The Photodynamic Properties of a Particular Hematoporphyrin Derivative

Lipson, Richard L.; Baldes, Edward J.

doi:10.1001/archderm.1960.01580040026005

Cited by 331 publications

(122 citation statements)

References 5 publications

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…The discovery that porphyrins preferentially localize and fluoresce in tumour tissue, the purification of HpD from crude hematoporphyrin [33][34][35][36][37] and the fact that it could be activated by red light led to the first trials using HpD as a PS by Thomas Dougherty's group in the 1970s. Exciting results were obtained in the treatment of cutaneous and subcutaneous malignant tumours with tumour regression being observed in 111 cases.…”

Section: History Of Pdtmentioning

confidence: 99%

New Approaches to Photodynamic Therapy from Types I, II and III to Type IV Using One or More Photons

Scherer

Bisby²,

Botchway³

et al. 2017

ACAMC

View full text Add to dashboard Cite

Photodynamic therapy (PDT) is an alternative cancer treatment to conventional surgery, radiotherapy and chemotherapy. It is based on activating a drug with light that triggers the generation of cytotoxic species that promote tumour cell killing. At present, PDT is mainly used in the treatment of wet age-related macular degeneration, for precancerous conditions of the skin (e.g. actinic keratosis) and in the palliative care of advanced cancers, for instance of the bladder or the oesophagus. Due to a lack of phase III clinical trials and limitations of light penetration to deeper lying tumours (in excess of 1 cm), PDT is still not used as a first line cancer treatment, which is surprising given the first clinical trials by Dougherty's group dating back to the 1970's. However research continues to demonstrate the potential benefits of PDT and the need to stimulate funding and uptake of clinical studies using next generation photosensitizers offering advanced targeted delivery, improved photodynamic dose combined with modern light delivery technologies. This review surveys the available PDT treatments and emerging novel developments in the field with a particular focus on two-photon techniques that are anticipated to improve the effectiveness of PDT in tissues at depth and on next generation drugs that work without the need of the presence of oxygen for photosensitization making them effective where hypoxia has taken hold.

show abstract

Section: History Of Pdtmentioning

confidence: 99%

New Approaches to Photodynamic Therapy from Types I, II and III to Type IV Using One or More Photons

Scherer

Bisby²,

Botchway³

et al. 2017

ACAMC

View full text Add to dashboard Cite

show abstract

“…The main photosensitizers currently used are haematoporphyrin derivatives, which show efficacy for the treatment of non-melanoma skin cancer [36] . Among them, the similar first generation drugsPhotofrin® [37,38] , Photogem® and Photosan® show unique characteristics, such as differences in toxicity, which make each of them ideally indicated to specific applications.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Clinical Photodynamic Therapy Review and the Brazilian Experience

et al. 2016

View full text Add to dashboard Cite

Photodynamic therapy (PDT) is a simple and promising technique indicated for the treatment of non-melanoma skin cancer. Although multicenter research trials have proved its success, PDT is not as much disseminated as surgery andcryotherapy approaches are. A light-activated substance (a photosensitizer) is usually topically administered. By irradiating the sensitized region with specific wavelengths and appropriated light dose, reactive oxygen species take place, which oxidize molecules and destroy tumor cells. This review article presents not only the base principles of PDT, but also a unique experience Brazil-wide, which reached other countries in Latin America. This initiative was funded by the Brazilian government via the Brazilian Development Bank (BNDES), involving private companies and academia in a validation study of the treatment of both pre-malignant and malignant skin cancer lesions.PDT protocol evolution is presented, including details that made the technique highly efficient and placed this experiencein a larger context.

show abstract

“…Одними из наиболее распространенных в ФДТ являются порфирин-содержащие фотосен-сибилизаторы [10][11][12][13], что обусловлено высоким квантовым выходом синглетного кислорода при фотохимических реакциях с порфиринами. Наи-более перспективным среди них оказался гема-топорфирин IX.…”

Section: Introductionunclassified

“…Наи-более перспективным среди них оказался гема-топорфирин IX. Именно на его основе Липсон с сотрудниками в 1961 году получил так называ-емое «производное гематопорфирина» [10,11], которое Т. Догерти [14] в дальнейшем применил при лечении своих первых пациентов. И сегодня в медицинской практике наиболее широко ис-пользуются препараты на основе гематопорфири-…”

Section: Introductionunclassified

Morphological Changes in Transplanted Sarcoma S45 at Photodynamic Therapy Using Nanocomposites Based on Gold Nanorods

Bucharskaya¹,

Genina²,

Bashkatov³

et al. 2015

View full text Add to dashboard Cite

The Photodynamic Properties of a Particular Hematoporphyrin Derivative

Cited by 331 publications

References 5 publications

New Approaches to Photodynamic Therapy from Types I, II and III to Type IV Using One or More Photons

New Approaches to Photodynamic Therapy from Types I, II and III to Type IV Using One or More Photons

Clinical Photodynamic Therapy Review and the Brazilian Experience

Morphological Changes in Transplanted Sarcoma S45 at Photodynamic Therapy Using Nanocomposites Based on Gold Nanorods

Contact Info

Product

Resources

About