The phytochemical and anti‐inflammatory studies of <scp><i>Dillenia suffruticosa</i></scp> leaves

Abubakar, Saifullah; Al-Mansoub, Majed Ahmed; Murugaiyah, Vikneswaran; Chan, Kit‐Lam

doi:10.1002/ptr.6255

Cited by 14 publications

(15 citation statements)

References 61 publications

(80 reference statements)

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“…In macrophages, vitexin and isovitexin suppressed COX-1 and COX-2 mRNAs expression [ 103 , 115 – 117 ]. A recent study illustrated that vitexin displayed moderate inhibition more towards COX-2 compared to COX-1 enzyme, and the flavonoids interacted with hydrogen bonding more at the cyclooxygenase catalytic sites just like celecoxib, the known inhibitor [ 118 ]. An in silico study disclosed that vitexin had the highest fitness score against the COX-2 (63.49) and for enzyme COX-1 (60.43) and showed tactical hydrogen bonding against COX-1 and COX-2 [ 119 ].…”

Section: Resultsmentioning

confidence: 99%

Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

Abdulai

Kwofie

Gbewonyo

et al. 2021

The Scientific World Journal

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Background. Till date, there is no known antidote to cure diabetes mellitus despite the discovery and development of diverse pharmacotherapeutic agents many years ago. Technological advancement in natural product chemistry has led to the isolation of analogs of vitexin and isovitexin found in diverse bioresources. These compounds have been extensively studied to explore their pharmacological relevance in diabetes mellitus. Aim of the Study. The present review was to compile results from in vitro and in vivo studies performed with vitexin and isovitexin derivatives relating to diabetes mellitus and its complications. A systematic online literature query was executed to collect all relevant articles published up to March 2020. Results. In this piece, we have collected data and presented it in a one-stop document to support the multitargeted mechanistic actions of vitexin and isovitexin in controlling diabetes mellitus and its complications. Conclusion. Data collected hint that vitexin and isovitexin work by targeting diverse pathophysiological and metabolic pathways and molecular drug points involved in the clinical manifestations of diabetes mellitus. This is expected to provide a deeper understanding of its actions and also serve as a catapult for clinical trials and application research.

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Section: Resultsmentioning

confidence: 99%

Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

Abdulai

Kwofie

Gbewonyo

et al. 2021

The Scientific World Journal

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“…Molecular modeling suggested that KA can form stable complexes with these two proteins (Abubakar et al, 2019;Aswathy et al, 2021).…”

Section: Antic An Cer Comp Oundsmentioning

confidence: 99%

“…The exact molecular targets of KA have not been unambiguously identified. Two protein targets have been proposed based on molecular docking analyses: the enzyme COX‐2 (Abubakar et al, 2019) and protein mTOR (mammalian target of rapamycin) which is included in the mTORC1 complex and implicated in many signaling pathways (Figure 4). Molecular modeling suggested that KA can form stable complexes with these two proteins (Abubakar et al, 2019; Aswathy et al, 2021).…”

Section: Anticancer Compoundsmentioning

confidence: 99%

“…The triterpenoid KA (1), found in S. koetjape and in other plants such as Dillenia suffruticosa and D. serrata (Dilleniaceae) has revealed anti‐inflammatory effects when administered orally (50 mg/kg) in a rat model of λ‐carrageenan‐induced paw edema. The compound exhibited cyclooxygenase inhibitory activities in vitro, moderately reducing the COX‐1 and COX‐2 and possibly binding to the active site of COX‐2 enzyme according to a molecular modeling analysis (Abubakar et al, 2019). But KA exerts multiple effects on enzymes implicated in the inflammation process, notably inhibiting more efficiently the production of prostaglandin E2 (PGE2) than betulinic acid (IC 50 = 1.05 and 2.59 μM for KA and betulinic acid, respectively) in a lipopolysaccharide‐induced human blood assay (Jalil et al, 2015).…”

Section: Anti‐inflammatory Agentsmentioning

confidence: 99%

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The health benefits of santol fruits and bioactive products isolated from Sandoricum koetjape Merr.: A scoping review

