The pharmacological action of gastrin pentapeptide

Odori, Y.; Magee, D. F.

doi:10.1007/bf01899103

Cited by 4 publications

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“…How ever, the fact that non-mast cell histamine and rat gastric histidine decarboxylase are located near the base of the gastric glands, whereas the parietal cells are predominantly in the outermost half of the pits, makes it seem unlikely that histamine is the final common mediator of gastric secretion (31,36,81). The fact that hexamethonium is able to block gastric secretion stimulated by hista mine but not that evoked by pentagastrin in both the rat (40) and dog (112,114) also argues against such a theory. The recent demonstration that com- pounds (16) which block histamine H2 receptors also antagonise gastric secre tion, whatever secretagogue is used, has been adduced to favour histamine mediation.…”

Section: Implications Fo R the Mechanism O F Gastric Secretionmentioning

confidence: 89%

Amino Acid Decarboxylase Enzymes – Vital or Irrelevant to Gastric Secretion?

Henman¹

1975

Digestion

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The location and discovery of histidine decarboxylase and aromatic L-amino acid decarboxylase in the stomach are described. Feeding and gastrin-like agents stimulate increased gastric histidine decarboxylase (HD) activity in rats. Procedures which result in increased gastrin release – often by raising antral pH – also have this action in intact but not in antrectomised rats. Evidence for a histaminic feedback mechanism controlling HD levels is discussed. HD activity is reduced by protein synthesis inhibitors and by chronic pyridoxine deficiency. The effects of inhibitors of HD on gastric secretion in rat, dog and man are reviewed. The role of HD and histamine in gastric secretion is considered.

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Section: Implications Fo R the Mechanism O F Gastric Secretionmentioning

confidence: 89%

Amino Acid Decarboxylase Enzymes – Vital or Irrelevant to Gastric Secretion?

Henman¹

1975

Digestion

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The effect of hexamethonium on gastric acid secretion in the conscious rat

Bunce¹,

Parsons²

1977

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Evidence against a role for histamine in pentagastrin-stimulated acid secretion has been obtained previously using hexamethonium in gastric fistula rats. This possibility has been re-examined in conscious rats provided with gastric fistulae or Heidenhain pouches. Hexamethonium (20 mg/kg s.c.) inhibited basal acid secretion and acid secretion stimulated by histamine and pentagastrin in gastric fistula rats. The same dose of hexamethonium failed to produce a significant inhibition of acid secretion stimulated by bethanechol, pentagastrin or histamine in the presence of a low dose of bethanechol in Heidenhain pouch rats. These results provide no evidence to oppose the view that pentagastrin-stimulated acid secretion in the rat is mediated at least in part through the mobilization of gastric mucosal histamine. The inhibition of secretagogue induced acid secretion in the gastric fistula rat is mainly the result of a reduction in the basal acid output.

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The action of some agents active at autonomic ganglionic sites on the secretory response of the Heidenhain pouch to various stimuli

Odori

Magee

1969

European Journal of Pharmacology

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The pharmacological action of gastrin pentapeptide

Cited by 4 publications

References 0 publications

Amino Acid Decarboxylase Enzymes – Vital or Irrelevant to Gastric Secretion?

Amino Acid Decarboxylase Enzymes – Vital or Irrelevant to Gastric Secretion?

The effect of hexamethonium on gastric acid secretion in the conscious rat

The action of some agents active at autonomic ganglionic sites on the secretory response of the Heidenhain pouch to various stimuli

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