The pharmacological basis of contemporary pain management

MacPherson, Ross

doi:10.1016/s0163-7258(00)00090-5

Cited by 72 publications

(33 citation statements)

References 332 publications

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“…Currently, strong narcotic analgesic is given systemically or intrathecally to patients with chronic pain. Adjuvants or drug combinations were administered to alleviate the side effects of the analgesics (3). With the ability of antagonists to activate the mutant receptor, it is possible to engineer and deliver the mutant receptor molecules at the sites of pain control.…”

Section: Discussionmentioning

confidence: 99%

“…From studies on the neurobiology of pain (1) due to the myriad molecules and neurotransmitters that are involved in peripheral nociceptive processing and in the function of spinal nociceptive integration (2), pharmacological approaches for pain management have been based on the activating or inactivating receptors involved in neurotransmission (3). For example, within the dorsal horn of the spinal cord, several peptides such as substance P, somatostatin, neuropeptide Y, galanin, and calcitonin gene-related peptide; excitatory amino acids such as glutamate and aspartate; inhibitory amino acids such as ␥-aminobutyric acid; endogenous opioid peptides, adenosine, serotonin, norepinephrine, nitric oxide; and the arachidonic acid metabolites have all been implicated in the transmission and regulation of painful messages (4-6).…”

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confidence: 99%

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In vivo activation of a mutant μ-opioid receptor by antagonist: Future direction for opiate pain treatment paradigm that lacks undesirable side effects

Law

Yang

Guo

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

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CorrectionsFreshly elutriated human monocytes were allowed to interact with an anti-ICAM3-coated well, which leads to rapid PPAR␥ expression (13), and then stimulated, or not (negative, oxLDL), with oleoyl LPA. Some cells were then briefly exposed to oxidized LDL before intracellular lipid stores were visualized with oil red O stain. (b) LPA increases the expression of CD36 on the surface of primary human monocytes. Monocytes engaging anti-ICAM3 were treated or not with LPA, and then recovered by gentle scraping and washing by centrifugation before their surface CD36 was assessed by flow cytometry. (c) LPA and the LPA analogs XY4 and XY8 stimulate CD36 promoter function only when the PPRE is present. RAW264.7 cells were transfected with the human CD36 promoter containing the PPRE (CD36 Ϫ273 ) or a reporter that lacks only this element (CD36 Ϫ261 ) and then stimulated with oleoyl LPA, azPC, XY4, or XY8. Expression of luciferase normalized to ␤-galactosidase was determined as above. (d) Anti-CD36 blocks LPA-stimulated accumulation of cholesterol from oxidized LDL. Freshly isolated human monocytes were treated as in a, but after being preincubated with a blocking anti-CD36 antibody before exposure to oxidized LDL.www.pnas.org͞cgi͞doi͞10.1073͞pnas.0538065100 MEDICAL SCIENCES. For the article ''A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor,''

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

In vivo activation of a mutant μ-opioid receptor by antagonist: Future direction for opiate pain treatment paradigm that lacks undesirable side effects

Law

Yang

Guo

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

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“…O tratamento conservador consiste basicamente no alí-vio da dor e programas de terapia física para estabilização da musculatura abdominal e pélvica 6 . O tratamento cirúrgico envolve laminectomia com drenagem e cauterização da parede do cisto 11 ; esse procedimento pode provocar alteração neurológica. Uma outra alternativa cirúrgica é a drenagem percutânea que pode ser necessário repetir devido à recidiva dos cistos 11 .…”

Section: Discussionunclassified

“…O tratamento cirúrgico envolve laminectomia com drenagem e cauterização da parede do cisto 11 ; esse procedimento pode provocar alteração neurológica. Uma outra alternativa cirúrgica é a drenagem percutânea que pode ser necessário repetir devido à recidiva dos cistos 11 . Os riscos incluem infecção e cefaléia 6 .…”

Section: Discussionunclassified

“…Conservative treatment is basically pain relief and physical therapy to stabilize abdominal and pelvic muscles 6 . Surgical treatment involves laminectomy with cyst wall drainage and cauterization 11 , but this procedure may promote neurological changes. Another surgical alternative is percutaneous drainage, which might have to be repeated due to cysts recurrence 11 .…”

Section: Discussionmentioning

confidence: 99%

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