“…Within recent years, there have appeared a number of reviews dealing with the antagonistic interrelations among various microorganisms; some of these have dealt with certain specific groups, and others with a great variety of organisms. It is sufficient to mention Holman (155), Buchanan and Fulmer (41), and Nakhimovskaia (231) on bacterial associations, Seitz (303) on mixed infections, Brown (40), Novogrudsky (240), Weindling (355), Porter and Carter (261) and D'Aeth (64) on competition among fungi, Gaxrett (118) and Garrard and Lochhead (114) on the interrelations between soil-borne and disease-producing fungi, Nakhimovskaia (230) on antagonisms between actinomycetes and bacteria, and Waksman (345) on associations and antagonisms among micro6rganisms in different habitats. In this review, an attempt is made to present the broad antagonistic relations between micro'organisms living in association, either in simple mixed cultures or in complex natural populations; the significance of these associations in natural processes; their relation to disease production in man as well as in domesticated plants and animals; the chemical nature of the active substances produced; and finally, the nature of the antagonistic action.…”