The Physiology of Neurogenic Obesity: Lessons from Spinal Cord Injury Research

Abstract

<b><i>Background:</i></b> A spinal cord injury (SCI) from trauma or disease impairs sensorimotor pathways in somatic and autonomic divisions of the nervous system, affecting multiple body systems. Improved medical practices have increased survivability and life expectancy after SCI, allowing for the development of extensive metabolic comorbidities and profound changes in body composition that culminate in prevalent obesity. <b><i>Summary:</i></b> Obesity is the most common cardiometabolic component risk in people living with SCI, with a diagnostic body mass index cutoff of 22 kg/m<sup>2</sup> to account for a phenotype of high adiposity and low lean mass. The metameric organization of specific divisions of the nervous system results in level-dependent pathology, with resulting sympathetic decentralization altering physiological functions such as lipolysis, hepatic lipoprotein metabolism, dietary fat absorption, and neuroendocrine signaling. In this manner, SCI provides a unique opportunity to study in vivo the “neurogenic” components of certain pathologies that otherwise are not readily observable in other populations. We discuss the unique physiology of neurogenic obesity after SCI, including the altered functions mentioned above as well as structural changes such as reduced skeletal muscle and bone mass and increased lipid deposition in the adipose tissue, skeletal muscle, bone marrow, and liver. <b><i>Key Message:</i></b> The study of neurogenic obesity after SCI gives us a unique neurological perspective on the physiology of obesity. The lessons learned from this field can guide future research and advancements to inform the study of obesity in persons with and without SCI.

2024 Wheelchair Compendium of Physical Activities: An update of activity codes and energy expenditure values

“…Wheelchair users commonly report low levels of habitual PA 9 , 10 and a heightened prevalence of cardiovascular disease risk factors. 11 , 12 Contemporary research has underscored the multifaceted benefits of PA for wheelchair users, ranging from improved cardiometabolic health and increased muscle strength and fitness 13 , 14 , 15 to positive impacts on mood and overall quality of life. 16 Consequently, regular PA is vital for wheelchair users.…”

The Impact of Caregiver/Care-Receiver Co-Treatment in a Therapeutic Lifestyle Intervention for Chronic Spinal Cord Injury: A Comparative Case Series

“…A significant contributing factor to CMD in chronic SCI is the complex interplay of physical inactivity [1,2] altered body composition [3][4][5][6], and metabolic dysfunction [7,8] due to the neurological impairment. The resultant prevalence of conditions such as obesity [9][10][11], dyslipidemia [12][13][14][15], and insulin resistance [16][17][18], which often cluster into so-called cardio metabolic syndrome, constitute leading causes of mortality and morbidity in the population. Consequently, interventions for chronic SCI have also significantly evolved over time, where rehabilitation strategies initially focused on maximizing functional recovery through task-specific training [19], current approaches prioritize a multidisciplinary strategy [20].…”