The physical form of microbial ligands bypasses the need for dendritic cell migration to stimulate adaptive immunity

Abstract

A central paradigm of immunology is that the innate immune system first detects infectious agents in peripheral tissues, shortly after a pathogen has breached an epithelial barrier. This detection event is mediated by pattern recognition receptors in phagocytes, which then migrate to draining lymph nodes (dLNs), where information of a microbial encounter is conveyed to T and B lymphocytes to generate adaptive immunity. Through the study of fungal moieties, we present data that challenge this model. We found that soluble fungal polysaccharides are immunosilent in the periphery, but become potent immunogens in the dLN. These ligands completely bypass the need of phagocyte migration and, instead, directly activate an immune response that is most similar to those that typify viral infections. These data establish a class of microbial products that violate a central tenet of the immunological lexicon and illustrate that the physical form (not just the chemical structure) impacts innate and adaptive immunity. Short title (40 characters):The form of PAMPs dictates immunity

Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference

“…These fungal moieties activate an immune response similar to viral infection, without any requirement for phagocyte migration. These observations highlight how the physical form of certain PAMPs impacts innate and adaptive immunity (66).…”