2002
DOI: 10.1074/jbc.m111996200
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The Phosphotyrosine Binding-like Domain of Talin Activates Integrins

Abstract: Cellular regulation of the ligand binding affinity of integrin adhesion receptors (integrin activation) depends on the integrin ␤ cytoplasmic domains (tails). The head domain of talin binds to several integrin ␤ tails and activates integrins. This head domain contains a predicted FERM domain composed of three subdomains (F1, F2, and F3). An integrin-activating talin fragment was predicted to contain the F2 and F3 subdomains. Both isolated subdomains bound specifically to the integrin ␤ 3 tail. However, talin F… Show more

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Cited by 358 publications
(376 citation statements)
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“…47). Interestingly, among all the cytoplasmic ␤ integrin-binding proteins that had been tested, only talin had been shown to be able to promote integrin activation (24,41,48). The results presented in this study demonstrate that MIG-2 can also play a role in this process.…”
Section: Discussionmentioning
confidence: 64%
“…47). Interestingly, among all the cytoplasmic ␤ integrin-binding proteins that had been tested, only talin had been shown to be able to promote integrin activation (24,41,48). The results presented in this study demonstrate that MIG-2 can also play a role in this process.…”
Section: Discussionmentioning
confidence: 64%
“…The latter possibility is suggested by biochemical studies of ␤ integrin cytoplasmic tails demonstrating that the Y-A mutation disrupts interaction with the cytoskeletal protein talin (Calderwood et al 2002) and the observation that talin-deficient ES cells lose surface expression of ␤1 integrins (Priddle et al 1998). To address this question, mutant ␤1 integrin expression and function were next studied in homozy- Figure 1.…”
Section: Resultsmentioning
confidence: 99%
“…The ERM proteins bind via their FERM domains to the cytoplasmic domains of transmembrane proteins, e.g., CD44 (3). Other examples of FERM domain-mediated intermolecular interactions include binding of the talin FERM domain to the β subunit of integrins and the interaction of the FERM domains of Janus-activated kinases with the γc and gp130 subunits of cytokine receptors (6,7). Second, FERM domains function in either intramolecular or homophilic intermolecular interactions.…”
Section: Introductionmentioning
confidence: 99%