The phytochemical investigation of five African Croton species: Croton oligandrus, Croton megalocarpus, Croton menyharthii, Croton rivularis and Croton megalobotrys

Langat, Moses K.; Djuidje, Elvire F.K.; Ndunda, Beth; Isyaka, Sani M.; Dolan, Nathalie S.; Ettridge, Gareth D.; Whitmore, Hannah; Lopez, Isabel; Alqahtani, Alaa M.; Atiku, I.; Lobe, Jules Songue; Mas‐Claret, Eduard; Crouch, Neil R.; Midiwo, Jacob O.; Mulholland, Dulcie A.; Kamdem, Alain François Waffo

doi:10.1016/j.phytol.2020.09.020

Cited by 17 publications

(16 citation statements)

References 34 publications

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“…A number of pharmacological studies confirmed the antileishmanial activities C. macrostachyus [51] due to its phytochemical constituencies. Phytochemical studies indicated that the Croton plants are endowed with many classes of secondary metabolites mainly alkaloids, flavonoids, terpenoids and essential oils such as mono and sesquiterpenoids [52,53].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Antileishmanial Activities of Olea europaea, Kigelia africana, Terminalia mollis, Croton Macrostachyus and Bridella micrantha, Kenyan Medicinal Plants

Wafula

Ayieko

Collins

et al. 2020

IJTDH

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Leishmaniasis is a major public health problem globally. Visceral leishmaniasis is known to be fatal if left untreated, while cutaneous leishmaniasis is the most neglected. The first-line treatment of leishmaniasis is based on pentavalent antimonial drugs which are expensive, requiring inpatient treatment and toxic. The Plants containing active compounds against other protozoan diseases may offer alternatives against leishmania parasites. This study determined the in vitro antileishmanial activity of Olea europaea, Kigelia africana, Terminalia mollis, Croton macrostachyus and Bridella micrantha extracts. The plant samples were dried, pulverized into fine powders and extracted using ethanol at the Center for Traditional Medicine and Drugs Research, KEMRI. The in vitro assays were carried out at the Leishmania laboratory, Centre for Biotechnology Research and Development, KEMRI. In in- vitro assays the inhibitory concentrations (IC50) and Minimum Inhibition Concentration (MIC) on L. major promastigotes, percentage rates of macrophages infected by amastigotes and cytotoxicity on Vero cells were determined. For each parameter analyzed, differences among treatment groups exposed to different drugs were tested by logistic regression. Results showed that promastogote and amastigote growth inhibition was significantly affected by the crude extracts from the plants (P < 0.05) after 24 hours of exposure where the most effective drug was the standard drug (Amphotericin B) while among the crude extracts of the herbal drugs, T. mollis was the most effective against amastigote followed by C. macrostachyus while O. europaea was the least effective. Mammalian cell viability was significantly affected by the various test compounds (P < 0.05) after 24 hours exposure where % cell viability of herbal drugs, B. microstachyus, O. africana resulted to the most toxic effects by reducing the % cell viability to less than 50%. The study recommends the use of T. mollis in management of leishmaniasis in areas they occur. Further analysis of the active compounds that that affect efficacy of the plant extracts is advised.

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Section: Discussionmentioning

confidence: 99%

In Vitro Antileishmanial Activities of Olea europaea, Kigelia africana, Terminalia mollis, Croton Macrostachyus and Bridella micrantha, Kenyan Medicinal Plants

Wafula

Ayieko

Collins

et al. 2020

IJTDH

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“…Influenza, colds, fevers, and rheumatism were managed using smoked dried leaves and leaves in steam bath [ 23 , 25 ]. In Zimbabwe and Botswana, the Shona community used leaf decoction with tea or leave smokes as cough suppressant [ 25 , 26 ]. The leaf decoctions in Benin have been used as antihypertensive and antimicrobial (managing urinary tracts infections) agents [ 27 , 28 ].…”

Section: Phytomedicinementioning

confidence: 99%

Phylogeny, Phytomedicines, Phytochemistry, Pharmacological Properties, and Toxicity of Croton gratissimus Burch (Euphorbiaceae)

