The pharmacokinetics of cefotetan excretion in the unobstructed biliary tree

Owen, Ambrose W.; Manson, J M; Yates, Roger; Adshead, V. M.; Houghton, H. L.; Tweedle, D. E. F.

doi:10.1093/jac/11.suppl_a.217

Cited by 13 publications

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“…Based on the observed mean CLR for group I and a reported protein binding of approximately 88% (16) in normal volunteers, cefotetan undergoes urinary excretion primarily by glomerular filtration but with some tubular secretion. The major route of nonrenal elimination probably is biliary excretion, because it has been shown that cefotetan rapidly appears in the bile in high concentrations after intravenous dosing in humans (12,14).…”

Section: Methodsmentioning

confidence: 99%

Cefotetan pharmacokinetics in volunteers with various degrees of renal function

Smith¹,

LeFrock²,

Thyrum³

et al. 1986

Antimicrob Agents Chemother

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Section: Methodsmentioning

confidence: 99%

Cefotetan pharmacokinetics in volunteers with various degrees of renal function

Smith¹,

LeFrock²,

Thyrum³

et al. 1986

Antimicrob Agents Chemother

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“…It is also excreted in the bile. Owen et al [70] studied the cefotetan excretion in patients who had undergone biliary or pancreatic surgery. Cefotetan was detected in bile taken from the common bile duct within 15 min of a 1-gram intravenous bolus.…”

Section: Less Commonly Used Cephalosporinsmentioning

confidence: 99%

Biliary Excretion of Antimicrobial Drugs

Karachalios

Charalabopoulos²

2002

Chemotherapy

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The development of drugs able to prevent and cure bacterial infections is one of the 20th century’s major contributions to human longevity and quality of life. Antibacterial agents are among the most commonly prescribed drugs of any kind worldwide. Used appropriately, these drugs are lifesaving. To eliminate an infection as rapidly as possible, a sufficient concentration of the drug(s) chosen must reach the site of infection. Serum/tissue concentration is a result of various parameters such as absorption, excretion, protein binding and metabolic inactivation. Biliary excretion is an important route for the elimination of some drugs and drug metabolites in humans. Thus, drugs with a high bile concentration are indicated for the treatment of gallbladder infectious diseases. We present a review of a large number of antimicrobial agents most commonly used in daily clinical practice, with regard to their biliary excretion.

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Absolute Bioavailability and Noncompartmental Analysis of Intravenous and Intramuscular Cefotan® (Cefotetan) in Normal Volunteers

Zimmerman

Cohen²,

Thyrum

1989

The Journal of Clinical Pharma

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Cefotetan (1 g) was administered to 12 normal volunteers as a 30 minute intravenous infusion and as an intramuscular injection. The pharmacokinetic parameters were estimated using noncompartmental analysis. The mean +/- SD maximum plasma concentration, terminal half-life, and systemic clearance after intravenous infusion were 158 +/- 21 micrograms/mL, 4.54 +/- 1.05 hours, and 29.1 +/- 3.8 mL/min/1.73 m2, respectively. Renal clearance and nonrenal clearance accounted for 63.1% and 36.9% of the systemic clearance, respectively. The mean +/- SD maximum plasma concentration, time to maximum concentration, terminal half-life, and absolute bioavailability after intramuscular injection were 75.5 +/- 8.7 micrograms/mL, 1.33 +/- 0.48 hours, 4.32 +/- 0.77 hours, and 0.931 +/- 0.193, respectively. Moment analysis gave average +/- SD mean residence times (MRT) of 4.98 +/- 0.75 and 5.86 +/- 0.77 hours after intravenous and intramuscular administration, respectively. The average +/- SD mean absorption time (MAT) after intramuscular injection was 1.11 +/- 0.57 hours. The mean +/- SD steady-state volume of distribution after intravenous infusion was 0.129 +/- 0.024 L/kg. The mean +/- SD cumulative percentage of the dose excreted in the urine in 24 hours were 61.1 +/- 11.4% and 50.4 +/- 13.5% after intravenous and intramuscular dosing, respectively. The maximum urinary cefotetan concentrations occurred during the first 2 hours after dosing by both routes of administration. Cefotetan tautomer was detected in the plasma and urine of all subjects after both routes of administration, but the mean concentrations were only minimal compared to those for cefotetan. In conclusion, intramuscular cefotetan (1 g) is rapidly and almost completely absorbed.(ABSTRACT TRUNCATED AT 250 WORDS)

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The pharmacokinetics of cefotetan excretion in the unobstructed biliary tree

Cited by 13 publications

References 0 publications

Cefotetan pharmacokinetics in volunteers with various degrees of renal function

Cefotetan pharmacokinetics in volunteers with various degrees of renal function

Biliary Excretion of Antimicrobial Drugs

Absolute Bioavailability and Noncompartmental Analysis of Intravenous and Intramuscular Cefotan® (Cefotetan) in Normal Volunteers

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