The phase angle as a predictor of postoperative complications in patients undergoing lung cancer surgery

Suzuki, Yamato; Kushimoto, Yuki; Ishizawa, Hisato; Kuroda, Hiroshi; Ito, Akihiro; Matsuda, Yasushi; Hoshikawa, Yasushi

doi:10.1007/s00595-022-02564-x

Cited by 5 publications

(9 citation statements)

References 24 publications

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“…This systematic review includes several types of studies: five prospective studies [ 35 – 39 ], three observational studies [ 40 – 42 ], two retrospective studies [ 34 , 43 ] and one cross-sectional study [ 44 ]. Shi et al showed the highest number of patients involved (804).…”

Section: Resultsmentioning

confidence: 99%

“…Shi et al included adenocarcinoma, squamous cell carcinoma, SCLC and other type of LC patients in different stage of disease (from I to IV) [ 39 ]. Suzuki et al and Hui et al showed data on LC patients but did not specify cancer type or stage [ 43 , 45 ]. Cancer stage was not specified in two studies [ 36 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

“…Three studies included patients not undergoing CHT, RT and without specific treatment information [ 37 , 39 , 45 ] while newly diagnosed patients and/or patients with ongoing therapies were evaluated in remaining studies [ 34 , 36 , 38 , 42 ]. Suzuki et al [ 43 ] evaluated LC patients after surgery while patients were evaluated after cancer treatment in two studies [ 40 , 41 ]. Castanho et al [ 44 ] evaluated patients after surgery and after cancer treatment (CHT, RT).…”

Section: Resultsmentioning

confidence: 99%

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Bioelectrical impedance analysis—derived phase angle (PhA) in lung cancer patients: a systematic review

Prete,

Ballarin,

Porciello

et al. 2024

BMC Cancer

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Background Lung cancer is the second most diagnosed cancer in the world. Up to 84% of diagnosed patients have malnutrition, which can negatively affect quality of life and survival and may worsen with neoadjuvant treatment. Bioelectrical Impedance Analysis-Derived Phase Angle (PhA) in these patients could be a valid tool to assess the nutritional status in order to improve their condition. Methods This review provides an update on PhA assessment in lung cancer patients over the past twenty years. We searched PubMed, Embase, Scopus, Web of Science, and Cochrane, for articles regarding the PhA obtained from Bioelectrical Impedance Analysis in lung cancer patients. The authors independently performed a literature search: sample size, patient population, study type, study dates, survival and interventions were evaluated. The final review included 11 studies from different countries. Results Eight studies only considered patients with lung cancer, while three studies considered patients with different kind of cancer, including lung. Correlation data between PhA and age are conflicting. In patients undergoing clinical treatment and patients undergoing surgical treatment lower PhA was observed. A lower PhA is associated with a shorter survival. In three studies emerged a relationship between Karnofski Performance Status and Handgrip Strenght with PhA. From one study, univariate logistic regression analysis showed that higher PhA values represent a protective factor for sarcopenia. Conclusion Our research underlined interesting, but not conclusive, results on this topic; however more researches are needed to understand the clinical meaning of PhA.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Bioelectrical impedance analysis—derived phase angle (PhA) in lung cancer patients: a systematic review

Prete,

Ballarin,

Porciello

et al. 2024

BMC Cancer

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“…The pooled consequences of COVID-19 and cancer picture the importance of constant monitoring of some prognostic-related variables, such as body composition 7 , anthropometric, cardiovascular risk indices 8,9 , dynapenia and sarcopenia 10,11 as well as phase angle. These variables are non-invasive with simple application in the clinical practice, for example, bioimpedance phase angle (FA) might indicates cellular health and is widely used as a health status to predict different disease severity and survival in different medical conditions, particularly cancer 12 . Therefore, a better characterization of these variables can improve the scienti c and clinical knowledge on the prognosis of cancer patients during the COVID-…”

Section: Introductionmentioning

confidence: 99%

Chemotherapy and COVID-19: Impact on Health, Strength, and Cardiovascular Risk in Cancer Patients

