The phytochemical analysis and antioxidant activity assessment of orange peel (<i>Citrus sinensis</i>) cultivated in Greece–Crete indicates a new commercial source of hesperidin

Kanaze, Feras Imad; Termentzi, Aikaterini; Gabrieli, Chrysi; Niopas, Ioannis; Georgarakis, M.; Kokkalou, Eugene

doi:10.1002/bmc.1090

Cited by 81 publications

(56 citation statements)

References 41 publications

(54 reference statements)

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“…However, this variety also contains pentamethoxyflavone. Whereas, Kanaze et al [48] found in Navel orange peel five flavanones (hesperidin, neohesperidin, naringin, didymin), three glycosylated flavones (leuteolin-7-O-rutinoside, chrysoeriol-7-O-rutinoside diosmin),polymethoxylated flavones (sinensetin, nobiletin, hexamethoxyflavone heptamethoxyflavone). Moreover, Toledo-Guillén et al [44] identified in orange peel extracts glycosylated flavanones (hesperidin, narirutin) and the polymethoxyflavones (sinensetin, nobiletin, tetramethylscutellarein and tangeretin).…”

Section: Identification and Quantification Of Orange Peel Flavonoids mentioning

confidence: 98%

Comparison of the Efficiency of Different Extraction Methods on Antioxidants of Maltease Orange Peel

Boudhrioua¹

2016

IJFNS

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The effect of conventional solvent extraction, CSE, ultrasound assisted extraction, UAE, microwave assisted extraction, MAE and supercritical CO 2 extraction, SC-CO 2 on the total phenols content, total flavonoids, individual flavonoids and antioxidant activity of orange peel were compared. Neohesperidin (from 0.624 ± 0.013 for SC-CO 2 extraction to 1.045 ± 0.001 g100 g orange peel powder for MAE) and hesperidin (from 0.407 ± 0.008 for SC-CO 2 extraction to 0.836 ± 0.029 g/100 g orange peel powder for UAE) are the major flavonoids (80% of total flavonoids by MAE and 87% by CSE) of orange peel whatever the used extraction method. The method giving the highest total phenol and flavonoid contents is microwave assisted extraction (2.363 ± 0.014 g GAE/100g orange peel powder), followed by ultrasound assisted extraction, conventional solvent extraction, and supercritical CO 2 extraction. However, antioxidant activity (DPPH method) cannot be correlated to TPC, TFC or individual flavonoids. Orange peel extracted by CSE (ethanol (80%), m/v: 5 g:50 ml, 30 min, 35°C, mechanical stirring at darkness, 3 successive extractions) presents the higher radical scavenging capacity compared to the other extracts obtained by MAE (Ethanol (80%), m/v: 5 g: 50 ml, 10s, 35°C, 170 W, 3 successive extractions) and UAE (ethanol (80%), m/v: 5g:50 ml, 30 min, 35°C, magnetic stirring at darkness, 3 successive extractions, 125W), SC-CO 2 extraction (ethanol (80%), m/v:5 g:50 ml, 30 min, 35°C, 22 MPa, 3 successive extractions). Besides, no additivity on the antioxidant activity is found with the DPPH method.

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Section: Identification and Quantification Of Orange Peel Flavonoids mentioning

confidence: 98%

Comparison of the Efficiency of Different Extraction Methods on Antioxidants of Maltease Orange Peel

Boudhrioua¹

2016

IJFNS

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“…Consequently Citrus essential oils are extensively used in pharmaceutics as an antimicrobial, anti-diabetic, antioxidant, insect repellent, carminative, larvicidal, antiviral, antihepatotoxic and antimutagenic agent (Kanaze et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Phytochemistry, GC-MS Analysis, Antioxidant and Antimicrobial Potential of Essential Oil From Five Citrus Species

Javed¹,

Javaid²,

Nawaz³

et al. 2014

JAS

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Citrus essential oils were extraction from hydro distillation technique yielding Citrus oil with reasonable yield. Phytochemical screening of all five Citrus oils showed that alkaloids, tannins, sterols, terpenoids, saponoins, flavonoids were present (50-80%). GC/MS analysis showed highest percentage of limonene (58-89%) in Citrus oils. Antioxidant study revealed that Citrus peel oils have strong scavenging activity (83%-91%). Antimicrobial activity was evaluated by agar well method against eight common pathogens depicted marked antimicrobial potential especially tangerine (4.9-1.9 cm inhibition zones) and grapefruit oil (4.5-1.2 cm) inhibition zones. The studies emphasized the therapeutic and commercial utilization of Citrus peel essential oils as food preservatives, phytomedicine and antioxidant agent.

