“…However, we observed also a higher effectiveness of esomeprazole over pantoprazole in reducing AET, consistently with the findings of previous studies. 32,33 In particular, Miner et al 34 showed that esomeprazole (40 mg once daily), at the steady-state (day 5), achieved a higher per cent of time with intragastric pH higher than 4.0 over 24 h, when compared with standard-dose lansoprazole, omeprazole, pantoprazole or rabeprazole in patients with symptoms of GERD. Moreover, dose escalation with oral esomeprazole and pantoprazole (patients treated once-daily with either drug at 20, 40 and 80 mg, for 5 days) improved the acid control in patients with GERD, although esomeprazole allowed a significantly better control on a milligram-per-milligram basis.…”