The Physiological Role of the Lymphoid System. VI. The Stimulatory Effect of Leucophilic γ-Globulin (Leucokinin) on the Phagocytic Activity of Human Polymorphonuclear Leucocyte<sup>*</sup>

Fidalgo, B. V.; Najjar, Victor A.

doi:10.1021/bi00863a008

Cited by 59 publications

(15 citation statements)

References 6 publications

(1 reference statement)

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“…The stimulatory e#ect of the tetrapeptide, tuftsin (Thr-Lys-Pro-Arg) on mammalian phagocytes (monocytes, macrophages, granulocytes) has been well documented (Fidalgo & Najjar, 1967;Najjar & Nishioka, 1970;Tzehoval et al, 1978). The antimicrobial and antitumour activities of this peptide has also been reported (Nishioka et al, 1981).…”

Section: Discussionmentioning

confidence: 99%

The stimulatory effect of a muscle protein hydrolysate from Atlantic cod,Gadus morhuaL., on Atlantic salmon,Salmo salarL., head kidney leucocytes

Bøgwald

Dalmo

Leifson

et al. 1996

Fish & Shellfish Immunology

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Section: Discussionmentioning

confidence: 99%

The stimulatory effect of a muscle protein hydrolysate from Atlantic cod,Gadus morhuaL., on Atlantic salmon,Salmo salarL., head kidney leucocytes

Bøgwald

Dalmo

Leifson

et al. 1996

Fish & Shellfish Immunology

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“…Leukophilic fractions I and IV are yG, as identified by immunodiffusion and immunoelectrophoresis (48). Fraction I is the least basic and fraction IV the most basic of the four fractions.…”

Section: Victormentioning

confidence: 94%

“…From Fidalgo and Naijar (48). cytophilic y-globulin with the respective cell reached completion within 1 min.…”

Section: Victormentioning

confidence: 99%

The Physiological Role of γ‐Globulin

Najjar¹

1974

Advances in Enzymology - And Related Areas of Molecular Biology

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“…Several reports have since appeared indicating the importance of this fraction in man. It was named leukokinin, and its action was well documented (2)(3)(4). Najjar and Nishioka (3) showed that the phagocytosis-stimulating effect of leukokinin is due to a single peptide fragment, liberated from the globulin by leukoDr.…”

Section: Introductionmentioning

confidence: 99%

The effect of Tuftsin on the nitrous blue tetrazolium reduction of normal human polymorphonuclear leukocytes.

Spirer¹,

Zakuth²,

Golander³

et al. 1975

J. Clin. Invest.

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A B S T R A C T The influence of Tuftsin, the synthetic phagocytosis-stimulating tetrapeptide (L-threonyl-L-lysyl-L-prolyl-L-arginine), on the nitrous blue tetrazolium (NBT) reduction by human polymorphonuclear leukocytes was investigated. It was found that this substance increases the NBT reduction by approximately as much as endotoxin. Other tetrapeptides do not share this property. When Tuftsin analogs are added to the cell suspension and incubated, they prevent the action of both Tuftsin and endotoxin but not of methylene blue. When washed of the analogs, the cells regain the property to be activated by both Tuftsin and endotoxin. It appears that methylene blue on one hand and Tuftsin and endotoxin on the other hand have different sites for their actions. We suggest that whereas methylene blue diffuses into the cell and acts directly upon the hexosemonophosphate shunt activation, Tuftsin and endotoxin appear to act on the cell membrane binding to specific receptors. By treating the cells with Tuftsin analogs, we probably block these receptors.

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The Physiological Role of the Lymphoid System. VI. The Stimulatory Effect of Leucophilic γ-Globulin (Leucokinin) on the Phagocytic Activity of Human Polymorphonuclear Leucocyte^*

Cited by 59 publications

References 6 publications

The stimulatory effect of a muscle protein hydrolysate from Atlantic cod,Gadus morhuaL., on Atlantic salmon,Salmo salarL., head kidney leucocytes

The stimulatory effect of a muscle protein hydrolysate from Atlantic cod,Gadus morhuaL., on Atlantic salmon,Salmo salarL., head kidney leucocytes

The Physiological Role of γ‐Globulin

The effect of Tuftsin on the nitrous blue tetrazolium reduction of normal human polymorphonuclear leukocytes.

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The Physiological Role of the Lymphoid System. VI. The Stimulatory Effect of Leucophilic γ-Globulin (Leucokinin) on the Phagocytic Activity of Human Polymorphonuclear Leucocyte*

Cited by 59 publications

References 6 publications

The stimulatory effect of a muscle protein hydrolysate from Atlantic cod,Gadus morhuaL., on Atlantic salmon,Salmo salarL., head kidney leucocytes

The stimulatory effect of a muscle protein hydrolysate from Atlantic cod,Gadus morhuaL., on Atlantic salmon,Salmo salarL., head kidney leucocytes

The Physiological Role of γ‐Globulin

The effect of Tuftsin on the nitrous blue tetrazolium reduction of normal human polymorphonuclear leukocytes.

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Product

Resources

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The Physiological Role of the Lymphoid System. VI. The Stimulatory Effect of Leucophilic γ-Globulin (Leucokinin) on the Phagocytic Activity of Human Polymorphonuclear Leucocyte^*