The Phases of Foreign Protein Sensitization in Human Beings

Jones, T. Duckett; Mote, John R.

doi:10.1056/nejm193401182100302

Cited by 122 publications

(36 citation statements)

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“…Of interest is that in the human, as originally described by Jones and Mote (15), delayed hypersensitivity precedes wheal-and-flare antibody responses and reappears as the latter wanes; similar observations have been made in the guinea pig by Sell and Weigle (16). Of relevance also may be the report that delayed skin reactions may be "unmasked" if the wheal-andflare skin reaction is inhibited by antihistamines in grass pollen-sensitive patients (17).…”

supporting

confidence: 57%

Cutaneous Basophil (Jones-Mote) Hypersensitivity After "Tolerogenic" Doses of Intravenous Ovalbumin in the Guinea Pig

Richerson

1971

The Journal of Experimental Medicine

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Cutaneous basophil hypersensitivity (CBH) was studied for tolerogenic requirements. Graded doses of intravenous ovalbumin (OA) were given to guinea pigs which were subsequently immunized appropriately to produce CBH, classic delayed hypersensitivity (classic DH), and/or antibodies of both passive cutaneous anaphylaxis (PCA) and hemolytic types. Results showed that doses of intravenous antigen sufficient to induce subsequent tolerance for classic DH and hemolytic antibody actually stimulate CBH reactivity and PCA antibody production. Other studies of dose-route relationships for CBH production demonstrated that optimal immunogenic dosage requirements for CBH varied widely with route of antigen employed. OA in incomplete Freund's adjuvant (IFA) injected into footpads had low dosage requirements, intravenous OA had high dose requirements, and intradermal soluble OA dosage requirements were intermediate. The observation that blatant immunogenic responses occur during the early period of tolerance induction amplifies the significant heterogeneity of the cellular immune response and may be of importance in understanding tolerogenesis. Similar immunogenic-tolerogenic requirements and the prime role played by the basophil suggest a developmental or functional relationship between CBH and PCA antibody response.

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confidence: 57%

Cutaneous Basophil (Jones-Mote) Hypersensitivity After "Tolerogenic" Doses of Intravenous Ovalbumin in the Guinea Pig

Richerson

1971

The Journal of Experimental Medicine

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“…Jones-Mote hypersensitivity can be elicited only at an early period of such immunization and becomes undetectable with the prominent appearance of serum antibodies. Thus, identification of this type of delayed reaction as a distinct entity has been difficult for a long time since the first report on human subjects by Jones and Mote (9), and many investigators have regarded Jones-Mote reactivity as a weak expression of delayed hypersensitivity. Recently, Dvorak and his coworkers demonstrated that extensive infiltration of basophils at the reaction sites was the most discriminative feature of Jones-Mote reactions (5).…”

Section: Discussionmentioning

confidence: 99%

Relation between Delayed Skin Reactivity and Macrophage Migration Inhibition or Lymphocyte Transformation in Tuberculin‐Type Hypersensitivity and Jones‐Mote Hypersensitivity

Himeno

Nomoto

Kuroiwa

et al. 1977

Microbiology and Immunology

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Precise time-course studies on delayed skin reaction, lymphocyte transformation and macrophage migration inhibition were carried out from day 3 to 270 and from day 3 to 120, respectively, in guinea pigs immunized with bovine gamma-globulin (BGG) in complete Freund's adjuvant (CFA) and those immunized with BGG in incomplete Freund's adjuvant (IFA). a) Delayed skin reactions could be elicited for a long period of time after immunization with BGG in CFA in the presence of prominent antibody production and were accompanied by induration. b) Delayed reactions could be elicited transiently after immunization with BGG in IFA and were not accompanied by induration. c) At the peak of hypersensitivity, infiltrating cells at the reaction sites were composed largely of mononuclear cells and basophils, respectively, in the animals immunized with BGG in CFA and those immunized with BGG in IFA. d) Uptake of 3H-thymidine by lymphocytes was increased remarkably in the presence of BGG when cells were obtained at early stages after immunization by both methods. e) Macrophage migration inhibition was strongly positive in animals immunized with BGG in CFA but weakly positive in those immunized with BGG in IFA. Increased lymphocyte transformation preceded the appearance of a positive migration inhibition. f) After immunization with BGG in CFA, Jones-Mote hypersensitivity appeared to precede the development of tuberculin-type hypersensitivity.Delayed hypersensitivity includes several distinctive phenomena of which the common feature is a delayed onset of skin reactions after administration of the eliciting antigens. Classical delayed hypersensitivity of tuberculin-type, Jones-Mote hypersensitivity and contact sensitivity have been assigned to this category. However, mutual relationships among individual reactions and essential characteristics of each reaction have not yet been identified definitely. Lymphocyte blastoid trans-The results in this paper were reported at

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“…Duckett Jones and John R. Mote described in 1934 the development of skin reactivity in humans after repeated intradermal injections of small amounts of rabbit serum proteins (7). A 24 hr "tuberculin type" skin reaction eventually developed in the usual subject, followed after additional testing by an immediate wheal and flare reaction and waning of the delayed component.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Basophil Hypersensitivity

Richerson

Dvorak

Leskowitz

1970

The Journal of Experimental Medicine

103

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Delayed (cell-mediated) hypersensitivity reactions have been regarded by most workers as a qualitatively homogeneous group (1-3), although well-recognized quantitative differences occur depending primarily on mode of immunization. Classic tuberculin-type delayed hypersensitivity is typically produced by the injection of antigen in complete Freund's adjuvant or in other mixtures containing products of the tubercle bacillus; similar reactivity occurs after dermal contact with simple chemicals and after infections (mycobacterial, fungal, and viral). Delayed-onset skin reactivity can also be produced transiently in a variety of soluble proteins by injection of antigen-antibody complexes or small amounts of the antigen intradermally without mycobacterial adjuvant (4, 5). The latter type of delayed hypersensitivity was termed "Jones-Mote" reactivity by Raffel and Newel (6), who considered it to be qualitatively different from classic delayed hypersensitivity and resembling more closely reactions seen, by those investigators, in humans (7). In the guinea pig, both types of delayed hypersensitivity give a maximum skin reaction at 24 hr, are not necessarily associated with circulating antibody, and can be passively transferred by cells but not by serum (5). Jones-Mote reactivity occurs early in immunization and is evanescent, waning with the appearance of circulating antibody, in contrast to classic delayed hypersensitivity which persists and increases with time. Histologic studies in the past (8-10) have in general shown only quantitative differences between classic delayed and J ones-Mote hypersensitivity reactions, and most investigators have felt the latter to be a weak form of the delayed reaction.The question of whether the two types of delayed-onset hypersensitivity involve similar or qualitatively different mechanisms was studied using the

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The Phases of Foreign Protein Sensitization in Human Beings

Cited by 122 publications

References 0 publications

Cutaneous Basophil (Jones-Mote) Hypersensitivity After "Tolerogenic" Doses of Intravenous Ovalbumin in the Guinea Pig

Cutaneous Basophil (Jones-Mote) Hypersensitivity After "Tolerogenic" Doses of Intravenous Ovalbumin in the Guinea Pig

Relation between Delayed Skin Reactivity and Macrophage Migration Inhibition or Lymphocyte Transformation in Tuberculin‐Type Hypersensitivity and Jones‐Mote Hypersensitivity

Cutaneous Basophil Hypersensitivity

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