The Pharmacokinetics and Tolerability of an Intravenous Infusion of the New Hydroxyethyl Starch 130/0.4 (6%, 500 mL) in Mild-to-Severe Renal Impairment

Abstract

Dependency of the pharmacokinetics of hydroxyethyl starch 130/0.4 on renal function was studied. The area under the time concentration curve increased moderately with more severe renal dysfunction; however, small plasma concentrations were observed after 24 h. Terminal half-life and peak concentration remained unaffected by renal impairment.

RETRACTED ARTICLE: Influence of two different volume replacement regimens on renal function in elderly patients undergoing cardiac surgery: comparison of a new starch preparation with gelatin

“…Thus, the present study did not demonstrate that in patients with abnormal kidney function, volume replacement strategy using gelatin or HES 130/0.4 does not negatively affect renal function. However, in a study in volunteers with mild-to-moderate kidney dysfunction, infusion of 500 ml of HES 130/04 was not associated with a further deterioration in kidney function (e.g., unchanged creatinine clearance) [29].…”

Influence of low-molecular-weight hydroxyethyl starch on microvascular permeability in patients undergoing abdominal surgery: comparison with crystalloid

“…Some reports have shown that HES has no adverse infl uence on renal function in surgical patients [19,20], while other reports have shown that HES may impair renal function in surgical patients [21,22]. A recent review suggested that HES may have adverse effects on renal function, regardless of its molecular weight, DS, or C2/C6 ratio [23].…”

Colloid solutions: a clinical update

“…Furthermore, HES 130/0.4 did not negatively influence kidney integrity compared with a human albuminbased volume-replacement strategy in patients who had undergone cardiac surgery [97] or aortic aneurysm surgery [105] with preoperative compromised kidney function. In cases of severe renal dysfunction, a single bolus of 500 ml HES 130/0.4 did not impair creatinine clearance either [106]. Any hyper-oncotic colloid may have the potential to produce kidney dysfunction or renal failure because colloids may decrease glomerular filtration [13].…”