The Phosphoric-Esterase of Blood

Martland, Marjorie; Hansman, F. S.; Robison, Robert

doi:10.1042/bj0181152

Cited by 75 publications

(7 citation statements)

References 4 publications

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“…AcP was first described in human erythrocytes [17], and to date, at least five different AcPs have been reported in human tissues [12,18,19]. Of groundbreaking importance was work by Gutman and colleagues demonstrating the elevation of serum PAcP in advanced PCa [1].…”

Section: Biology Of Human Prostatic Acid Phosphatasementioning

confidence: 99%

Human Prostatic Acid Phosphatase: Structure, Function and Regulation

Muniyan

Chaturvedi

Dwyer

et al. 2013

IJMS

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Human prostatic acid phosphatase (PAcP) is a 100 kDa glycoprotein composed of two subunits. Recent advances demonstrate that cellular PAcP (cPAcP) functions as a protein tyrosine phosphatase by dephosphorylating ErbB-2/Neu/HER-2 at the phosphotyrosine residues in prostate cancer (PCa) cells, which results in reduced tumorigenicity. Further, the interaction of cPAcP and ErbB-2 regulates androgen sensitivity of PCa cells. Knockdown of cPAcP expression allows androgen-sensitive PCa cells to develop the castration-resistant phenotype, where cells proliferate under an androgen-reduced condition. Thus, cPAcP has a significant influence on PCa cell growth. Interestingly, promoter analysis suggests that PAcP expression can be regulated by NF-κB, via a novel binding sequence in an androgen-independent manner. Further understanding of PAcP function and regulation of expression will have a significant impact on understanding PCa progression and therapy.

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Section: Biology Of Human Prostatic Acid Phosphatasementioning

confidence: 99%

Human Prostatic Acid Phosphatase: Structure, Function and Regulation

Muniyan

Chaturvedi

Dwyer

et al. 2013

IJMS

View full text Add to dashboard Cite

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“…The full development of hemopoietic bone marrow correlated with the increased activities of lactic and malic dehydrogenases. The increasing acid phosphatase activity may be due to erythropoiesis (13), and the alkaline phosphatase activity may reflect myelopoiesis (Table II).…”

Section: Sequential Changesmentioning

confidence: 99%

Collagenous bone matrix-induced endochondral ossification hemopoiesis.

Reddi

Anderson

1976

The Journal of Cell Biology

319

117

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Transplantation of collagenous matrix from the rat diaphyseal bone to subcutaneous sites resulted in new bone formation by an endochondral sequence. Functional bone marrow develops within the newly formed ossicle. On day 1, the implanted matrix was a discrete conglomerate with fibrin clot and polymorphonuclear leukocytes. By day 3, the leukocytes disappeared, and this event was followed by migration and close apposition of fibroblast cell surface to the collagenous matrix. This initial matrix-membrane interaction culminated in differentiation of fibroblasts to chondroblasts and osteoblasts. The calcification of the hypertrophied chondrocytes and new bone formation were correlated with increased alkaline phosphatase activity and 4sCa incorporation. The ingrowth of capillaries on day 9 resulted in chondrolysis and osteogenesis. Further remodelling of bony trabeculae by osteoclasts resulted in an ossicle of cancellous bone. This was followed by emergence of extravascular islands of hemocytoblasts and their differentiation into functional bone marrow with erythropoietic and granulopoietic elements and megakaryocytes in the ossicle. The onset and maintenance of erythropoiesis in the induced bone marrow were monitored by 5'Fe incorporation into protein-bound heme. These findings imply a role for extracellular collagenous matrix in cell differentiation.There is growing knowledge about the intracellular molecules involved in cell differentiation (8). However, information pertaining to the possible role of extracellular matrix macromolecules such as collagen and proteoglycans has lagged (20). A characteristic feature of multicellular metazoa is the presence of extracellular matrix. In skeletal and dental tissues, extracellular matrices are most prominent and may provide important clues to their role.On contact with demineralized collagenous matrices of bone and tooth, responding fibroblasts (mesenchymal cells) show an alteration of gene expression which results in emergence of new phenotypes (18,19,22,32,33). Simple techniques to study this phenomenon were developed and the temporal sequence of events were delineated (22).

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“…In a previous paper [Martland and Robison, 1924] certain possible sources of error in the estimation of P by the Briggs method were pointed out and it may be of use to describe the exact procedure now employed after 2 years' further experience. It should be added that the slight modifications introduced involve no radical change in this very useful method.…”

Section: Methodmentioning

confidence: 99%