The Pharmacology of Brietal Sodium (Methohexitone Sodium)

Whitwam, J. G.

doi:10.1007/978-3-642-46276-4_2

Cited by 5 publications

(3 citation statements)

References 65 publications

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“…In equipotent doses methohexitone causes less cardiovascular depression and is associated with more rapid recovery than thiopentone. The subject has been recently reviewed by Whitwam (1972), and the evidence currently available suggests that methohexitone is the induction agent of choice for caesarean section. One possible disadvantage in using BRITISH MEDICAL JOURNAL 1 JUNE 1974 methohexitone in preference to thiopentone is the risk of awareness during surgery.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Effect of Two Induction Doses of Methohexitone on Infants Delivered by Elective Caesarean Section

Holdcroft¹,

Robinson²,

Gordon³

et al. 1974

BMJ

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Section: Discussionmentioning

confidence: 99%

Comparison of Effect of Two Induction Doses of Methohexitone on Infants Delivered by Elective Caesarean Section

Holdcroft¹,

Robinson²,

Gordon³

et al. 1974

BMJ

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“…It is used mainly for induction rather than maintenance of anesthesia. Cumulative effects after repeated administrations of the drug are believed to be minimal (Whitwam, 1972;Wyler et al, 1987). The activating properties of methohexital on the epileptic focus were first described by Wilder (1969Wilder ( , 1971) and later confirmed by other investigators (Harris and Paul, 1969; Gumpert and Paul, 1971; Musella et al, 1971; Celesia and Paulsen, 1972;Hardiman et al, 1987).…”

mentioning

confidence: 93%

“…Cumulative effects after repeated administrations of the drug are believed to be minimal (Whitwam, 1972;Wyler et al, 1987). It is used mainly for induction rather than maintenance of anesthesia.…”

mentioning

confidence: 99%

Localization of the Epileptic Focus During Methohexital‐Induced Anesthesia

et al. 1992

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A short anesthesia was provided by methohexital for painless percutaneous removal of subdural electrodes in 27 patients with medically intractable, complex partial seizures who had undergone invasive preoperative evaluation. Electrocorticographic(ECoG) recordings performed before and during the narcosis were submitted to visual (n = 27) and computerized (n = 3) analysis to obtain additional information about the location of the epileptic focus (or foci). The following observations were made: focal epileptiform potentials were induced in 24 of 27 patients (89%); (b) in 20 of these 24, the induced spikes appeared amid or were followed by isoelectric or subdelta activity. These spikes were characterized by high amplitude as well as rhythmic and synchronized appearance over a circumscribed focal area (or areas) known to be spontaneously epileptogenic. This phenomenon, termed spike-burst-suppression (SBS) pattern, allowed identification of the primary epileptic focus in many patients with temporal lobe epilepsy. Furthermore, it indicated a good outcome of epilepsy surgery. Computerized analysis of the induced synchronized spikes (n = 3) allowed further delineation of the primary site of epileptogenicity and quantitative comparison of multiple epileptic generators. ECoG recording during deep methohexital-induced narcosis is a valuable tool for lateralization and delineation of the primary epileptogenic focus.

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Pharmacokinetics of Methohexitone Following Intravenous Infusion in Humans

Breimer

1976

British Journal of Anaesthesia

100

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A sensitive method, using gas chromatography with nitrogen selective detection, has been developed for the accurate measurement of methohexitone, in plasma, in concentrations of less than 0.05 mug/ml, and which makes it possible to study the pharmacokinetics of the drug after clinical doses in man. Methohexitone sodium 3.0 mg/kg was administered by zero-order infusion to healthy volunteers and plasma concentrations were measured during and after infusion. The decrease in the plasma concentration of methohexitone can be described by two-compartment kinetics. The terminal elimination half-life of the drug is relatively short (70-125 min), which is a result of a high metabolic clearance rate (657-999 ml plasma/min). It was concluded that uptake of the drug by adipose tissue does not contribute significantly to its pharmacokinetics in man. In addition to the initial redistribution of an anaesthetic dose of methohexitone, the quick recovery of patients is a result of rapid metabolism of the drug.

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The Pharmacology of Brietal Sodium (Methohexitone Sodium)

Cited by 5 publications

References 65 publications

Comparison of Effect of Two Induction Doses of Methohexitone on Infants Delivered by Elective Caesarean Section

Comparison of Effect of Two Induction Doses of Methohexitone on Infants Delivered by Elective Caesarean Section

Localization of the Epileptic Focus During Methohexital‐Induced Anesthesia

Pharmacokinetics of Methohexitone Following Intravenous Infusion in Humans

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