The Pharmacokinetics and Tolerability of an Intravenous Infusion of the New Hydroxyethyl Starch 130/0.4 (6%, 500 mL) in Mild-to-Severe Renal Impairment

RETRACTED ARTICLE: Le remplissage vasculaire avec de l’HEA 130/0,4 peut réduire la réaction inflammatoire chez des patients en chirurgie abdominale majeure

“…HES 130/0.4 has been reported to have pharmacokinetic and pharmacodynamic advantages such as decreased tissue storage, rapid plasma elimination and low impact on coagulation. 8,9 It was the goal of this prospective study to investigate the effects of intravascular volume replacement with HES 130/0.4 vs a colloid-free volume therapy on pro-and anti-inflammatory cytokines and soluble adhesion molecules in patients undergoing elective major abdominal surgery.…”

Phase II trial on the use of Dextran 70 or starch for supportive therapy in Kenyan children with severe malaria*

“…Nevertheless outcome in the pentastarch group was worse due to a higher number of dose-related episodes of renal failure (doubling of creatinine levels), requirement for renal replacement therapy and poorer survival over a 90 day follow up duration [27]. Whilst concerns for safety of starches is not new [28], recent evidence suggests that newer generation of medium molecular weight starches such as HES 130/0.4 do not increase the incidence of acute renal failure [29][30][31]. The higher concentration (10%) starches have a higher waterbinding capacity and hence reduced renal flow [32].…”

Renal Function In Off Pump Coronary Artery Bypass (Opcab) Surgeries: Effects Of Pentastarch And Tetrastarch: A Double Blind Randomised Trial

“…The plasma half life was prolonged by impaired renal function and was common in old age. 11 The mechanism of renal insult following colloid administration has been entitled as acute hyperoncotic renal failure syndrome and it has been attributed to the elevated colloid osmotic pressure, which offsets the hydrostatic glomerular function pressure, leading to reduced urine output. It is more with colloids having high molecular weight and high degree of substitution.…”