The Physiology of Human Survival

Skin capillary blood flow in scleroderma

“…This difference in skin temperatures was apparent despite the observations that (a) heat input (assessed from the area under the oral temperature curve) and oral temperatures were the same in both groups, and (b) cutaneous blood flow estimated from 'Xe clearance was also similar in the two groups. These data raise the possibility that the skin of patients with scleroderma has abnormal thermal properties which change the relationship between skin temperature and the skin blood flow observed in normal skin (20). The cool room temperature (18'C) chosen for the present study and held constant to insure thermocouple accuracy, would accentuate any dissociation between skin temperature and skin blood flow which might exist in scleroderma subjects; these conditions might explain why this observation has not been made in earlier studies (3).…”

“…When no further increase in oral temperature had occurred for 8-12 min, a second 1"Xe injection was carried out at the comparable site on the untested hand. The arm remained in the water bath while the second '3Xe injection was monitored (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) …”

The Effect of Temperature on the Action of Drugs

“…Many proceedings of symposia and review articles have been published since 1960 on the mechanism of temperature regulation and the physiological effects of heat and cold (13,33,51,52,55,76,94) and on temperature regulation and drugs (77,83,108,109). In the same period, publications dealing with the specific problems of alteration of drug action by temperature or climate in man are rare (39,41).…”

“…A different approach to the problem dealing exclusively with the sensitivity of laboratory animals is pre sented in the reviews by Laroche (75) and Ellis (34). All these reviews deal chiefly with experiments on animals which demonstrated striking effects of heat and cold on drug toxicity.Many proceedings of symposia and review articles have been published since 1960 on the mechanism of temperature regulation and the physiological effects of heat and cold (13,33,51,52,55,76,94) and on temperature regulation and drugs (77,83,108,109). In the same period, publications dealing with the specific problems of alteration of drug action by temperature or climate in man are rare (39,41).…”

Nutrition Problems and Adaption of Migrants in a New Cultural Environment*

“…JOHNSDN and KARK (1947) report a close inverse relationship between daily calorie intakes and mean environmental temperature. These, and other effects (see MITCHELL and EDMAN 1951;and EDHOLM and BACHARACH 1965) may be significant with regard to seasonal migration of manual laborers, for whom dietary compensation may be required to mitigate the effects of climate change. although C.A.C.E.…”