The phenolic components extracted from mulberry fruits as bioactive compounds against cancer: A review

Abstract

In Asia, mulberry has long been used to treat various infectious and internal ailments as a traditional medication. The compounds found in it have the potential to improve human health. Because there is no approved and defined evaluation procedure, it has not been formally or scientifically recognized. As a result of these investigations, a new frontier in traditional Chinese medicine has opened up, with the possibility of modernization, for the interaction between active components of mulberry and their biological activities. These studies have used current biotechnological technologies. For ages, mulberry has been used as an herbal remedy in Asia to cure various diseases and internal disorders. It has a high concentration of bioactive chemicals that benefit human health. The most abundant phenolic components extracted from white mulberry leaves are flavonoids (Kuwanons, Moracinflavans, Moragrols, and Morkotins), phenolic acids, alkaloids, and so forth. Flavonoids, benzofurans, chalcones, and alkaloids have been discovered to have cytotoxic effects on human cancer cell lines. There is growing evidence that mulberry fruits can potentially prevent cancer and other aging‐related disorders due to their high concentration of bioactive polyphenolic‐rich compounds and macro and micronutrients. Anthocyanins are rapidly absorbed after eating, arriving in the plasmalemma within 15–50 min and entirely removed after 6–8 hr. Due to a lack of an approved and consistent technique for its examination, it has yet to be formally or scientifically recognized. The mulberry plant is commercially grown for silkworm rearing, and less attention is paid to its bioactive molecules, which have a lot of applications in human health. This review paper discusses the phenolic compounds of white mulberry and black mulberry in detail concerning their role in cancer prevention.

Mulberry leaf extract and neochlorogenic acid ameliorate glucolipotoxicity-induced diabetic nephropathy in high-fat diet-fed db/db mice

“…A review study revealed that MLE contains various bioactive compounds, including alkaloids, flavonoids, and phenolic acids. 31 Mulberry leaves have strong antioxidant properties and offer several health benefits, including regulation of sugar metabolism, improvement of lipid balance, reduction of oxidative stress, enhancement of mitochondrial function, and protection against diabetes. 10 Additionally, MLE reduces the blood glucose level of individuals with diabetes.…”

Exploring the Power of Thermosonication: A Comprehensive Review of Its Applications and Impact in the Food Industry

“…Figure 2 illustrates a diagram that explains the reasons why ultrasound extraction is considered a technology with great potential. Bioactive compounds are naturally occurring substances in food that can have positive health effects when consumed [ 98 ]. Antioxidants, polyphenols, carotenoids, and flavonoids are some instances of bioactive compounds.…”

The Impact of White Mulberry, Green Barley, Chia Seeds, and Spirulina on Physicochemical Characteristics, Texture, and Sensory Quality of Processed Cheeses

“…In recent years, there has been a trend toward the use of plants as sources of various biologically active substances, exerting antioxidant and anti-inflammatory (for example, phenols, anthocyanins, non-anthocyanin flavonoids), anti-carcinogenic (for example, alkaloids, anthocyanins), and anti-diabetic effects [10][11][12]. However, the comprehensive use of a variety of nutrient-rich plants, especially those with fewer culinary and medicinal applications, is still rare, especially in the context of using them as additives in traditional foods.…”

“…Mulberry (Morus alba L.) fruits are most popular in East Asian countries such as Korea, China, Japan and Thailand, but are also consumed worldwide [20]. Due to the presence of polyphenols (such as phenolic acids (up to ~30 mg/kg fw), flavanol derivatives (from 55.62 to 432.38 mg/kg fw), and anthocyanins (up to ~3000 mg/kg fw)), polysaccharides, alkaloids, flavonoids, essential amino acids, and vitamins, white mulberry fruits are well known for their health-promoting properties, including anticoagulant, antioxidant, anti-diabetic, anti-obesity, anti-inflammatory, anti-carcinogenic, prokinetic, and neuroprotective effects [12,[19][20][21][22][23].…”