volume 5, issue 10, Pe13376 2010
DOI: 10.1371/journal.pone.0013376
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Abstract: BackgroundDiurnal behavior in humans is governed by the period length of a circadian clock in the suprachiasmatic nuclei of the brain hypothalamus. Nevertheless, the cell-intrinsic mechanism of this clock is present in most cells of the body. We have shown previously that for individuals of extreme chronotype (“larks” and “owls”), clock properties measured in human fibroblasts correlated with extreme diurnal behavior.Methodology/Principal FindingsIn this study, we have measured circadian period in human primar…

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