2020
DOI: 10.1039/d0nj02975k
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The photo-/thermo-chromism of spiropyran in alkanes as a temperature abuse indicator in the cold chain of vaccines

Abstract: The optimal storage temperature for vaccines ranges from 2 to 8 °C. Electronic thermometers is able to provide real-time and remote temperature monitoring, but cannot applied to individual package. As...

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Cited by 11 publications
(9 citation statements)
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“…Hence, time–temperature indicators (TTIs), as a rising and intelligent technology, have been proposed to record the cumulative effects of time and temperature on individual products through irreversible visual responses, displaying the remaining shelf life dynamically. Over the years, various materials, including organic molecules, , noble metal nanoparticles (NPs), , microencapsulated microorganisms, enzymatic indicators, photonic crystals, and nanofibers, , have been used to prepare TTIs. However, the advanced technology of TTIs is still in its infancy because most of the above-mentioned TTIs are subject to either high cost or loss of accuracy and universality over time.…”
Section: Introductionmentioning
confidence: 99%
“…Hence, time–temperature indicators (TTIs), as a rising and intelligent technology, have been proposed to record the cumulative effects of time and temperature on individual products through irreversible visual responses, displaying the remaining shelf life dynamically. Over the years, various materials, including organic molecules, , noble metal nanoparticles (NPs), , microencapsulated microorganisms, enzymatic indicators, photonic crystals, and nanofibers, , have been used to prepare TTIs. However, the advanced technology of TTIs is still in its infancy because most of the above-mentioned TTIs are subject to either high cost or loss of accuracy and universality over time.…”
Section: Introductionmentioning
confidence: 99%
“…[8][9][10] For instance, Gao et al developed a cost-effective temperature indicator by using a spiroprotease that can melt at a T t and disperse into a mixture of n-tetradecane and n-pentadecane solvents, thus producing a color change from blue to colorless. 11 Prototype TTIs based on the Maillard reaction successfully served the purpose of monitoring the greenhouse temperature during crop cultivation by monitoring the color change from yellow to brown. 12 However, most of these materials only change from one color to another, which limits the monitoring of multiple temperatures.…”
Section: Introductionmentioning
confidence: 99%
“…21,22 Through modification, the stability, absorption, and fluorescence properties of spiropyrans can be improved. Moreover, the reversible photoluminescence of spiropyrans can be performed by the adjustment of temperature, 23,24 solvent 25,26 and acidity. 27 Monospiropyran derivatives consist of two p-systems linked by a spiro-carbon and have been employed in CN À detection.…”
Section: Introductionmentioning
confidence: 99%