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“…Khaki et al investigated the effects of Basil on spermatogenesis in rats and showed that total sperm count has been improved (23). Kanaze et al in a research on Citrus reported improvement in total motility of sperms and also increase in total antioxidant capacity (TAC) and SOD and decrease in MDA levels (25). Khaki et al investigated onion's effect on spermatogenesis in rats infected by the Toxoplasma gondii, and indicated that the fresh extract of onion had potent antioxidant effect and improved all parameters of sperm like, quantity, motility and vitality (21).…”

Section: Discussionmentioning

confidence: 99%

“…The purpose of this article is to address effects of war and poverty on the health of reproduction of women and to offer scientific contribution and solutions. Keywords: Poverty, Reproductive health, War vitamins, flavonoids and minerals have significant effects on oligospermia, regulation of blood testosterone levels, increased levels of superoxide dismutase (SOD) and decreased levels of malondialdehyde (MDA) (20)(21)(22)(23)(24)(25)(26)(27)(28). So, it is possible that a combination of above mentioned herbs can show synergistic and considerable effects than the individual components.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Compound Herbal Remedy Used in Male Infertility on Spermatogenesis and Pregnancy Rate

Ouladsahebmadarek¹,

Giasi²,

Khaki³

et al. 2015

IJWHR

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IntroductionInfertility is defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse which involves 10%-15% of couples. Male factor is responsible for 40% of infertility cases. The leading cause of male infertility is impaired sperm production caused by various factors such as infections, genetic disorders, medications, aging, social and environmental factors (1-5). Oxidative damage due to free radicals is one of the major causes of idiopathic oligospermia, even with undesirable impact on the structure of sperm produces abnormal sperm. For example, in diabetic patients by producing reactive oxygen species (ROS), free radicals of nitric oxide cause oxidative stress and thus result in testicular insufficiency through affecting spermatogenesis and estrogenic pathways (6-8). Varicocele which has been observed in 19% to 41% of infertile men is a common cause of male infertility (9-11). Increased levels of ROS and oxidative levels (oxidative stress) is one of the proposed mechanisms for impaired spermatogenesis. Vacuole formation in testis tissue is a sign of oxidative stress and is associated with aging which can be neutralized by antioxidants (12)(13)(14)(15). Lack of vitamin A, elements such as flavonoids, carnitine, folate, zinc and selenium and overall reduction of antioxidants in the diet can be one of the reasons for infertility especially oligospermia and asthenozoospermia in humans (16-18). Antioxidants like vitamin E, vitamin C, glutathione, coenzyme Q10 and natural polyphenols such as flavonoids and phenolic acids by reducing the damage caused by free radicals, strengthening blood-testis barrier and protecting and repairing sperm DNA, are effective in the treatment of male infertility (19-21). Assisted reproductive techniques (ART) such as in vitro fertilization (IVF), zygote intra-fallopian transfer (ZIFT) and intra-cytoplasmic sperm insemination (ICSI) has solved many problems of infertility; however, due to high cost, they are not affordable by many of infertile couples. On the other hand, there are effective medications which are less expensive and available for a wide range of couples. The bioactive compounds in plant extracts are highly regarded because it is derived from natural sources and compatible with vital systems. Using herbal medicine to increase fertility and improve factors such as hormonal imbalance, oligospermia, low motility of sperm, prostatitis, varicocele, etc has been considered for a long time. Previous studies on laboratory animals indicated that plants such as Allium cepa, Zingiber officinale, Ocimum basilicum, Cinnamomum verum, Citrus sinensis' peel, Citrullus lanatus and Daucus carota' seeds as a rich source of Abstract Objectives: TNowadays, male infertility is one of the most common issues in the medical field and the main reason for it is impaired sperm production. Assisted Reproductive Techniques (ARTs) used for treatment of infertile couples are too costly. Currently, using herbal medicine due to lower side effe...

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The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece–Crete indicates a new commercial source of hesperidin

Cited by 81 publications

References 41 publications

Comparison of the Efficiency of Different Extraction Methods on Antioxidants of Maltease Orange Peel

Comparison of the Efficiency of Different Extraction Methods on Antioxidants of Maltease Orange Peel

Phytochemistry, GC-MS Analysis, Antioxidant and Antimicrobial Potential of Essential Oil From Five Citrus Species

The Effect of Compound Herbal Remedy Used in Male Infertility on Spermatogenesis and Pregnancy Rate

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