The Physiological Functions and Polymorphisms of Type II Deiodinase

Deng, Yan; Han, Yi; Gao, Sheng; Dong, Wei; Yu, Yang

doi:10.3803/enm.2022.1599

Cited by 2 publications

(1 citation statement)

References 108 publications

(118 reference statements)

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“…Although the present trial found no positive effects on clinical outcomes, such as QoL and the LT4 dosage, further research is needed to explore whether the potential effects of selenium on the immune system, the oxidative stress burden, and low-grade inflammation are of clinical significance in patients with thyroid diseases. In addition, future studies may reveal if specific gene variants predict increased responsiveness to selenium supplementation ( 47 , 48 , 49 ).…”

Section: Discussionmentioning

confidence: 99%

Selenium supplementation and placebo are equally effective in improving quality of life in patients with hypothyroidism

Bøgelund Larsen,

Winther,

Cramon

et al. 2024

European Thyroid Journal

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Purpose: We investigated whether selenium supplementation improves quality-of-life (QoL) in patients with autoimmune thyroiditis (ID:NCT02013479). Methods: We included 412 patients ≥18 years with serum thyroid peroxidase antibody (TPOAb) level ≥100 IU/mL in a multicentre double-blinded randomised clinical trial. The patients were allocated 1:1 to daily supplementation with either 200 μg selenium as selenium-enriched yeast or matching placebo tablets for 12 months, as add-on to levothyroxine (LT4) treatment. QoL, assessed by the Thyroid-related Patient-Reported-Outcome questionnaire (ThyPRO-39), was measured at baseline, after six weeks, three, six, 12, and 18 months. Results: In total, 332 patients (81%) completed the intervention period, of whom 82% were women. Although QoL improved during the trial, no difference in any of the ThyPRO-39 scales was found between the selenium group and the placebo group after 12 months of intervention. In addition, employing linear mixed model regression no difference between the two groups was observed in the ThyPRO-39 composite score (28.8 [95%CI:24.5-33.6] and 28.0 [24.5-33.1], respectively; P=0.602). Stratifying the patients according to duration of the disease at inclusion, ThyPRO-39 composite score, TPOAb level, or selenium status at baseline did not significantly change the results. TPOAb levels after 12 months of intervention were lower in the selenium group than in the placebo group (1995 [95%CI:1512-2512] vs. 2344 kIU/L [1862-2951]; P=0.016) but did not influence LT4 dosage or free triiodothyronine/free thyroxin ratio. Conclusion: In hypothyroid patients on LT4 therapy due to autoimmune thyroiditis, daily supplementation with 200 μg selenium or placebo for 12 months improved QoL to the same extent.

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Section: Discussionmentioning

confidence: 99%

Selenium supplementation and placebo are equally effective in improving quality of life in patients with hypothyroidism

Bøgelund Larsen,

Winther,

Cramon

et al. 2024

European Thyroid Journal

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Noncatalytic Reductive Deiodination of Thyroid Hormones. Electrochemistry and Quantum Chemical Calculations

Romańczyk,

Kurek

2023

ChemElectroChem

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Noncatalytic processes may occur spontaneously leading often to undesired products. Electrochemical measurements provide data for thermodynamic calculations. Cyclic voltammetry of thyroxine (T4) and 3,3’,5‐triiodothyronine (T3) in N,N‐dimethylformamide (DMF) and alkaline aqueous solutions of pH 10–14 on glassy carbon electrodes yielded the values of redox potentials for the reduction leading to deiodination of those thyroid hormones under noncatalytic conditions. The first step of T4 deiodination occurs in DMF at −1.93 V vs. Fc+/Fc and for T3 at −1.95 V, which was confirmed by quantum‐chemical calculations at DFT and DLPNO‐CCSD(T) levels. In alkaline aqueous solutions, owing to poor solubility of these compounds, it was possible to determine only approximate values equal to −1.6 to −1.7 V vs. Ag/AgCl for the first step of deiodination. The reduction potentials do not depend on pH under these conditions. As shown by calculations, further steps exhibit very close reduction potentials. The radicals formed as products of concerted dissociative electron transfer to T4 and T3 are relatively kinetically stable which leads to side reactions initiated by radicals in uncatalyzed deiodination processes.

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The Physiological Functions and Polymorphisms of Type II Deiodinase

Cited by 2 publications

References 108 publications

Selenium supplementation and placebo are equally effective in improving quality of life in patients with hypothyroidism

Selenium supplementation and placebo are equally effective in improving quality of life in patients with hypothyroidism

Noncatalytic Reductive Deiodination of Thyroid Hormones. Electrochemistry and Quantum Chemical Calculations

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