Research on the relations among business travel, work, and family domains has been limited. To address this issue, this study examined the influence of business travel on work-family conflict and the emotional exhaustion component of burnout, using the Job Demands-Resources perspective. The study was conducted in a large Norwegian oil and gas company, and to overcome the limitations of self-reported data on business travel frequency, the company's business travel database was utilized in the study. The response rate was 68% (n = 2093). The results revealed that business travel frequency and control over travel explained a significant proportion of the variance in work-family conflict, but not in emotional exhaustion. However, work-family conflict was found to be a mediator in the business travel-emotional exhaustion relationship. Moreover, the results revealed significant differences in work-family conflict related to travel pattern among groups of travellers, but no differences in emotional exhaustion. Commuters reported the highest degree of work-family conflict. Practical implications and the consequences of these findings for future research are discussed.