The physiological role of copper and the problems of copper nutritional deficiency

Wachnik, A

doi:10.1002/food.19880320811

Cited by 21 publications

(13 citation statements)

References 41 publications

(6 reference statements)

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“…Thus, the safe and adequate Zn/Cu relation ranges from 5 : 1 up to 10 : 1. The balanced intake of Zn and Cu is important because of the antagonistic effect of high levels of Zn on the absorption rate of Cu and consequently on the Fe metabolism [1,5,15,16]. Such an imbalance can be provoked by Zn supplementation or by therapeutic dosages of Zn to patients with classical acrodermatitis enteropathia while dietary Zn did not influence Cu retention in healthy persons [17] except in the case of Zncontaminated foods.…”

Section: Resultsmentioning

confidence: 99%

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Wheat flour confectionery products as a source of inorganic nutrients: Zinc and copper contents in hard biscuits

Šebečić

Vedrina‐Dragojević²

2004

Nahrung

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Cereal‐based confectionery products being consumed through whole human life are considered mainly to be a source of carbohydrates, that is energy, although cereals are a rich source of minerals as well. To evaluate some hard biscuits produced in Croatia as a source of different trace elements in nutrition, in this study Zn and Cu contents were determined in classic wheat flour biscuits and in dietetic biscuits enriched with whole wheat grain flour or whole wheat grain grits, soya flour and skimmed milk. Zn was determined by flame atomic absorption spectrometry (AAS); Cu was determined by inductively coupled plasma atomic emission spectroscopy (ICP‐AES). The results show that the Zn content in different kinds of biscuits ranges from 5.89 up to 17.64 mg/kg and the Cu content ranges from 1.15 up to 2.79 mg/kg depending on the type of wheat milling products and mineral content of other ingredients used. Enriched dietetic biscuits produced from wheat flour type 850 and whole wheat grain flour and/or soya flour and skimmed milk were almost 200% and 150% higher in Zn and Cu, respectively, in comparison to classic white wheat flour biscuits and can be considered as good sources of Zn and Cu in nutrition.

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Section: Resultsmentioning

confidence: 99%

“…Symptoms of copper deficiency include hypercholesterolemia (increase of the ratio of saturated to monounsaturated fatty acids), demineralization of bones and fragility of large arteries (defect in collagen and elastin formation), leucopenia, anemia (due to inhibited iron metabolism), demyelization of neural tissue, depigmentation, and growth failure [1,4,5].…”

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confidence: 99%

Wheat flour confectionery products as a source of inorganic nutrients: Zinc and copper contents in hard biscuits

Šebečić

Vedrina‐Dragojević²

2004

Nahrung

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“…Copper is an essential trace element required as a cofactor for enzymes involved in numerous important cellular functions and pathways (1,2). The importance of copper, combined with the damaging nature of copper-induced free radical activity, has imposed evolutionary constraints on the mechanisms controlling copper homeostasis at the cellular level so that key cop-per regulatory proteins have been strongly conserved throughout animal evolution (3,4).…”

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confidence: 99%

“…Although most mutations in the ATP7A gene cause Menkes disease, some missense mutations cause a milder disease called occipital horn syndrome (OHS). 2 OHS patients suffer from the connective tissue abnormalities common to Menkes disease patients but do not usually present with neurological symptoms and have a considerably longer average lifespan (13,14).…”

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confidence: 99%

In Vivo Modeling of the Pathogenic Effect of Copper Transporter Mutations That Cause Menkes and Wilson Diseases, Motor Neuropathy, and Susceptibility to Alzheimer's Disease

