The pharmacology of apoptosis

Overview of cell death signaling pathways

“…178 Bcl-2 belongs to the family of proto-oncogenes, but the ability of bcl-2 to promote tumor growth is different from other oncogenes; it can rescue cells that are destined to die without affecting the proliferation rate of the cell. 179 It is possible that the location of Bcl-2 might be a key feature of its function. Bcl-2 is involved in maintaining homeostatsis, including the mitochondrial membrane status and balance of the interactions between the members of the Bcl-2 protein family (e.g., Bax).…”

Cytoprotective Effects of KIOM-79 on Streptozotocin Induced Cell Damage by Inhibiting ERK and AP-1

“…Western Blot Cells were placed in a culture dish at 1ϫ10 6 cells/dish and at 16 h after plating, the cells were treated with KIOM-79 at 50 mg/ml. The cells were harvested, and washed twice with PBS.…”

“…4,5) Medicinal plants are currently being investigated for their pharmacological properties in the regulation of blood glucose and apoptosis induced by oxidative stress, a process which is pivotal in the pathology of diabetes mellitus. 6,7) A combination of plant extracts (KIOM-79) was prepared from Magnolia officinalis, Pueraria lobata, Glycyrrhiza uralensis, and Euphorbia pekinensis. Magnolia officinalis reportedly has antimutagenic, 8) hepatocytic protective, 9,10) neuroprotective, 11) and anti-inflammatory effects.…”

Fatty acids, inhibitors for the DNA binding of c-Myc/Max dimer, suppress proliferation and induce apoptosis of differentiated HL-60 human leukemia cell

“…17 The inhibition of proliferation and induction of apoptosis are regulated by a network of signaling pathways and transcription factors, which are possible targets for a rational tumor therapy. 18,19 For instance, some anticancer reagents cause cell death through interfering with the processes of the cell cycle 20 and some others cause cell death by apoptosis, 21,22 which plays an important role in the balance between cell replication and cell death. Leukemia, one of the most threatening hematological malignant cancers, has been found to be very sensitive to anticancer reagents which either block the process of the cell cycle or cause apoptosis.…”