The Pivotal Neuroinflammatory, Therapeutic and Neuroprotective Role of Alpha-Mangostin

Abstract

Alpha-mangostin (α-MG), one of the key xanthone derivatives, displays a multiplicity of curative qualities like antiinfective, anti-malarial, anticarcinogenic, antidiabetic actions as well as antioxidant properties. Furthermore, it has proven to have neuroprotective, hepatoprotective, and cardioprotective features, of which the anticarcinogenic action is the most auspicious. Additionally, several in vitro and in vivo analyses confirm that α-MG partakes in the major stages of tumor growth: initiation, promotion, and progression. Nevertheless, α-MG services as an inhibitory agent that modulate various enzymes involved in the metabolic activation and excretion of carcinogens, resistance to oxidative damage, and attenuation of inflammatory response. Numerous studies have also implicated α-MG in central nervous system (CNS) disorders, among which neuroinflammatory disorders and brain cancer are cardinal. Based on these initial studies on α-MG, we reviewed the pivotal role of α-MG in neuroinflammatory disorders.

The Therapeutic Potential of Resveratrol in Gliomas

“…Studies have shown that brain tissue is specifically susceptible to oxidative injury. This could perhaps because of its extreme utilization of oxygen resulting in consequential production of excessive amounts of reactive oxygen species (ROS)1 during oxidative phosphorylation (16,33,111). Also, secretion of enzymes like monoamine oxidase and tyrosine hydroxylase in brain results in hydrogen peroxide (H 2 O 2 ) production.…”