Mercer

Wang

Burke

2017

Journal of Biological Chemistry

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Copper is an essential biometal, and several inherited diseases are directly associated with a disruption to normal copper homeostasis. The best characterized are the copper deficiency and toxicity disorders Menkes and Wilson diseases caused by mutations in the p-type Cu-ATPase genes and, respectively. Missense mutations in the C-terminal portion of have also been shown to cause distal motor neuropathy, whereas polymorphisms in are associated with increased risk of Alzheimer's disease. We have generated a single, model for studying multiple pathogenic mutations in ATP7 proteins using, which has a single orthologue of ATP7A and ATP7B. Four pathogenic mutations and two mutations were introduced into a genomic rescue construct containing an in-frame C-terminal GFP tag. Analysis of the wild type transgene confirmed that ATP7 is expressed at the basolateral membrane of larval midgut copper cells and that the transgene can rescue a normally early lethal deletion allele to adulthood. Analysis of the transgenes containing pathogenic mutations showed that the function of ATP7 was affected, to varying degrees, by all six of the mutations investigated in this study. Of particular interest, the ATP7B Alzheimer's disease susceptibility allele was found, for the first time, to be a loss of function allele. This system allows us to assess the severity of individual/ mutations in an invariant genetic background and has the potential to be used to screen for therapeutic compounds able to restore function to faulty copper transport proteins.

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“…TO evaluate the ecotoxicity of the metals in a water body, the measurement of such a fraction is often critical (Wachnik 1988;Jonnalagadda and Rao 1993). A number of methods, including anodic stripping voltammetry have been developed for collecting information on metal speciation.…”

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confidence: 99%

Long-Term Monitoring of Bioavailable Copper in the Aquatic Environment Using a Resin-Filled Dialysis Membrane

Tao

Liang

1997

Bulletin of Environmental Contamination and Toxicology

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It has been demonstrated that only a relatively small portion of the total amount of metals in an aquatic system is biologically available. TO evaluate the ecotoxicity of the metals in a water body, the measurement of such a fraction is often critical (Wachnik 1988;Jonnalagadda and Rao 1993). A number of methods, including anodic stripping voltammetry have been developed for collecting information on metal speciation. None of them, however, can measure the biologically available fraction for routine monitoring purposes. This is due to both extremely low concentrations of such a fraction and shift of the equilibrium among species during the analysis (Tao 1987). Furthermore, most efforts on metal speciation have focused on the determination of the available metal concentration in a single grab sample. The level of individual species may, however, fluctuate randomly.The information on the overall bioavailability of the metals over a relatively long period of time is necessary for ecotoxicity assessment. This, however, cannot be provided by measured results from a limited number of samples collected individually. Sodergren (1987) used a dialysis membrane filled with organic solvent to simulate the absorption of organic pollutants by an organism. This technique was applied to predict the levels of bioavailable lipophilic pollutants in organisms and to study bioaccumulation mechanisms in aquatic environments (Sodergren 1990). A similar approach using dialysis with receiving resins was reported by Morrison (1987). A cellulose dialysis membrane, with a molecular weight cut-off of 1000 dalton, filled with Chelex-100 chelating resin was employed to simulate the slow membrane-limited metal transport process across a cell membrane. The method was tested for urban stormwater and other polluted waters. The membrane uptake rate, receiving resin uptake rate, as well as the relationship between metal uptake and rainfall duration were investigated. It was found that the metal uptake rates measured at three stormwater outfalls reflected the sporadic and variable nature of bioavailable metals in stormwater discharge (Morrison 1987(Morrison , 1989. The dialysisresin technique has also been employed to determine the free-ion fraction of cadmium in water samples (Berggren 1990). The purpose of the study was to measure the instant concentration of a single sample. Information on overall bioavailability of the metals cannot be provided by this approach.

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The physiological role of copper and the problems of copper nutritional deficiency

Cited by 21 publications

References 41 publications

Wheat flour confectionery products as a source of inorganic nutrients: Zinc and copper contents in hard biscuits

Wheat flour confectionery products as a source of inorganic nutrients: Zinc and copper contents in hard biscuits

In Vivo Modeling of the Pathogenic Effect of Copper Transporter Mutations That Cause Menkes and Wilson Diseases, Motor Neuropathy, and Susceptibility to Alzheimer's Disease

Long-Term Monitoring of Bioavailable Copper in the Aquatic Environment Using a Resin-Filled Dialysis Membrane

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