The Physiological Role and Regulation of Aquaporins in Teleost Germ Cells

Cerdà, Joan; Chauvigné, François; Finn, Roderick Nigel

doi:10.1007/978-94-024-1057-0_10

Cited by 23 publications

(16 citation statements)

References 110 publications

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“…The above findings for Teleostei primarily addressed the glp repertoires of diploid species. For the teleost lineages that experienced R4, the data for allotetraploid cyprinids were fully consistent with the previous reports for the common carp ( Cyprinus carpio ) in which the glp copy number is double (13–14 paralogs) that of zebrafish (7 paralogs) [ 68 , 74 ]. In the present context, however, the aqp10 genes were renamed aqp10aa and -10bb in diploid cyprinids and aqp10aa1 , -10aa2 , -10bb1 and -10bb2 in allotetraploid cyprinids.…”

Section: Resultssupporting

confidence: 89%

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Unravelling the Complex Duplication History of Deuterostome Glycerol Transporters

Yilmaz

Chauvigné

Ferré

et al. 2020

Cells

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Transmembrane glycerol transport is an ancient biophysical property that evolved in selected subfamilies of water channel (aquaporin) proteins. Here, we conducted broad level genome (>550) and transcriptome (>300) analyses to unravel the duplication history of the glycerol-transporting channels (glps) in Deuterostomia. We found that tandem duplication (TD) was the major mechanism of gene expansion in echinoderms and hemichordates, which, together with whole genome duplications (WGD) in the chordate lineage, continued to shape the genomic repertoires in craniates. Molecular phylogenies indicated that aqp3-like and aqp13-like channels were the probable stem subfamilies in craniates, with WGD generating aqp9 and aqp10 in gnathostomes but aqp7 arising through TD in Osteichthyes. We uncovered separate examples of gene translocations, gene conversion, and concerted evolution in humans, teleosts, and starfishes, with DNA transposons the likely drivers of gene rearrangements in paleotetraploid salmonids. Currently, gene copy numbers and BLAST are poor predictors of orthologous relationships due to asymmetric glp gene evolution in the different lineages. Such asymmetries can impact estimations of divergence times by millions of years. Experimental investigations of the salmonid channels demonstrated that approximately half of the 20 ancestral paralogs are functional, with neofunctionalization occurring at the transcriptional level rather than the protein transport properties. The combined findings resolve the origins and diversification of glps over >800 million years old and thus form the novel basis for proposing a pandeuterostome glp gene nomenclature.

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Section: Resultssupporting

confidence: 89%

“…In past studies of teleost glps , the AQP10 orthologs were found to have duplicated and were named aqp10a and -10b to reflect their presumed R3 origins [ 35 , 36 , 40 , 66 , 67 , 68 ]. In the present study, however, we found a more complex heritage of these genes.…”

Section: Resultsmentioning

confidence: 99%

Unravelling the Complex Duplication History of Deuterostome Glycerol Transporters

Yilmaz

Chauvigné

Ferré

et al. 2020

Cells

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“…However, in the case of Glp1_v2 and Glp3_v1, which derive from the distantly related A and B clusters, respectively, there is redundant expression in the same enterocytes, but they are not colocated in the plasma membrane. Indeed the intracellular localization of Glp1_v2 in the enterocytes was also seen in the female oocytes in a pattern that is highly reminiscent of Aqp1ab in marine teleost oocytes [41][42][43] .…”

Section: Discussionmentioning

confidence: 87%

Lineage-level Divergence of Copepod Glycerol Transporters and the Emergence of Isoform-specific Trafficking Regulation

Catalán-García

Chauvigne

Stavang

et al. 2020

Preprint

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Transmembrane conductance of glycerol is typically facilitated by aquaglyceroporins (Glps), which are commonly encoded by multiple genes in metazoan organisms. To date, however, little is known concerning the evolution of Glps in Crustacea or what forces might underly such gene redundancy. Here we show that Glp evolution in Crustacea is highly divergent, ranging from single copy genes in species of tadpole shrimps, isopods, amphipods and decapods to up to 10 copies in diplostracan water fleas although with monophyletic origins in each lineage. By contrast Glp evolution in Copepoda appears to be polyphyletic, with high rates of gene duplication occurring in a genera- and species-specifc manner. Based upon functional experiments on the Glps from a parasitic copepod (Lepeophtheirus salmonis), we show that such lineage-level gene duplication and splice variation is coupled with a high rate of neofunctionalization. For L. salmonis, splice variation of a given gene resulted in tissue- or sex-specific expression of the channels, with each variant evolving unique sites for PKC or PKA regulation of intracellular membrane trafficking. The data thus reveal that mutations favouring a high fidelity control of intracellular trafficking regulation can be a selection force for the evolution and retention of multiple Glps in copepods.

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“…In fish, several works have found that AQPs are involved in the regulation of sperm motility. Readers are referred to elegant and very recent reviews (Boj, Chauvigné, & Cerdà, ; Cerdà, Chauvigné, & Finn, ).…”

Section: Aqps In Non‐mammalian Speciesmentioning

confidence: 99%

Aquaporins in the male reproductive tract and sperm: Functional implications and cryobiology

Yeste

Morató

Rodríguez-Gil

et al. 2017

Reprod Domestic Animals

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Contents Aquaporins (AQPs) play a vital role for the transport of water and solutes across cell membranes. Classification of these ubiquitous proteins into three categories (orthodox AQPs, aquaglyceroporins and superaquaporins) is based on their sequence similarity and substrate selectivity. In the male reproductive tract of mammals, most AQPs (except AQP6 and AQP12) are found in different organs (including testis, efferent ducts and epididymis). AQP1 and AQP9 are the most abundant AQPs in the efferent ducts and epididymis and play a crucial role for the secretion/reabsorption dynamics of luminal fluid during sperm transport and maturation. AQP3, AQP7, AQP8 and AQP11 are the most abundant AQPs in sperm and are involved in the regulation of their volume, which is required for the differentiation of spermatids into spermatozoa during spermatogenesis, as well as in sperm transit along environments of different osmolality (male and female reproductive tracts). While different studies conducted in oocytes and embryos have demonstrated that AQPs are important for cryotolerance, data in sperm are scarce. At present, mounting evidence indicates that AQP3, AQP7 and AQP11 are involved in the sperm response to variations of osmolality and to freeze‐thawing procedures. All these studies contribute to understand the physiology of both male reproductive tract and sperm, and open up new research ventures on the improvement of sperm cryopreservation protocols.

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The Physiological Role and Regulation of Aquaporins in Teleost Germ Cells

Cited by 23 publications

References 110 publications

Unravelling the Complex Duplication History of Deuterostome Glycerol Transporters

Unravelling the Complex Duplication History of Deuterostome Glycerol Transporters

Lineage-level Divergence of Copepod Glycerol Transporters and the Emergence of Isoform-specific Trafficking Regulation

Aquaporins in the male reproductive tract and sperm: Functional implications and cryobiology

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