“…Pharmacokinetic studies carry out in different animal species and in human beings have showed that sucralose presents limited absorption, rapid urinary excretion, fecal excretion of unchanged sucralose, and minimal metabolism MEDICINAL CHEMISTRY RESEARCH of the absorbed material with no bioaccumulation John et al, 2000a;Roberts et al, 2000;Wood et al, 2000). Sucralose is not hydrolyzed in the intestinal lumen, poorly absorbed, and an elimination profile in humans similar to those found in the rat, rabbit, dog, and mouse John et al, 2000a, b;Wood et al, 2000).…”