The Physiology and Clinical Significance of the Uterine Isthmus

Mann, Edward C.; Mclarn, William D.; Hayt, David B.

doi:10.1097/00006254-196106000-00007

Cited by 5 publications

(3 citation statements)

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“…A sphincter function has been ascribed to the rat cervix in regulating uterine fluid discharge into the vagina (Blandau, 1945;Armstrong, 1968) and to the human isthmus in regulating the isthmal canal diameter (Asplund, 1952;Mann, McLaren & Hayt, 1961). Three further criteria can be applied to define a sphincter region.…”

Section: Discussionmentioning

confidence: 99%

THE INNERVATION OF THE RATCERVIX AND ITS PHARMACOLOGY In vitro AND In vivo

Hollingsworth

1974

British J Pharmacology

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1Contractions of the rat cervix and uterine horns were measured both in vitro and in vivo as changes in luminal perfusion pressure during perfusion at constant flow. 2 Spontaneous cervical and uterine horn contractions in vitro were reduced from rats pre-treated with 1701-oestradiol compared to those ovariectomized only or those pre-treated with 1703-oestradiol plus progesterone.3 The rat cervix exhibited similar in vitro sensitivities to methacholine, oxytocin, isoprenaline and phenylephrine as did the uterine horns. 4 Transmural stimulation produced cervical and uterine horn contractions, which were blocked by hyoscine or tetrodotoxin, suggesting a cholinergic motor innervation. This was supported by histological findings. 5In vivo, the injections of propranolol (1.9 x 10-7mol/kg) or pempidine (3.2 or 6.4 x 10-6 mol/kg) were followed by large cervical and smaller uterine horn contractions, suggesting an adrenergic inhibitory tone mediated by 3-adrenoceptors. 6 The evidence for a cervical sphincter is discussed.

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Section: Discussionmentioning

confidence: 99%

THE INNERVATION OF THE RATCERVIX AND ITS PHARMACOLOGY In vitro AND In vivo

Hollingsworth

1974

British J Pharmacology

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“…At present, very little is known about the development of isthmic hypotonia, but further research on the functioning of the uterine isthmus is now in progress. 17 In any event, these 9 women had a demonstrable impairment. The same total score which distinguished the habitual aborters without demonstrable pathologic changes from the comparison patients also discriminated between ha- bitual aborters with and without an identifiable organic basis for the abortions.…”

Section: Habitual-abortion and Comparison Groupsmentioning

confidence: 92%

“…17 Isthmic hypotonia was diagnosed preconceptionally by balloon studies, and cervical incompetence was confirmed by the observation of prolapsed membranes in the following pregnancy. The data obtained from these 9 patients have been treated separately, and hence the analyses of the group hereafter referred to as "habitual-abortion group" will be based on the remaining 61 cases.…”

Section: Subjectsmentioning

confidence: 99%