The phenotype of migraine with unilateral cranial autonomic symptoms documents increased peripheral and central trigeminal sensitization. A case series of 757 patients

Barbanti, Piero; Aurilia, Cinzia; Dall’Armi, Valentina; Egeo, Gabriella; Fofi, Luisa; Bonassi, Stefano

doi:10.1177/0333102416630579

Cited by 70 publications

(86 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hypothalamus, whose activation is itself a possible trigger of CH attacks, is also a generator of accompanying symptoms of a “migrainous” type and, through its descending projections, might activate the spinal trigeminal nuclei and the region of the dorsal rostral pons, which are believed to be specifically activated in migraine attacks . An intense activation of the trigeminal system through the trigeminal‐autonomic reflexes might also explain the great variety of CAS in patients with MLF …”

Section: Discussionmentioning

confidence: 99%

“…16 An intense activation of the trigeminal system through the trigeminal-autonomic reflexes might also explain the great variety of CAS in patients with MLF. 17 Considering the high prevalence of migraine in the general population, 8 it is likely that its "biology" is prevalent as well. By that we mean a particular "brain state" resulting from functional alterations in the hypothalamic and brainstem circuits.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cluster Headache With Accompanying Migraine‐Like Features: A Possible Clinical Phenotype

et al. 2016

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cluster Headache With Accompanying Migraine‐Like Features: A Possible Clinical Phenotype

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Considerable proportions of cultured trigeminal ganglion neurons responding to carbachol and nicotine with calcium transients were found suggesting that both nAchR and mAchR are functional (Shelukhina et al 2017). This may be important for the idea that parasympathetic nerve fibers signal to trigeminal afferents possibly promoting trigeminal autonomic cephalalgias and migraine characterized by autonomic symptoms (Goadsby 2005;Barbanti et al 2016).…”

Section: Receptors For Other Signal Molecules Expressed In the Trigemmentioning

confidence: 99%

Cross-talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators

2020

View full text Add to dashboard Cite

The trigeminal ganglion with its three trigeminal nerve tracts consists mainly of clusters of sensory neurons with their peripheral and central processes. Most neurons are surrounded by satellite glial cells and the axons are wrapped by myelinating and non-myelinating Schwann cells. Trigeminal neurons express various neuropeptides, most notably, calcitonin generelated peptide (CGRP), substance P, and pituitary adenylate cyclase-activating polypeptide (PACAP). Two types of CGRP receptors are expressed in neurons and satellite glia. A variety of other signal molecules like ATP, nitric oxide, cytokines, and neurotrophic factors are released from trigeminal ganglion neurons and signal to neighboring neurons or satellite glial cells, which can signal back to neurons with same or other mediators. This potential cross-talk of signals involves intracellular mechanisms, including gene expression, that can modulate mediators of sensory information, such as neuropeptides, receptors, and neurotrophic factors. From the ganglia cell bodies, which are outside the blood-brain barrier, the mediators are further distributed to peripheral sites and/or to the spinal trigeminal nucleus in the brainstem, where they can affect neural transmission. A major question is how the sensory neurons in the trigeminal ganglion differ from those in the dorsal root ganglion. Despite their functional overlap, there are distinct differences in their ontogeny, gene expression, signaling pathways, and responses to anti-migraine drugs. Consequently, drugs that modulate cross-talk in the trigeminal ganglion can modulate both peripheral and central sensitization, which may potentially be distinct from sensitization mediated in the dorsal root ganglion.

show abstract

“…Several endophenotypes have been proposed in migraine, including prodromal symptoms such as yawning, aura, or accompanying symptoms like nausea, vomiting and pulsating. Unilateral autonomic symptoms during attacks are also raised as endophenotypes of migraine [13]. The association of some endophenotypes and migraine implicit genotypes have been studied and reported [14,15].…”

Section: Introductionmentioning

confidence: 99%

TRPM8 genetic variant is associated with chronic migraine and allodynia

et al. 2019

View full text Add to dashboard Cite

Background: Many single nucleotide polymorphisms (SNPs) have been reported to be associated with migraine susceptibility. However, evidences for their associations with migraine endophenotypes or subtypes are scarce. We aimed to investigate the associations of pre-identified migraine susceptibility loci in Taiwanese with migraine endophenotypes or subtypes, including chronic migraine and allodynia. Methods: The associations of six SNPs identified from our previous study, including TRPM8 rs10166942, LRP1 rs1172113, DLG2 rs655484, GFRA1 rs3781545, UPP2 rs7565931, and GPR39 rs10803531, and migraine endophenotypes, including chronic migraine and allodynia were tested. Significant associations in the discovery cohort were validated in the replication cohort. The adjusted odds ratios (aOR) were calculated after controlling for confounders.Results: In total, 1904 patients (mean age 37.5 ± 12.2 years old, female ratio: 77.7%) including 1077 in the discovery cohort and 827 in the replication cohort were recruited. Of them, 584 (30.7%) had chronic migraine. Of the 6 investigated SNPs, TRPM8 rs10166942 T allele-carrying patients were more likely to have chronic migraine than non-T allele carriers in both discovery and replication cohorts and combined samples (33.7% vs. 25.8%, p = 0.004, aOR = 1.62). In addition, T allele carriers reported more allodynic symptoms than non-T allele carriers (3.5 ± 3.7 vs. 2.6 ± 2.8, p < 0.001). However, allodynia severity did not differ between episodic and chronic migraine patients. No further correlations between genetic variants and endophenotypes were noted for the other SNPs. Conclusions: TRPM8 may contribute to the pathogenesis of chronic migraine. However, our study did not support allodynia as a link between them. The underlying mechanisms deserve further investigations.

show abstract

The phenotype of migraine with unilateral cranial autonomic symptoms documents increased peripheral and central trigeminal sensitization. A case series of 757 patients

Cited by 70 publications

References 38 publications

Cluster Headache With Accompanying Migraine‐Like Features: A Possible Clinical Phenotype

Cluster Headache With Accompanying Migraine‐Like Features: A Possible Clinical Phenotype

Cross-talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators

TRPM8 genetic variant is associated with chronic migraine and allodynia

Contact Info

Product

Resources

About