The pituitary-adrenocortical system and anxiety in avoidance learning

Applezweig, Mortimer H.; Moeller, George

doi:10.1016/s0001-6918(59)80331-0

Cited by 38 publications

(7 citation statements)

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“…The hypophysectomized animals were capable of the learning required, but their reaction to the CS was significantly slower than that of the controls. These findings agree with those of other workers (1,2).…”

Section: Discussionsupporting

confidence: 94%

Effets de l'hypophysectomie sur l'apprentissage d'une réction échappement-évitement.

Bélanger¹

1958

Canadian Journal of Psychology / Revue canadienne de psychologi

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Section: Discussionsupporting

confidence: 94%

Effets de l'hypophysectomie sur l'apprentissage d'une réction échappement-évitement.

Bélanger¹

1958

Canadian Journal of Psychology / Revue canadienne de psychologi

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“…The performance of septal rats in this study was consistent with previous findings [cf. 9], Also, the finding that adrenalectomies did not cause avoidance behavior different from con trols agreed with a number of earlier studies [1,14,15,20], In general, rats in group SEP-ADX showed similar behavioral patterns in the acquisition and extinction of an avoidance response as rats in group SEP. One difference between these groups was the number of inter trial crossings during the habituation and ex tinction conditions. In these conditions the behavior of groups SEP and CON were more similar than the behavior of animals in groups SEP and SEP-ADX.…”

Section: Discussionsupporting

confidence: 87%

Effects of Septal Lesions and Adrenalectomies on the Acquisition and Extinction of Shuttle Avoidance in the Rat

Poplawsky¹,

Bucher²

1979

Neuroendocrinology

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Rats with septal lesions and rats with both septal lesions and adrenalectomies (SEP-ADX) acquired avoidance behaviors faster and extinguished these behaviors slower than rats with adrenalectomies or control lesions. Rats with septal lesions also showed increased intertrial crossings during habituation, acquisition, and extinction while rats in group SEP-ADX only had increased intertrial crossings during acquisition. These findings are consistent with the hypothesis that the avoidance performance of rats with septal lesions is a result of neural rather than hormonal factors.

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“…EFFeCtS of ACTH or corticosteroids on either active [1,2,3,7,12,16,17] or passive [14, 15] avoidance behavior have been described during the past decade. Removal of the posterior pituitary facilitates extinction of an avoidance response while the administration of ACTH, ~-MSH or [3-MSH during the extinction period maintains avoidance behavior of the posterior lobectomized rat [8].…”

Section: A-msh Extinction Of Conditioned Avoidance Response Parafascimentioning

confidence: 99%

Failure of α-MSH to delay extinction of conditioned avoidance behavior in rats with lesions in the parafascicular nuclei of the thalamus

Bohus¹,

Wied²

1967

Physiology & Behavior

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BOHUS, B. AND D. DE WILD. Failure of a-MSH to delay extinction of conditioned avoidance behavior in rats with lesions in the parafascicular nuclei of the thalamus. PHYSIOL. BEHAV. 2(2) [221][222][223] 1967. Bilateral lesions in the thala,alic parafascicular area facilitate the rate of extinction of a conditioned avoidance response without affecting avoidance learning. Treatment with long-acting a-MSH during extinction failed to affect the rate of extinction of the avoidance response. Since this peptide delays extinction of the avoidance response in posterior lobectomized rats in which a similar rapid rate of extinction is found as in rats with lesions in the parafascicular nuclei (De Wied, 1965), the results stress the importance of the central nervous system tor the effect of a-MSH on conditioned avoidance behavior. a-MSH Extinction of conditioned avoidance response Parafascicular nuclei LesionsEFFeCtS of ACTH or corticosteroids on either active [1,2,3,7,12,16,17] or passive [14, 15] avoidance behavior have been described during the past decade. Removal of the posterior pituitary facilitates extinction of an avoidance response while the administration of ACTH, ~-MSH or [3-MSH during the extinction period maintains avoidance behavior of the posterior lobectomized rat [8]. Rats with lesions in the parafascicular nuclei of the thalamus like posterior lobectomized rats rapidly extinguish a conditioned avoidance response. Since a-MSH had been shown to delay the rate of extinction of the avoidance response in posterior lobectomized rats [8], the effect of ~-MSH treatment was studied on extinction of a similar conditioned avoidance response in rats bearing bilateral lesions in the parafascicular region of the thalamus in an attempt to localize the "site" of action of ACTH-Iike peptides on conditioned avoidance behavior. METHODSA total of fifty male albino rats of an inbred strain were used. The rats weighed 120-130 g at the time of operation.Destruction of the parafascicular region of the thalamus was performed under ether anesthesia by high frequency electrocauter/zation with the following parameters: 40 mA d.c. for 4 msec [5]. Bilateral lesions were made using a stainless steel electrode which was inserted stereotaxically into the appropriate thalamic areas. Control rats were sham-operated by inserting the electrode without applying the current.The rats were allowed to recover for two weeks before conditioning was begun. Avoidance conditioning was performed in a shuttle-box described by Murphy and Miller [17]. The box was divided into two equal compartments by a 2 in. barrier. Each compartment had a grid floor through which the unconditioned stimulus (US) of shock (25 V; 1.8 mA) was delivered to the feet of rats. The sound of a buzzer served as the conditioned stimulus (CS). The CS was presented 5 sec prior to the US. If the animal crossed the barrier within 5 sec, the CS was immediately terminated and the rat avoided shock.Rats were placed into the shuttle-box 1 min prior to the first trial. Ten conditioning trials...

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The pituitary-adrenocortical system and anxiety in avoidance learning

Cited by 38 publications

References 0 publications

Effets de l'hypophysectomie sur l'apprentissage d'une réction échappement-évitement.

Effets de l'hypophysectomie sur l'apprentissage d'une réction échappement-évitement.

Effects of Septal Lesions and Adrenalectomies on the Acquisition and Extinction of Shuttle Avoidance in the Rat

Failure of α-MSH to delay extinction of conditioned avoidance behavior in rats with lesions in the parafascicular nuclei of the thalamus

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