Bailly¹

2022

Journal of Food Biochemistry

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The santol tree (Sandoricum koetjape Merr.) is largely distributed in Southeast Asia. It produces useful timber and edible fruits, consumed fresh, and transformed. It has a wide range of traditional medicinal uses for the treatment of inflammatory disorders and digestive troubles. Numerous bioactive natural products have been isolated from the roots, leaves, stems, and fruits of S. koetjape, including flavonoids, limonoids, and terpenoids. The seeds are considered toxic and contain insecticidal limonoids. The present review provides a survey of the natural products isolated from different parts of the plant and discusses their pharmacological properties. Information on S. koetjape was collected through databases and analyzed, leading to the identification of about 30 natural products of interest. Bioactive compounds include limonoids, such as sandoripins A-B, sanjecumins A-B, and sandrapins A-E, and flavonoids with antioxidant, antibacterial, and insecticidal properties such as sandoricin and sandoripin derivatives. The santol plant contains various anti-inflammatory triterpenes, such as sentulic acid and koetjapic acid (KA). KA is the main product found in santol and a few other plants. This tetracyclic triterpenoid is endowed with anti-inflammatory and anticancer properties, with marked antimetastatic and antiangiogenic effects. Its potential molecular targets are discussed, notably the kinase mammalian target of rapamycin (mTOR) and other proteins (cyclooxygenase 2, DNA polymeraseβ). The water-soluble derivative potassium koetjapate (KK) affords an orally bioavailable derivative, with superior antiangiogenic properties compared to KA. The health benefits associated with the consumption of santol fruits shall be further considered, and the design of hemi-synthetic analogs of KA encouraged. Practical applicationsThe fruits of the santol tree are largely consumed in Asia and different parts of the plant (Sandoricum koetjape Merr.) are used in traditional medicine. Diverse bioactive terpenoids have been isolated from the plant. Their pharmacological properties are reviewed here, with a focus on the triterpene koetjapic acid which displays marked anti-inflammatory and anticancer properties. Several other bioactive natural products, including limonoids and flavonoids, are evoked as well, to shed light on the many active compounds found in the fruits and the whole plant. For a healthy life, How to cite this article: Bailly, C. ( 2022). The health benefits of santol fruits and bioactive products isolated from

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“…Gastrointestinal side effects and cardiovascular thrombotic risk of celecoxib and other COX-2-selective drugs have also been reported [ 11 , 12 ]; thus, the use of celecoxib in patients with cardiovascular problems should be avoided [ 13 ]. As an alternative to coxibs, medicinal plants exhibit potent anti-inflammatory properties [ 14 ] due to a variety of their phytochemicals including phenolics [ 14 , 15 , 16 , 17 ], terpeniods [ 18 , 19 ], alkaloids [ 20 ] and flavonoids [ 17 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Computational Analysis and Biological Activities of Oxyresveratrol Analogues, the Putative Cyclooxygenase-2 Inhibitors

et al. 2022

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Polyphenols are a large family of naturally occurring phytochemicals. Herein, oxyresveratrol was isolated from ethanolic crude extracts of Artocarpus lacucha Buch.-Ham., and chemically modified to derive its lipophilic analogues. Biological screening assays showed their inhibitory potency against cyclooxygenase-2 (COX-2) with very low cytotoxicity to the MRC-5 normal cell lines. At the catalytic site of COX-2, docking protocols with ChemPLP, GoldScore and AutoDock scoring functions were carried out to reveal hydrogen bonding interactions with key polar contacts and hydrophobic pi-interactions. For more accurate binding energetics, COX-2/ligand complexes at the binding region were computed in vacuo and implicit aqueous solvation using M06-2X density functional with 6-31G+(d,p) basis set. Our computational results confirmed that dihydrooxyresveratrol (4) is the putative inhibitor of human COX-2 with the highest inhibitory activity (IC50 of 11.50 ± 1.54 µM) among studied non-fluorinated analogues for further lead optimization. Selective substitution of fluorine provides a stronger binding affinity; however, lowering the cytotoxicity of a fluorinated analogue to a normal cell is challenging. The consensus among biological activities, ChemPLP docking score and the binding energies computed at the quantum mechanical level is obviously helpful for identification of oxyresveratrol analogues as a putative anti-inflammatory agent.

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The phytochemical and anti‐inflammatory studies of Dillenia suffruticosa leaves

Cited by 14 publications

References 61 publications

Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

The health benefits of santol fruits and bioactive products isolated from Sandoricum koetjape Merr.: A scoping review

Computational Analysis and Biological Activities of Oxyresveratrol Analogues, the Putative Cyclooxygenase-2 Inhibitors

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