The pharmacokinetics and metabolism of sucralose in the dog

Wood, Simon; John, B. A.; Hawkins, David R.

doi:10.1016/s0278-6915(00)00031-4

Cited by 52 publications

(21 citation statements)

References 3 publications

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“…Students should also take into consideration evidence from the study discussed in Questions 4 and 5 where an average of 92.8% of radioactivity from 14 C-sucralose was recovered within 5 days indicating the only metabolism of sucralose in humans involves glucuronidation [4]. These results have been supported by studies in dogs, mice, and rats [15][16][17]. 7) Sucralose is a halogenated compound.…”

mentioning

confidence: 91%

“…Based on this data, a small portion of ingested sucralose appears to be metabolized in humans. 5) Students should look up the structure of glucuronic acid in their class text [7] and draw b-D-glucopyranuronic acid (M1 and M2 were hydrolyzed in the presence of b-glucuronidase) attached from C1 to a hydroxyl group (most likely to the primary hydroxyl group at C6 of the 4-chlorogalactopyranosyl moiety which is the most reactive group) of sucralose [15]. The addition of glucuronic acid increases the polarity of sucralose.…”

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confidence: 99%

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Is sucralose too good to be true?

Thomas

2011

Biochem Molecular Bio Educ

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Student interest in artificial sweeteners can enhance the biochemistry classroom learning experience. This in class, guided-inquiry activity focuses on sucralose and fits into a 50-min biochemistry class for undergraduate science majors. Background knowledge of carbohydrate structure, function, and metabolism as well as familiarity with interpretation of primary literature is assumed. This activity uses short answer questions that stimulate small group discussion.

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confidence: 91%

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confidence: 99%

Is sucralose too good to be true?

Thomas

2011

Biochem Molecular Bio Educ

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“…Pharmacokinetic studies carry out in different animal species and in human beings have showed that sucralose presents limited absorption, rapid urinary excretion, fecal excretion of unchanged sucralose, and minimal metabolism MEDICINAL CHEMISTRY RESEARCH of the absorbed material with no bioaccumulation John et al, 2000a;Roberts et al, 2000;Wood et al, 2000). Sucralose is not hydrolyzed in the intestinal lumen, poorly absorbed, and an elimination profile in humans similar to those found in the rat, rabbit, dog, and mouse John et al, 2000a, b;Wood et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Sucralose sweetener does not modify radiolabeling of blood constituents and morphology of red blood cells

et al. 2011

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Effects of sucralose on the labeling of blood constituents with technetium-99m ( 99m Tc) and on the morphology of red blood cells (RBC) were evaluated. Blood samples from Wistar rats were treated with sweetener, and the labeling of blood constituents with ( 99m Tc) was performed. Radioactivity in blood constituents was counted, and the percentage of incorporated radioactivity (%ATI) was determined. Blood smears were prepared for morphology evaluation of RBC. No significant alterations in %ATI of blood constituents and morphology of RBC were observed.

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“…Consistent with regulatory requirements, the core safety research studies for sucralose were designed and conducted in accordance with recognized international standards. Critical safety studies are available in the following publications (Finn and Lord, 2000;Grice and Goldsmith, 2000;John et al, 2000a,b;Kille et al, 2000a,b;Mann et al, 2000a,b;Mc Lean Baird et al, 2000;Roberts et al, 2000;Sims et al, 2000;Wood et al, 2000). Examples of studies conducted included, but were not limited to:…”

Section: Microconstituents In the Marinementioning

confidence: 99%

“…Glucuronide conjugates are also excreted in urine and readily eliminated with no measurable bioaccumulation (Grice andGoldsmith, 2000 John et al, 2000a;McLean Baird et al, 2000;Roberts et al, 2000;Sims et al, 2000;Wood et al, 2000). In addition to being extremely stable and virtually unaltered by human metabolic processes, sucralose proved to be stable under bacterial metabolism.…”

Section: Microconstituents In the Marinementioning

confidence: 99%

Sucralose : a unique tracer for wastewater intrusion

Cejas¹

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The vitality of the Florida Keys ecosystem has been impacted by various anthropogenic influences, whereas one of the significant influences is the local intrusion of untreated wastewater. Prior research has elucidated the unique stability of sucralose under human and microbial metabolic processes and low decay rates in water, sediment, soil and sewage compartments. The unique environmental stability of sucralose and its specificity to anthropogenic sources, served as a basis to assess it as an ideal molecular tracer for wastewater intrusion. This study presents the development and validation of two isotope dilution methods, sucralose i.e. Splenda®. One method applied ESI-LC-MSMS, while the other employed (GC-MS). Sucralose was discovered to be an ideal tracer occurring at higher concentrations than previously detected pollutants in the chosen study sites. Furthermore, the accuracy, precision and detection limits of both analytical methods were suitable for the environmental monitoring in coastal marine waters of the Florida Keys.

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The pharmacokinetics and metabolism of sucralose in the dog

Cited by 52 publications

References 3 publications

Is sucralose too good to be true?

Is sucralose too good to be true?

Sucralose sweetener does not modify radiolabeling of blood constituents and morphology of red blood cells

Sucralose : a unique tracer for wastewater intrusion

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