The Pivotal Role of FDG-PET/CT in Modern Medicine

Hess, Søren; Blomberg, Björn Alexander; Zhu, Hongyun; Høilund‐Carlsen, Poul Flemming; Alavi, Abass

doi:10.1016/j.acra.2013.11.002

Cited by 108 publications

(85 citation statements)

References 129 publications

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“…PET is being used with CT and MRI (either sequentially with two separate devices or simultaneously with combined PET-CT or PET-MRI devices) to create fused images providing both structural and functional information. 21 Interventional radiology (IR) uses many of these imaging techniques for minimally invasive surgeries and diagnostic or therapeutic procedures (e.g., cardiac stent placement, laser ablation of fibroids). IR procedures are increasingly being tested and introduced into teleradiology, 5 paralleling the advances in minimally invasive procedures being used in telesurgery, although most applications to date focus on telementoring and tele-education.…”

Section: Modalities Of Teleradiologymentioning

confidence: 99%

The Empirical Foundations of Teleradiology and Related Applications: A Review of the Evidence

Bashshur

Krupiński

Thrall

et al. 2016

Telemedicine and e-Health

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Introduction: Radiology was founded on a technological discovery by Wilhelm Roentgen in 1895. Teleradiology also had its roots in technology dating back to 1947 with the successful transmission of radiographic images through telephone lines. Diagnostic radiology has become the eye of medicine in terms of diagnosing and treating injury and disease. This article documents the empirical foundations of teleradiology. Methods: A selective review of the credible literature during the past decade (2005-2015) was conducted, using robust research design and adequate sample size as criteria for inclusion. Findings: The evidence regarding feasibility of teleradiology and related information technology applications has been well documented for several decades. The majority of studies focused on intermediate outcomes, as indicated by comparability between teleradiology and conventional radiology. A consistent trend of concordance between the two modalities was observed in terms of diagnostic accuracy and reliability. Additional benefits include reductions in patient transfer, rehospitalization, and length of stay.

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Section: Modalities Of Teleradiologymentioning

confidence: 99%

The Empirical Foundations of Teleradiology and Related Applications: A Review of the Evidence

Bashshur

Krupiński

Thrall

et al. 2016

Telemedicine and e-Health

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“…After PET/computed tomography (PET/CT) was used successfully in the primary staging of lung cancer and lymphoma, several new indications in different malignant diseases and therapy response were introduced in clinical routine [2], as well as investigation of nonmalignant diseases such as infections [3,4]. Its main clinical indication continues to be the detection and staging of neoplastic disease [1,5].…”

Section: Introductionmentioning

confidence: 99%

“…PET is a powerful imaging device, which enables imaging and semiquantitative measurement of tracer activity in vivo, and thereby visualizes physiologic and pathophysiologic processes in different organs [1]. After PET/computed tomography (PET/CT) was used successfully in the primary staging of lung cancer and lymphoma, several new indications in different malignant diseases and therapy response were introduced in clinical routine [2], as well as investigation of nonmalignant diseases such as infections [3,4].…”

Section: Introductionmentioning

confidence: 99%

Clinical evaluation of a block sequential regularized expectation maximization reconstruction algorithm in 18F-FDG PET/CT studies

Sah

Stolzmann

Delso

et al. 2017

Nuclear Medicine Communications

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PURPOSE To investigate the clinical performance of a block sequential regularized expectation maximization (BSREM) penalized likelihood reconstruction algorithm in oncologic PET/computed tomography (CT) studies. METHODS A total of 410 reconstructions of 41 fluorine-18 fluorodeoxyglucose-PET/CT studies of 41 patients with a total of 2010 lesions were analyzed by two experienced nuclear medicine physicians. Images were reconstructed with BSREM (with four different values) or ordered subset expectation maximization (OSEM) algorithm with/without time-of-flight (TOF/non-TOF) corrections. OSEM reconstruction postfiltering was 4.0 mm full-width at half-maximum; BSREM did not use postfiltering. Evaluation of general image quality was performed with a five-point scale using maximum intensity projections. Artifacts (category 1), image sharpness (category 2), noise (category 3), and lesion detectability (category 4) were analyzed using a four-point scale. Size and maximum standardized uptake value (SUVmax) of lesions were measured by a third reader not involved in the image evaluation. RESULTS BSREM-TOF reconstructions showed the best results in all categories, independent of different body compartments. In all categories, BSREM non-TOF reconstructions were significantly better than OSEM non-TOF reconstructions (P<0.001). In almost all categories, BSREM non-TOF reconstruction was comparable to or better than the OSEM-TOF algorithm (P<0.001 for general image quality, image sharpness, noise, and P=1.0 for artifact). Only in lesion detectability was OSEM-TOF significantly better than BSREM non-TOF (P<0.001). Both BSREM-TOF and BSREM non-TOF showed a decreasing SUVmax with increasing values (P<0.001) and TOF reconstructions showed a significantly higher SUVmax than non-TOF reconstructions (P<0.001). CONCLUSION The BSREM reconstruction algorithm showed a relevant improvement compared with OSEM reconstruction in PET/CT studies in all evaluated categories. BSREM might be used in clinical routine in conjunction with TOF to achieve better/higher image quality and lesion detectability or in PET/CT-systems without TOF-capability for enhancement of overall image quality as well. Purpose To investigate the clinical performance of a block sequential regularized expectation maximization (BSREM) penalized likelihood reconstruction algorithm in oncologic PET/computed tomography (CT) studies.Methods A total of 410 reconstructions of 41 fluorine-18 fluorodeoxyglucose-PET/CT studies of 41 patients with a total of 2010 lesions were analyzed by two experienced nuclear medicine physicians. Images were reconstructed with BSREM (with four different β values) or ordered subset expectation maximization (OSEM) algorithm with/without time-of-flight (TOF/non-TOF) corrections. OSEM reconstruction postfiltering was 4.0 mm full-width at halfmaximum; BSREM did not use postfiltering. Evaluation of general image quality was performed with a five-point scale using maximum intensity projections. Artifacts (category 1), image sharpness (category 2), n...

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“…Positron emission tomography (PET) with F-18-fluorodeoxyglucose (F-18-FDG) depicts cellular glucose metabolism with a high uptake being indicative of a high cellular turnover and, hence, consistent with ongoing infection, inflammation, or high grade malignancy (Hess, et al, 2014). Functional imaging with somatostatin analogues are used for visualizing neuroendocrine tumors (NETs) expressing somatostatin receptors due to their resemblance with normal neuroendocrine tissue.…”

Section: Introductionmentioning

confidence: 99%

Somatostatin Receptor Imaging May Establish the Neuroendocrine Nature of Unclarified Metastases

Pedersen¹,

Wilson²,

Simonsen³

2015

JMED

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The Pivotal Role of FDG-PET/CT in Modern Medicine

Cited by 108 publications

References 129 publications

The Empirical Foundations of Teleradiology and Related Applications: A Review of the Evidence

The Empirical Foundations of Teleradiology and Related Applications: A Review of the Evidence

Clinical evaluation of a block sequential regularized expectation maximization reconstruction algorithm in 18F-FDG PET/CT studies

Somatostatin Receptor Imaging May Establish the Neuroendocrine Nature of Unclarified Metastases

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