Show more

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Cited by 3 publications
(2 citation statements)
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References 42 publications
(60 reference statements)
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“…The lordosis-inhibitory effect of 5-HT 1A receptors appear to include inhibition of cAMP-mediated events (Uphouse et al, 2000); and the ability of a 5-HT 2 receptor agonist to attenuate 5-HT 1A receptor-mediated lordosis inhibition is attenuated by inhibition of PKC (Selvamani et al, 2007). Effects of progesterone and/or its metabolite, allopregnanolone, modulate these same signaling events.…”
Section: Discussionmentioning
confidence: 99%
“…The lordosis-inhibitory effect of 5-HT 1A receptors appear to include inhibition of cAMP-mediated events (Uphouse et al, 2000); and the ability of a 5-HT 2 receptor agonist to attenuate 5-HT 1A receptor-mediated lordosis inhibition is attenuated by inhibition of PKC (Selvamani et al, 2007). Effects of progesterone and/or its metabolite, allopregnanolone, modulate these same signaling events.…”
Section: Discussionmentioning
confidence: 99%
“…The vehicle for the MEK inhibitors was 30% DMSO/water. Doses and time course for all inhibitors were based on observations from pilot experiments and previous reports (Bourtchouladze et al 1998; Schafe et al 1999, 2000; Lu et al 2001; Sananbenesi et al 2003; Selvamani et al 2007). ICV infusions were by gravity after which the injector remained in place for 1 min before removal.…”
Section: Methodsmentioning
confidence: 99%