The pioneer use of a modified PRGF–Endoret® technique for wound healing in a hemodialyzed diabetic patient in a terminal stage of renal disease

Abstract

In the literature, this paper is the first to describe the use of plasma rich in growth factors (PRGF)-Endoret ® in hemodialyzed diabetic patients, to promote the healing of after amputation wounds. The PRGF-Endoret ® was primarily conceived to be used in maxillofacial surgery, oral implantology, etc., the innovation residing in the blood collection technique (quantity, moment of the week, rhythmicity), which was adapted to the specific conditions of the hemodialyzed patient. Moreover, in the initial phases, the two PRGF fractions were innovatively applied as single alternating layers on the wound surface. Only after the surface of the wound decreased, the two PRGF fractions were applied as overlapping layers. Nevertheless, the paper presents the optimal method to assess the clinical evolution of the wound. Histopathological examination of the biopsy performed during wound preparation for PRGF application brought additional, essential data for orienting the therapeutic approach. The exclusion of calciphylaxis, a disease with high mortality risk, encouraged the application of this method, and also demonstrated the microscopic features in hemodialyzed diabetic patients.

Antimicrobial Treatment Challenges in the Management of Infective Spondylodiscitis Associated with Hemodialysis: A Comprehensive Review of Literature and Case Series Analysis

“…In the literature, neurosurgical interventions are frequent [ 38 , 39 ]. Reconstructive strategies could be performed, and the use of PRGF in this context should be an option for HD patients [ 73 ]. The localization of the infectious process was predominantly lumbar in HD patients (61.63%); the data in the literature concerning this matter are divergent [ 17 , 39 ].…”

Treatment of skin defects with PRP enriched with hyaluronic acid – histological aspects in rat model

“…PRP is a source of growth factors and, consequently, has mitotic, angiogenic, and chemotactic properties, representing an adjuvant treatment alternative for acute and chronic wounds. Furthermore, the application of PRP has been shown to be effective not only in the repair of soft tissues [ 24 , 25 ], but also in bone and cartilage reconstruction, tendons [ 26 , 27 , 28 , 29 ], hair growth, etc. The addition of bioactive excipients, such as HA, appears to accelerate endothelial, epithelial, and epidermal regeneration of PRP [ 30 , 31 ].…”