“The Pituitary within GRASP” – Golden-Angle Radial Sparse Parallel Dynamic MRI Technique and Applications to the Pituitary Gland

Lee, Matthew; Young, Matthew; Fatterpekar, Girish M.

doi:10.1053/j.sult.2021.04.007

Cited by 3 publications

(12 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4,18 GRASP imaging offers several advantages over conventional DCE-MRI techniques, both generally and specifically for brain tumor imaging. 11 GRASP's continuous radial sampling and reconstruction process provides high isotropic spatial resolution over the entire brain and adjustable temporal resolution, whereas conventional DCE-MRI techniques often limit the field of view or image resolution to accommodate multiple separate acquisitions. Unlike conventional DCE-MRI, GRASP is robust against artifacts from respiratory motion and arterial pulsation while also providing homogeneous fat suppression, which can aid the differentiation of fat, hemorrhage, and surgical packing in the postoperative setting.…”

Section: Discussionmentioning

confidence: 99%

Distinguishing Brain Metastasis Progression From Radiation Effects After Stereotactic Radiosurgery Using Longitudinal GRASP Dynamic Contrast-Enhanced MRI

et al. 2022

Self Cite

View full text Add to dashboard Cite

BACKGROUND:Differentiating brain metastasis progression from radiation effects or radiation necrosis (RN) remains challenging. Golden-angle radial sparse parallel (GRASP) dynamic contrast-enhanced MRI provides high spatial and temporal resolution to analyze tissue enhancement, which may differ between tumor progression (TP) and RN.OBJECTIVE:To investigate the utility of longitudinal GRASP MRI in distinguishing TP from RN after gamma knife stereotactic radiosurgery (SRS).METHODS:We retrospectively evaluated 48 patients with brain metastasis managed with SRS at our institution from 2013 to 2020 who had GRASP MRI before and at least once after SRS. TP (n = 16) was pathologically confirmed. RN (n = 16) was diagnosed on either resected tissue without evidence of tumor or on lesion resolution on follow-up. As a reference, we included a separate group of patients with non–small-cell lung cancer that showed favorable response with tumor control and without RN on subsequent imaging (n = 16). Mean contrast washin and washout slopes normalized to the superior sagittal sinus were compared between groups. Receiver operating characteristic analysis was performed to determine diagnostic performance.RESULTS:After SRS, progression showed a significantly steeper washin slope than RN on all 3 follow-up scans (scan 1: 0.29 ± 0.16 vs 0.18 ± 0.08, P = .021; scan 2: 0.35 ± 0.19 vs 0.18 ± 0.09, P = .004; scan 3: 0.32 ± 0.12 vs 0.17 ± 0.07, P = .002). No significant differences were found in the post-SRS washout slope. Post-SRS washin slope differentiated progression and RN with an area under the curve (AUC) of 0.74, a sensitivity of 75%, and a specificity of 69% on scan 1; an AUC of 0.85, a sensitivity of 92%, and a specificity of 69% on scan 2; and an AUC of 0.87, a sensitivity of 63%, and a specificity of 100% on scan 3.CONCLUSION:Longitudinal GRASP MRI may help to differentiate metastasis progression from RN.

show abstract

Section: Discussionmentioning

confidence: 99%

Distinguishing Brain Metastasis Progression From Radiation Effects After Stereotactic Radiosurgery Using Longitudinal GRASP Dynamic Contrast-Enhanced MRI

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recent studies have proven the importance of this technique via the detection of microadenomas in patients, particularly those with Cushing's disease, with a sensitivity of 67-95% compared with that of 50-60% under conventional contrast-enhanced MRI [30][31][32]. Microadenomas show delayed enhancement and regression, making them more visible on DCE-MRI than conventional sequences, and a few may only appear on dynamic sequences [33]. Dynamic contrast-enhanced magnetic resonance imaging has become routine for initial imaging studies in central endocrine disorders, namely, prolactinomas, due to its negative predictive value and high sensitivity in detecting microadenomas [33].…”

Section: Dynamic Contrast-enhanced Magnetic Resonance Imagingmentioning

confidence: 99%

“…Microadenomas show delayed enhancement and regression, making them more visible on DCE-MRI than conventional sequences, and a few may only appear on dynamic sequences [33]. Dynamic contrast-enhanced magnetic resonance imaging has become routine for initial imaging studies in central endocrine disorders, namely, prolactinomas, due to its negative predictive value and high sensitivity in detecting microadenomas [33]. Additionally, DCE-MRI advances surgical planning by distinguishing between normal tissue and lesions [8,34].…”

Section: Dynamic Contrast-enhanced Magnetic Resonance Imagingmentioning

confidence: 99%

“…In most instances, the lack of temporal resolution hinders quantitative pharmacokinetic analysis. In the postoperative setting, conventional techniques are insufficient in fat saturation, which typically is advantageous in contrasts of hemorrhage, fat, and surgical packing material [33].…”