Magwilu

Nguta

Mapenay

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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Croton gratissimus is an important plant in Africa setup and across the globe for its ethnomedicinal uses in managing a wide range of diseases. Its phylogeny, pharmacological properties, ethnomedicinal uses, phytochemistry, and cytotoxicity have been highlighted in various articles and journals. This review article aims to give a comprehensively overviewed literature about Croton gratissimus genus. Authentic literature sources such as books, peer reviewed articles, journals, theses, Google Scholar, Science Direct, and any other validated internet source have been used to develop this review. Croton gratissimus is richly found across different climatic zones because of its ability to adapt to various climatic conditions. It is mainly found in rocky hills as a scrub that is about 12–15 m tall. Its leaves are glossy, green on the top, and silvery underneath. Some of the leaves may look brick red rusty. Croton gratissimus has been explored traditionally to manage a number of diseases among the human race since time immemorial. It has been used to treat different ailments ranging from respiratory tract infections, urinary tract infections, malaria, diabetes, hypertension, dermatological conditions, arthritis, gastrointestinal disorders, fever, sexually transmitted diseases, and infertility. Studies have shown that parts of this plant have antioxidative, antimicrobial, anticholinesterases inhibitory, antidiabetic, antihyperlipidemic, anticonvulsant, antiulcer, antihypertensive, antiproliferative, antiplasmodial, and anti-inflammatory activities. Terpenoids and flavonoids have shown to be the major classes of compounds in this plant. Its toxicity has not been well established; some studies have suggested that Croton gratissimus can cause hepatotoxicity and genotoxicity. More studies are needed to elucidate the compounds and their structures giving this plant a wide range of pharmacological activities, efficacy, safety, and toxicity levels, since the plant has greater ethnomedicinal uses. This would give a great indication of discovering new novelties that can give a breakthrough in drug discovery.

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“…C. megalobotrys is a medium-sized tree growing up to 15 m high and is known as the Fever berry tree in English (Langat et al, 2020). In Botswana, the tree is found in the Northwestern part of the country mainly along the large rivers in that area such as the Thamalakane River, Okavango River, and the pristine Okavango Delta.…”

Section: Traditional Uses Of C Megalobotrysmentioning

confidence: 99%

Evaluation of two Non-Edible, Wild Indigenous Botswana Crops (Croton megalobotrys (Motsebi/Letsebi/Moshoole) and Ricinus communis (Mokhure)) as Potential Feedstocks for Petroleum and Cosmetic Industries

Paphane

Nkoane

Oyetunji

2021

East Afr. j. environ. nat. resour.

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Croton megalobotrys and Ricinus cummunis plants produce high-quality non-edible seed oils at relatively high quantities of 39.65 ± 0.06 % w/w to 53.74 ± 0.04 % w/w. The Iodine values of 85.97 ± 1.62 g I2/100 g to 96.51 ± 1.31 g I2/100 g; the low acid values of 0.96 ± 0.05 mg KOH/g to 5.31 ± 0.76 mg KOH/g; and high saponification values of 139.65 ± 1.06 mg KOH/g to 153.01 ± 1.67 mg KOH/g show that these seed oils can be useful feedstocks in the petroleum, soap, and cosmetics industries. GC-MS results revealed that R. cummunis seed oil is made up of eight (8) fatty acids with the bulk being ricinoleic acid at 81.51 %. Ricinoleic acid is the main fatty acid used in oleochemical industries. C. megalobotrys seed oil is made up of five (5) fatty acids, the most abundant being Linoleic acid which makes up 58.01 % of the seed oil. The other two significant fatty acids in C. megalobotrys seed oil are palmitic and oleic acids at 19.51 % and 18.37 %, respectively. These acids are important as starting materials in soap, cosmetic, and pharmaceutical industries. The fatty acids of the two seed oils absorb light at the ultraviolet region of the electromagnetic spectrum. This means that cosmetic products made from these seed oils will be effective in protecting the human skin against ultraviolet radiation. The FT-IR peaks for the two seed oils show that even though these seed oils are made up of different fatty acids, the active sites of their fatty acids are similar, implying that these seed oils can be used as starting materials in similar industries.

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The phytochemical investigation of five African Croton species: Croton oligandrus, Croton megalocarpus, Croton menyharthii, Croton rivularis and Croton megalobotrys

Cited by 17 publications

References 34 publications

In Vitro Antileishmanial Activities of Olea europaea, Kigelia africana, Terminalia mollis, Croton Macrostachyus and Bridella micrantha, Kenyan Medicinal Plants

In Vitro Antileishmanial Activities of Olea europaea, Kigelia africana, Terminalia mollis, Croton Macrostachyus and Bridella micrantha, Kenyan Medicinal Plants

Phylogeny, Phytomedicines, Phytochemistry, Pharmacological Properties, and Toxicity of Croton gratissimus Burch (Euphorbiaceae)

Evaluation of two Non-Edible, Wild Indigenous Botswana Crops (Croton megalobotrys (Motsebi/Letsebi/Moshoole) and Ricinus communis (Mokhure)) as Potential Feedstocks for Petroleum and Cosmetic Industries

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