The Pineal Gland and Chronobiologic History: Mind and Spirit as Feedsidewards in Time Structures for Prehabilitation

Halberg, Franz; Cornélissen, Germaine; Conti, Ario; Maestroni, Georges J. M.; Maggioni, C.; Perfetto, Federico; Salti, R; Tarquini, Roberto; Katinas, George; Schwartzkopff, Othild

doi:10.1007/978-3-642-59512-7_4

Cited by 14 publications

(17 citation statements)

References 45 publications

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“…This conclusion would not have been possible without a time-microscopic inferential statistical analysis. Phase differences between melatonin released from the pineal and other sources, such as hypothalamus and anterior pituitary, have already been described in other studies [10,31], but the corroborated lead in phase of melatonin in the gut is the main point of this paper, awaiting scrutiny as to its degree of generality.…”

Section: Discussionsupporting

confidence: 57%

“…[8][9][10]) is here applied to melatonin, usually regarded as the hormone of the pineal gland, but also synthesized by various extrapineal tissues [12,15,23,25,26]. Among those, the digestive tract represents a system which contains by far the highest amount of this indoleamine [4][5][6]15,23].…”

Section: Introductionmentioning

confidence: 99%

“…Since the amounts of total gastrointestinal melatonin are up to orders of magnitude higher than those found in the pineal [4][5][6]12,15], the contribution of this extrapineal source to the levels of circulating melatonin is of conside-rable interest. This question cannot be definitely solved by pinealectomy, since any persisting rhythms may be attributed to other extrapineal sources, such as the retina, bone marrow, pituitary and hypothalamus [10,31] oras assumed in the pigeon [29]-the Harderian gland.…”

Section: Introductionmentioning

confidence: 99%

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Chronomics affirm extending scope of lead in phase of duodenal vs. pineal circadian melatonin rhythms

Pöeggeler

Cornélissen

Huether

et al. 2005

Biomedicine & Pharmacotherapy

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In Göttingen, Germany, circadian variations in melatonin had been determined time-macroscopically in pineal glands, blood plasma and duodenum of chicken and rats. When these data were metaanalyzed, they agreed with the results from an independent survey on tissues from rats collected in a laboratory in Pécs, Hungary. In the latter study, tissues were analyzed chemically in Bratislava, Slovakia, and numerically in Minneapolis, MN, USA, all by single-and multiple-component cosinor and parameter tests. In rats and chickens, these inferential statistical procedures clearly demonstrated a lead in phase of the 24-h cosine curves best fitting all of the duodenal vs. those best fitting all of the pineal melatonin values in each species in 2 geographic (geomagnetic) locations. The 24-h cosine curve of circulating melatonin was found to be in an intermediate phase position. Mechanisms of the phase differences and the contribution of gastrointestinal melatonin to circulating hormone concentrations are discussed.

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Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chronomics affirm extending scope of lead in phase of duodenal vs. pineal circadian melatonin rhythms

Pöeggeler

Cornélissen

Huether

et al. 2005

Biomedicine & Pharmacotherapy

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Section: Introductionmentioning

confidence: 99%

“…Melatonin is found to peak during the daily dark span, with but few exceptions in humans [6] and other organisms [7][8][9], when time-microscopy is used. The variation is obvious to the naked eye and quantifiable with its parameters by time-microscopy [7]. Chronomics, the study of chronomes (time structures) in data of the stroke-prone spontaneously hypertensive Okamoto rat, has revealed phase differences among circadian melatonin rhythms in the hypothalamus and the pituitary vs. that in the pineal [8].…”

Section: Introductionmentioning

confidence: 99%

Chronomics reveal and quantify circadian rhythmic melatonin in duodenum of rats

Stebelová

Zeman

Cornélissen

et al. 2005

Biomedicine & Pharmacotherapy

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A circadian rhythm is documented in duodenal melatonin in rats, peaking 16.8 hours after light onset. This component is more readily detected after logl0-transformation of the data. It differs between male and female rats, females having a larger circadian amplitude and an earlier acrophase. The circadian rhythm in duodenal melatonin is also found to lead that of pineal melatonin. The results are qualified by the presence at the start of mapping of the second extremum of a double magnetic storm. KeywordsChronomics; Duodenum; Rats; Circadian; Melatonin AimTo examine in rats, as a widely used model, whether the mammalian gut is characterized by a variation for which the zero circadian amplitude assumption can be rejected. If by this objective time-microscopic cosinor approach, a rhythm can be validated, we can also examine the timing of a duodenal rhythm in the light of circadian acrophases in other tissues obtained concomitantly. Data from the same rats on other tissues were also analyzed to assess their time structure by chronomics, in international cooperative studies along the scale of the day and the week.*Corresponding author. E-mail address: halbe00l @ umn.edu (F. Halberg). NIH Public Access BackgroundAs a rule, in health [1][2][3][4][5] in many species, a prominent time-macroscopic human, murine and avian circadian melatonin rhythm characterizes not only the circulation but also the pineal. Melatonin is found to peak during the daily dark span, with but few exceptions in humans [6] and other organisms [7][8][9], when time-microscopy is used. The variation is obvious to the naked eye and quantifiable with its parameters by time-microscopy [7]. Chronomics, the study of chronomes (time structures) in data of the stroke-prone spontaneously hypertensive Okamoto rat, has revealed phase differences among circadian melatonin rhythms in the hypothalamus and the pituitary vs. that in the pineal [8]. This study was designed to explore any circadian variation of melatonin in the duodenum, in the context of that in other different tissues of the same group of rats, sampled around the clock for 7 days, even though each rat could only be sampled once. Duodenal tissue was only available from a fraction of the animals used for measurement of melatonin in plasma, pineal gland and hypothalamus [9]. An additional meta-analysis on data from Bratislava on the quail [10] is beyond our scope herein, even if, as originally stated, it represents an important qualification of any generalization. Materials and methodsOne hundred and three Wistar (Amsterdam) rats (52 males and 51 females) had been randomly assigned to two rooms kept for a standardization span of 1 month on opposite LD12:12 regimens, to be sampled for 7 days only during working hours at 4-h intervals at six circadian stages should the adjustment to the antiphase regimen be complete. This adjustment was validated by the agreement of data on plasma and pineal with those reported earlier. After bleeding, the animals were killed by cervical dislocation; the tissue...

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Implications and Applications of Circadian Susceptibility Rhythms: Chronomics and Anesthesia

Halberg

Cornélissen

Schwartzkopff

2009

Chronopharmaceutics

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The Pineal Gland and Chronobiologic History: Mind and Spirit as Feedsidewards in Time Structures for Prehabilitation

Cited by 14 publications

References 45 publications

Chronomics affirm extending scope of lead in phase of duodenal vs. pineal circadian melatonin rhythms

Chronomics affirm extending scope of lead in phase of duodenal vs. pineal circadian melatonin rhythms

Chronomics reveal and quantify circadian rhythmic melatonin in duodenum of rats

Implications and Applications of Circadian Susceptibility Rhythms: Chronomics and Anesthesia

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