Section: Dynamic Contrast-enhanced Magnetic Resonance Imagingmentioning

confidence: 99%

“…Golden-angle radial sparse parallel imaging develops all the dynamic data by completion in a single persistent scan. First, the data is separated into sequential time frames and then recreated via an iterative method, which connects compressed sensing and parallel imaging [33,36,37].…”

Section: Golden-angle Radial Sparse Parallel Imagingmentioning

confidence: 99%

See 2 more Smart Citations

New Progress in Imaging of Pituitary Diseases

Wu¹

2024

Frontiers in Neuroimaging

View full text Add to dashboard Cite

In the last 20 years, there have been advances in imaging techniques for pituitary diseases. Magnetic resonance imaging (MRI) particularly presents high-quality structural images and the essential information needed to authorize surgery, radiation therapy, and/or drug therapy. These images can assist in monitoring long-term outcomes. Recent technological advances, such as the advent of 7-Tesla MRI, have been used for measuring tumor consistency in pituitary adenomas. Microadenomas and other pituitary incidentaloma have been more recognized in the presence of golden-angle radial sparse parallel imaging and conventional dynamic contrast-enhanced techniques. However, standard structural (anatomical) imaging, mainly in the form of MRI, acts inadequately to identify all tumors, especially microadenomas (< 1 cm diameter), recurrent adenomas, and several incidentalomas. In this respect, nuclear isotope (radionuclide) imaging promotes tumor detection beneficially. All these imaging improvements may play a central role in clinical practice, especially when considering diagnosis, differential diagnosis, or definitive intervention. They further form accurate diagnosis, advise surgery, and decrease the risk of disrupting normal pituitary function.

show abstract

Emerging diagnostic methods and imaging modalities in cushing’s syndrome

Wright¹,

Rossum²,

Zan³

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

Endogenous Cushing’s syndrome (CS) is a rare disease characterized by prolonged glucocorticoid excess. Timely diagnosis is critical to allow prompt treatment and limit long-term disease morbidity and risk for mortality. Traditional biochemical diagnostic modalities each have limitations and sensitivities and specificities that vary significantly with diagnostic cutoff values. Biochemical evaluation is particularly complex in patients whose hypercortisolemia fluctuates daily, often requiring repetition of tests to confirm or exclude disease, and when delineating CS from physiologic, nonneoplastic states of hypercortisolism. Lastly, traditional pituitary MRI may be negative in up to 60% of patients with adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas (termed “Cushing’s disease” [CD]) whereas false positive pituitary MRI findings may exist in patients with ectopic ACTH secretion. Thus, differentiating CD from ectopic ACTH secretion may necessitate dynamic testing or even invasive procedures such as bilateral inferior petrosal sinus sampling. Newer methods may relieve some of the diagnostic uncertainty in CS, providing a more definitive diagnosis prior to subjecting patients to additional imaging or invasive procedures. For example, a novel method of cortisol measurement in patients with CS is scalp hair analysis, a non-invasive method yielding cortisol and cortisone values representing long-term glucocorticoid exposure of the past months. Hair cortisol and cortisone have both shown to differentiate between CS patients and controls with a high sensitivity and specificity. Moreover, advances in imaging techniques may enhance detection of ACTH-secreting pituitary adenomas. While conventional pituitary MRI may fail to identify microadenomas in patients with CD, high-resolution 3T-MRI with 3D-spoiled gradient-echo sequence has thinner sections and superior soft-tissue contrast that can detect adenomas as small as 2 mm. Similarly, functional imaging may improve the identification of ACTH-secreting adenomas noninvasively; Gallium-68-tagged corticotropin-releasing hormone (CRH) combined with PET-CT can be used to detect CRH receptors, which are upregulated on corticotroph adenomas. This technique can delineate functionality of adenomas in patients with CD from patients with ectopic ACTH secretion and false positive pituitary lesions on MRI. Here, we review emerging methods and imaging modalities for the diagnosis of CS, discussing their diagnostic accuracy, strengths and limitations, and applicability to clinical practice.

show abstract

“The Pituitary within GRASP” – Golden-Angle Radial Sparse Parallel Dynamic MRI Technique and Applications to the Pituitary Gland

Cited by 3 publications

References 27 publications

Distinguishing Brain Metastasis Progression From Radiation Effects After Stereotactic Radiosurgery Using Longitudinal GRASP Dynamic Contrast-Enhanced MRI

Distinguishing Brain Metastasis Progression From Radiation Effects After Stereotactic Radiosurgery Using Longitudinal GRASP Dynamic Contrast-Enhanced MRI

New Progress in Imaging of Pituitary Diseases

Emerging diagnostic methods and imaging modalities in cushing’s syndrome

Contact Info

Product

Resources

About