The Phenomenon of “Subjective Age” as an Epigenetic Cellular-Molecular Mechanism

Torday, John S.

doi:10.1007/978-3-030-93691-4_1

Cited by 1 publication

(1 citation statement)

References 48 publications

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“…Interestingly, stronger epigenetic age acceleration was associated with a narrower subjective health horizon, consistently at baseline and follow-up seven years later. It has been argued that an individual's sense of aging can be shaped by aggregate cellular stress 34 . Individuals who have undergone challenging life experiences may perceive themselves as prematurely aged due to the cumulative impact of subclinical deterioration and allostatic load.…”

Section: Discussionmentioning

confidence: 99%

There are multiple clocks that time us: Cross-sectional and longitudinal associations among 14 alternative indicators of age and aging

Drewelies,

Homann,

Vetter

et al. 2023

Preprint

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Aging is a complex process influenced by mechanisms operating at numerous levels of functioning. Multiple biomarkers of age have been identified, yet we know little about how the different alternative age indicators are intertwined. In the Berlin Aging Study II, we examined how levels and seven-year changes in indicators derived from blood assays, MRI brain scans, other-ratings, and self-reports converge among older adults. Weincluded eight epigenetic biomarkers (incl. five epigenetic “clocks”), a BioAge composite from clinical laboratory parameters, brain age, skin age, subjective age, subjective life expectancy, and future health horizon. We found moderate associations within aging domains, both cross-sectionally and longitudinally. However, associations across different domains were infrequent and modest. Notably, participants with older BioAge had correspondingly older epigenetic ages. Our results suggest that different aging clocks are only loosely interconnected and that more specific measures are needed to differentiate healthy from unhealthy aging.

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Section: Discussionmentioning

confidence: 99%