Lima,

Silva

et al. 2023

Preprint

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Objective: To evaluate and describe the phase angle profile and anthropometric health and fitness indicators of patients undergoing chemotherapy. Materials and Method: The sample included 106 adult and elderly cancer patients, with different types of cancer, undergoing chemotherapy treatment, of both sexes (71 women and 35 men). They underwent anthropometric assessment, tetrapolar bioimpedance, anthropometry, handgrip dynamometry and the international physical activity questionnaire (IPAQ). Results: After the analysis, the Body Mass Index (BMI) showed that 49% had changes in ideal body mass indices (13% below and 36% above ideal). The waist-to-hip ratio of most patients (63.7%) indicated a high (36.4%) and very high (27.3%) risk of developing cardiovascular diseases, with only 27.3% being moderate and 9.1% Low %, with higher risk values in women. In body composition, 62.9% of patients showed important changes in body fat percentage (22.9% below and 35% above recommended), in addition to the high prevalence of reduction in skeletal muscle mass, reaching 76% of those evaluated, indicating possible development of sarcopenia, being more evident in women. The majority of patients also had inadequate strength levels (63.6%), both men and women. Men are approximately 4 times more likely to have an insufficient level of strength. The phase angle with an average below the recommended level was found in 94.8% of the sample. The level of physical activity assessed demonstrated 100% sedentary lifestyle. Conclusion: With the investigation of the variables proposed in this study, we concluded that patients undergoing chemotherapy during the COVID-19 pandemic period had an insufficient level of physical activity, an inadequate level of muscle strength, anthropometric indices and body composition with negative changes, increased cardiovascular risk and low phase angle of reference values in the majority of the sample, with women having the most unfavorable profile. The research project was approved by the institutional review board, no. 5.069.269.

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“…Bioelectrical Phase Angle (PhA) is a specific biomarker which is derived from BIVA measurements of R and Xc using a 50 kHz phase-sensitive bioimpedance instrument [11]. Studies outlined the impact of PhA in the general assessment of healthy and unhealthy individuals, allowing the depiction of information about the clinical conditions of muscle mass of patients, cancer evolution and impact of chemotherapies, or even prognostic implication during COVID-19 infection [12][13][14][15].…”

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confidence: 99%

The role of bioelectrical phase angle in patients with heart failure

Scicchitano¹,

Massari²

2022

Rev Endocr Metab Disord

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The most challenging feature of heart failure (HF) still remains the evaluation of congestion. Residual congestion at discharge and the difficulties in perfectly dosing therapies in order to balance the hydration status of the patient are the most worrisome issues when dealing with HF. The use of bioimpedance vector analysis (BIVA) might promote a different approach in the general management of patients with HF. BIVA is a reliable, fast, bedside tool able to assess the congestion status. It proved to be helpful to physicians for diagnosing congestive status, managing therapies, and providing prognostic information in the setting of HF. Bioelectrical Phase Angle (PhA) – as derived from equations related to the parameters of BIVA – recently surged as a possible biomarker for patients with HF. Studies provided data about the application of PhA in the clinical management and in the overall risk stratification of HF patients. Basically, the use of PhA might be considered as a holistic evaluation of patients with HF which includes the need for a multiparametric approach able to effectively depict the clinical status of patients. There is no definite biomarker able to comprehensively describe and identify all the features of HF patient, but scores based on molecules/techniques able to explore the different pathogenetic mechanisms of HF are desirable. The aim of this review was to provide a comprehensive evaluation of literature related to PhA role in HF and the impact of this biomarker on clinical management and risk stratification of HF patients.

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The phase angle as a predictor of postoperative complications in patients undergoing lung cancer surgery

Cited by 5 publications

References 24 publications

Bioelectrical impedance analysis—derived phase angle (PhA) in lung cancer patients: a systematic review

Bioelectrical impedance analysis—derived phase angle (PhA) in lung cancer patients: a systematic review

Chemotherapy and COVID-19: Impact on Health, Strength, and Cardiovascular Risk in Cancer Patients

The role of bioelectrical phase angle in patients with heart failure

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