The piperazine scaffold for novel drug discovery efforts: the evidence to date

Amphiphilic Polyurethane with Cluster-Induced Emission for Multichannel Bioimaging in Living Cell Systems

“…This work should further inspire the exploitation of aggregation-induced luminescence based on restricted intramolecular motions of single-component polyurethane derivatives for biomedical and other emerging applications . The piperazine skeleton plays an important role in the development of new biological targets for the treatment of various diseases . However, there are fewer reports on pyrazine fragments in the field of medicinal chemistry. , This study can promote the application of pyrazine derivatives in rational drug design and nanomedicinal chemistry research.…”

“…48 The piperazine skeleton plays an important role in the development of new biological targets for the treatment of various diseases. 49 However, there are fewer reports on pyrazine fragments in the field of medicinal chemistry. 50,51…”

Cannabidiol-Based Prodrugs: Synthesis and Bioevaluation

“…Here, we have synthesized the CBD-based prodrugs utilizing various heterocyclic moieties such as morpholinoacetyl, piperidinyl, piperazinyl, and pyrrolidinyl with an ester linkage. The synthesized conjugates possess cyclic heterocyclic moieties with the purpose of enhancing the solubility and bioavalability , which eventually will be helpful for designing of suitable oral delivery systems. Moreover, the chosen heterocyclic moieties are also present in various therapeutic agents and known for their safety. − The general synthetic scheme adopted for the CBD–prodrug conjugates is shown in Scheme .…”

Photocatalysis and Kinetic Resolution by Lithiation to Give Enantioenriched 2-Arylpiperazines

“…Piperazines are one of the most important saturated nitrogen heterocycles found in small-molecule pharmaceuticals . Their druglike properties and synthetic versatility make them excellent candidates in drug discovery programs.…”

“…Piperazines are one of the most important saturated nitrogen heterocycles found in small-molecule pharmaceuticals. 1 Their druglike properties and synthetic versatility make them excellent candidates in drug discovery programs. For example, imatinib (marketed as Gleevec), a BCR-Abl tyrosine kinase inhibitor, is used in the treatment of multiple cancers with high response rate, 2 and gatifloxacin is an important fluoroquinolone antibiotic ( Figure 1 ).…”