The Physiological Actions of the Hormones of the Posterior Lobe of the Pituitary Gland

Rl, Stehle

doi:10.1016/s0083-6729(08)60672-x

Cited by 7 publications

(3 citation statements)

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“…The metabolic actions of the hormones of the posterior pituitary gland have not been fully elucidated (for reviews, see Stehle, 1950;Mirsky, 1968). It has long been known that extracts of the neurohypophysiscancause hyperglycaemia (Claude &Baudouin, 1912;Clark, 1928) and prevent the hypoglycaemia due to insulin (Burn, 1923), perhaps as a result of breakdown of liver glycogen (Clark, 1928;Imrie, 1929; for discussion see Stehle, 1950). Since purer preparations of hormones became available vasopressin has been shown to bring about an increase in the concentration of blood glucose in mammals (Bergen etal., 1960;Cash & Kaplan, 1964;Schillinger et al, 1972), possibly through hepatic glycogenolysis (Bergen et al, 1960;Heidenreich et al, 1963).…”

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Stimulation by vasopressin of glycogen breakdown and gluconeogenesis in the perfused rat liver

Hems

Whitton

1973

Biochemical Journal

151

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1. Vasopressin (anti-diuretic hormone, [8-arginine]vasopressin) stimulated the breakdown of glycogen in perfused livers of fed rats, at concentrations (50-600muunits/ml) that have been reported in the blood of intact rats, especially during acute haemorrhagic shock. 2. In perfused livers from starved rats, vasopressin (30-150muunits/ml) stimulated gluconeogenesis from a mixture of lactate, pyruvate and glycerol. 3. Vasopressin prevented accumulation of liver glycogen in the perfused liver of starved rats, or in starved intact rats. 4. The action of vasopressin on hepatic carbohydrate metabolism thus resembles that of glucagon; the minimum effective circulating concentrations of these hormones are of the same order (100pg/ml). 5. The stimulation of hepatic glucose output by vasopressin is discussed in connexion with the release of glucose and water from the liver.

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Stimulation by vasopressin of glycogen breakdown and gluconeogenesis in the perfused rat liver

Hems

Whitton

1973

Biochemical Journal

151

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“…Since the action of these three drugs is equally depressed by indole and skatole, it seems likely that the latter act on the final common path of the three drugs, namely the smooth muscle fibre itself. This is confirmed by the finding that indole and skatole also inhibit the action of the pituitary oxytocic hormone on the uterus (see Stehle, 1950).…”

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confidence: 53%