The physiological effect of acute vagal section on canine biliary dynamics

Beneventano, Thomas C.; Rosen, Richard G.; Schein, Clarence J.

doi:10.1016/0022-4804(69)90076-6

Cited by 13 publications

(4 citation statements)

References 1 publication

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“…This process may be favored by extrahepatic factors such as an increased number of intestinal microorganisms, a decreased intestinal motility, a decreased absorption in the small bowel, or an increased cycling frequency of bile acids due to alterations in biliary tract dynamics. Changes in these factors as a consequence of truncal vagotomy in dogs have been described by several investigators [Ballinger et al, 1964;Scheinin et al, 1967;Beneventano et al. 1969: Dubecz et al.…”

Section: Discussionmentioning

confidence: 99%

Effect of Selective Proximal and Truncal Vagotomy on Canine Gallbladder Bile Composition

Meijer¹,

Visser²,

Rauwerda³

et al. 1981

Eur Surg Res

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In 6 dogs the influence of consecutively a selective proximal vagotomy (SPV) and a truncal vagotomy (TV) on gallbladder bile composition was studied. Following SPV no significant changes in biliary lipids were observed. On the other hand, after TV an increase of deoxycholic acid (D) and a concomitant decrease of cholic acid (C) occurred, resulting in a marked increase of the D/C ratio. Although a positive correlation was found between the D/C ratio and the lithogenic index of bile, the change in bile acid composition after TV was accompanied with only a slight, statistically not significant increase of the lithogenic index. It is concluded that in the dog neither SPV nor TV is a definitely lithogenic procedure.

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Section: Discussionmentioning

confidence: 99%

Effect of Selective Proximal and Truncal Vagotomy on Canine Gallbladder Bile Composition

Meijer¹,

Visser²,

Rauwerda³

et al. 1981

Eur Surg Res

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“…However, normal contraction of the gall-bladder has also been reported following vagotomy (Clave and Caspar, 1969;Parkin et al, 1973) and function has also been considered to be normal (Williams and Irvine, 1966;Glanville and Duthie, 1964;Beneventano et al, 1969).…”

Section: Discussionmentioning

confidence: 99%

The Influence of Vagotomy on Bile Kinetics in the Rhesus Monkey

McMaster¹,

Medd²,

McLeish³

1979

Eur Surg Res

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An increased incidence of gallstones has been reported following truncal vagotomy and gastric drainage but never conclusively proven. In the Rhesus monkey, bile composition and flow is similar to man. A model of biliary drainage was established which permits continuous monitoring of bile kinetics. Following truncal vagotomy and pyloroplasty, a significant fall in bile acid concentration was observed, accompanied by a rise in cholesterol concentration. This resulted in an overall rise in cholesterol saturation. Similar changes in hepatic bile composition were, however, also seen following pyloroplasty alone, and suggests that the vagotomy itself may not be the important factor in producing bile changes.

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“…The mechanism responsible for postvagotomy gallstone development is uncertain, but the recent cholesterol nucleation theory 4 suggests that gallbladder (GB) bile stasis plays an important role in gallstone development by providing the time necessary for cholesterol crystal precipitation. Although numerous studies have shown that truncal vagotomy results in impaired GB emptying and dilatation, 3 , 5 –10 some earlier studies failed to demonstrate any effect of vagotomy on the GB 11 –16 . There are several possible explanations for these inconsistent findings, such as (a) species differences, (b) methodological problems, (c) the length of time after vagotomy, (d) the dose and type of GB stimulus or meal composition and (e) the type of vagotomy or completeness of the operative procedure.…”

Section: Introductionmentioning

confidence: 99%

Effect of truncal vagotomy on gallbladder bile kinetics in conscious dogs

Muramatsu

Sonobe

Tohara

et al. 1999

Neurogastroenterology Motil

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Previous studies on the effects of vagotomy on gallbladder (GB) motility have yielded conflicting results. The aim of this study was to evaluate the effects of vagotomy on GB motility and bile kinetics using a new method. Twelve dogs were divided into two groups of six (control and pyloroplasty) and, 4 weeks later, underwent truncal vagotomy. A catheter secured in the GB fundus was used to monitor GB volume. After injecting polyethylene glycol (PEG) into the GB, combined measurements of GB volume and PEG concentration enabled GB emptying and bile kinetics to be estimated. Seven and five of the 12 vagotomized dogs were classified as having large and normal fasting GB volumes, respectively. Postprandial GB emptying was impaired when the fasting GB volume was enlarged. In the fasting state, bile kinetics of vagotomized dogs were significantly smaller than the control values. The emptying ability of the GB of vagotomized dogs with large fasting GB volumes was reduced considerably both in the postprandial and the fasting states. Such retention of bile in the GB after vagotomy may facilitate cholesterol crystal nucleation and stone growth.

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The physiological effect of acute vagal section on canine biliary dynamics

Cited by 13 publications

References 1 publication

Effect of Selective Proximal and Truncal Vagotomy on Canine Gallbladder Bile Composition

Effect of Selective Proximal and Truncal Vagotomy on Canine Gallbladder Bile Composition

The Influence of Vagotomy on Bile Kinetics in the Rhesus Monkey

Effect of truncal vagotomy on gallbladder bile kinetics in conscious dogs

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