The phenolic acids of Agen prunes (dried plums) or Agen prune juice concentrates do not account for the protective action on bone in a rat model of postmenopausal osteoporosis

Léotoing, Laurent; Wauquier, Fabien; Davicco, Marie-Jeanne; Lebecque, Patrice; Gaudout, David; Rey, Stéphane; Vitrac, Xavier; Massenat, Laurent; Rashidi, Salim; Wittrant, Yohann; Coxam, Véronique

doi:10.1016/j.nutres.2015.10.002

Cited by 14 publications

(13 citation statements)

References 49 publications

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“…In the human body, polyphenols are antioxidants, and have diverse biological properties such as anti-diabetic [7,8], anticancer [9,10], anti-inflammatory [11,12], cardioprotective [13], osteoprotective [14,15], neuroprotective [16,17], antiasthmatic [18], antihypertensive [19], antiageing [20], antiseptic [21], cerebrovascular protection [22], cholesterol lowering [23], hepatoprotective [24], antifungal [25], antibacterial [26] and antiviral properties [27] (Figure 1). …”

Section: Polyphenolsmentioning

confidence: 99%

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

2017

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Polyphenols are plant secondary metabolites containing antioxidant properties, which help to protect chronic diseases from free radical damage. Dietary polyphenols are the subject of enhancing scientific interest due to their possible beneficial effects on human health. In the last two decades, there has been more interest in the potential health benefits of dietary polyphenols as antioxidant. Black soybeans (Glycine max L. Merr) are merely a black variety of soybean containing a variety of phytochemicals. These phytochemicals in black soybean (BSB) are potentially effective in human health, including cancer, diabetes, cardiovascular diseases, cerebrovascular diseases, and neurodegenerative diseases. Taking into account exploratory study, the present review aims to provide up-to-date data on health benefit of BSB, which helps to explore their therapeutic values for future clinical settings. All data of in vitro and in vivo studies of BSB and its impact on human health were collected from a library database and electronic search (Science Direct, PubMed, and Google Scholar). The different pharmacological information was gathered and orchestrated in a suitable spot on the paper.

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Section: Polyphenolsmentioning

confidence: 99%

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

2017

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“…The literature search of the PubMed database yielded 50 articles [10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61]. After title/abstract review, 22 articles were screened in full-text and included in this comprehensive review [10,11,12,13,14,15,16,17,18,19,20,21,22,23,…”

Section: Resultsmentioning

confidence: 99%

“…After title/abstract review, 22 articles were screened in full-text and included in this comprehensive review [10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,31,32]. Two additional studies [30,33] were included after examination of the reference lists of the 22 studies identified in the literature search.…”

Section: Resultsmentioning

confidence: 99%

“…Most the studies retrieved for full-text review were animal studies involving either rats or mice (16 total) [15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30], although three (cell) studies were also identified [31,32,33]. No observational studies were identified in the PubMed literature search or after examination of the reference lists of included studies.…”

Section: Resultsmentioning

confidence: 99%

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Dried Plums, Prunes and Bone Health: A Comprehensive Review

Wallace

2017

Nutrients

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The 2015–2020 Dietary Guidelines for Americans advocate for increasing fruit intake and replacing energy-dense foods with those that are nutrient-dense. Nutrition across the lifespan is pivotal for the healthy development and maintenance of bone. The National Osteoporosis Foundation estimates that over half of Americans age 50+ have either osteoporosis or low bone mass. Dried plums, also commonly referred to as prunes, have a unique nutrient and dietary bioactive profile and are suggested to exert beneficial effects on bone. To further elucidate and summarize the potential mechanisms and effects of dried plums on bone health, a comprehensive review of the scientific literature was conducted. The PubMed database was searched through 24 January 2017 for all cell, animal, population and clinical studies that examined the effects of dried plums and/or extracts of the former on markers of bone health. Twenty-four studies were included in the review and summarized in table form. The beneficial effects of dried plums on bone health may be in part due to the variety of phenolics present in the fruit. Animal and cell studies suggest that dried plums and/or their extracts enhance bone formation and inhibit bone resorption through their actions on cell signaling pathways that influence osteoblast and osteoclast differentiation. These studies are consistent with clinical studies that show that dried plums may exert beneficial effects on bone mineral density (BMD). Long-term prospective cohort studies using fractures and BMD as primary endpoints are needed to confirm the effects of smaller clinical, animal and mechanistic studies. Clinical and prospective cohort studies in men are also needed, since they represent roughly 29% of fractures, and likewise, diverse race and ethnic groups. No adverse effects were noted among any of the studies included in this comprehensive review. While the data are not completely consistent, this review suggests that postmenopausal women may safely consume dried plums as part of their fruit intake recommendations given their potential to have protective effects on bone loss.

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“…For instance, Zhou et al [60] demonstrated that supplementing Ovx rats with chlorogenic acid led to improved BMD and microarchitecture, and an increased proliferation of osteoblast precursors and osteoblast differentiation, as well as increases in bone formation biomarkers. Despite this, Léotoing et al [40] demonstrated that the bone-protective effects of dried plum is not dependent on the content of chlorogenic acids. As the authors pointed out, it is important to consider that dried plum contains other (poly)phenols such as quercetin, rutin, proanthocyanidins, among others, as well as dietary fiber in the form of soluble and insoluble fiber including pectin, fructans, hemicelluloses, and cellulose [23,40], which may be responsible for the effects of dried plum on bone.…”

Section: Bioactive Compounds and Possible Mechanisms Of Actionmentioning

confidence: 99%

Bone-Protective Effects of Dried Plum in Postmenopausal Women: Efficacy and Possible Mechanisms

et al. 2017

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Osteoporosis is an age-related chronic disease characterized by a loss of bone mass and quality, and is associated with an increased risk of fragility fractures. Postmenopausal women are at the greatest risk of developing osteoporosis due to the cessation in ovarian hormone production, which causes accelerated bone loss. As the demographic shifts to a more aged population, a growing number of postmenopausal women will be afflicted with osteoporosis. Certain lifestyle factors, including nutrition and exercise, are known to reduce the risk of developing osteoporosis and therefore play an important role in bone health. In terms of nutrition, accumulating evidence suggests that dried plum (Prunus domestica L.) is potentially an efficacious intervention for preventing and reversing bone mass and structural loss in an ovariectomized rat model of osteoporosis, as well as in osteopenic postmenopausal women. Here, we provide evidence supporting the efficacy of dried plum in preventing and reversing bone loss associated with ovarian hormone deficiency in rodent models and in humans. We end with the results of a recent follow-up study demonstrating that postmenopausal women who previously consumed 100 g dried plum per day during our one-year clinical trial conducted five years earlier retained bone mineral density to a greater extent than those receiving a comparative control. Additionally, we highlight the possible mechanisms of action by which bioactive compounds in dried plum exert bone-protective effects. Overall, the findings of our studies and others strongly suggest that dried plum in its whole form is a promising and efficacious functional food therapy for preventing bone loss in postmenopausal women, with the potential for long-lasting bone-protective effects.

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The phenolic acids of Agen prunes (dried plums) or Agen prune juice concentrates do not account for the protective action on bone in a rat model of postmenopausal osteoporosis

Cited by 14 publications

References 49 publications

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

Dried Plums, Prunes and Bone Health: A Comprehensive Review

Bone-Protective Effects of Dried Plum in Postmenopausal Women: Efficacy and Possible Mechanisms

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