The pharmacokinetic study on the mechanism of toxicity attenuation of rhubarb total free anthraquinone oral colon-specific drug delivery system

Zhang, Lin; Chang, Jinhua; Zhang, Bao‐Qi; Xigang, Liu; Liu, Pei; Xue, He-fei; Liu, Liyan; Fu, Qiang; Zhu, Meng; Cui-zhe, Liu

doi:10.1016/j.fitote.2015.05.018

Cited by 30 publications

(20 citation statements)

References 5 publications

(8 reference statements)

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“…Similarly, oral administration of rhein showed no effect on tissue distributions, but affected the absorption (van Gorkom et al, ). Zhang et al () reported that oral gavage of rhubarb at 340 mg/kg bw showed remnant plasma levels of aloe‐emodin (0.67 μM), rhein (0.5 μM), emodin (0.7 μM), and chrysophanol (0.5 μM). This indicates that the postconsumption levels of most AQs mainly exist in plasma as conjugates.…”

Section: Resultsmentioning

confidence: 99%

Antidiabetic potential of anthraquinones: A review

Mohammed

Ibrahim

Tajuddeen

et al. 2019

Phytotherapy Research

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The present study was designed to review the antidiabetic potential of anthraquinones (AQs) with emphasis on the extent of blood glucose reduction, the half maximal inhibitory concentration values (in vitro studies), the proposed mechanisms of action, and the structure activity relationship studies. We sourced relevant data from the major scientific databases (Pubmed, Science Direct, Medline, and Google Scholar). According to our search, 25 AQs have shown variable antidiabetic potential, whereas one AQ (morindone‐6‐O‐β‐D‐primeveroside) showed no blood glucose‐lowering ability. Emodin and rhein showed the most promising antidiabetic potential in various models. The proposed mechanisms of antidiabetic action include upregulation of insulin receptor substrates‐1, phosphoinositide‐3‐kinase, and Akt‐ser473 expression and elevation of glucagon‐like peptide‐1 level in diabetic animal models linked to the potent protein tyrosine phosphatase 1B and dipeptidyl peptidase‐4 inhibitions. In addition, activation of peroxisome proliferator‐activated receptors gamma and inhibition of α‐glucosidase activity are other possible targets proposed as the mechanism of AQs antidiabetic action. The position and the number of hydroxyl group showed great influence on the overall antidiabetic potential of AQs. AQs hold promising antidiabetic activity despite scanty information. We hope that the present study will serve as a template to further explore the antidiabetic potential of AQs and subsequent antidiabetic drug development.

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Section: Resultsmentioning

confidence: 99%

Antidiabetic potential of anthraquinones: A review

Mohammed

Ibrahim

Tajuddeen

et al. 2019

Phytotherapy Research

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“…In another study, quercetin, the active phenolic component in kiwifruit, mediated by its free radical-scavenging activity, prevented hydrogen peroxideinduced inhibition of gap-junction intercellular communication in rat liver epithelial cells that is required for cell-cell communication in order to maintain homeostasis by facilitating direct exchanges of essential cellular metabolites and messengers less than 1-2 kDa (e.g. , cyclic AMP and ATP) [165][166][167]. Additionally, quercetin possesses chemopreventive activity against azoxymethane-induced colonic tumorigenesis in mice and pre-neoplastic lesions in rat hepatocarcinogenesis [167].…”

Section: Phenols and Phenolic Acidsmentioning

confidence: 98%

“…, cyclic AMP and ATP) [165][166][167]. Additionally, quercetin possesses chemopreventive activity against azoxymethane-induced colonic tumorigenesis in mice and pre-neoplastic lesions in rat hepatocarcinogenesis [167].…”

Section: Phenols and Phenolic Acidsmentioning

confidence: 99%

Medicinal Potentials and Toxicity Concerns of Bioactive Principles

CO¹

2015

Med Aromat Plants

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“…However, due to the high first pass metabolism and greater hydrophobicity of emodin, it cannot be efficiently delivered through oral means, limiting the bioavailability and bioaccessibility of the compound. [163][164][165][166][167][168][169] A novel delivery approach was carried out using various delivery technologies, including nanoemulsions and nanotransfers, and some showed efficient delivery of emodin through oral means, which in turn enhances its efficacy. Recently, emodin-loaded magnesium hollow silicate nanocarriers were studied for their efficacy in treating angiogenesis associated with diabetic retinopathy.…”

Section: Nano-emodinmentioning

confidence: 99%

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status

Ganesan¹,

Arulselvan²,

Choi³

2017

IJN

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Type 2 diabetes mellitus (T2DM) is a major chronic disease that is prevalent worldwide, and it is characterized by an increase in blood glucose, disturbances in the metabolism, and alteration in insulin secretion. Nowadays, food-based therapy has become an important treatment mode for type 2 diabetes, and phytobioactive compounds have gained an increasing amount of attention to this end because they have an effect on multiple biological functions, including the sustained secretion of insulin and regeneration of pancreatic islets cells. However, the poor solubility and lower permeability of these phyto products results in a loss of bioactivity during processing and oral delivery, leading to a significant reduction in the bioavailability of phytobioactive compounds to treat T2DM. Recently, nanotechnological systems have been developed for use as various types of carrier systems to improve the delivery of bioactive compounds and thus obtain a greater bioavailability. Furthermore, carrier systems in most nanodelivery systems are highly biocompatible, with nonimmunologic behavior, a high degree of biodegradability, and greater mucoadhesive strength. Therefore, this review focuses on the various types of nanodelivery systems that can be used for phytobioactive compounds in treating T2DM with greater antidiabetic effects. There is also additional focus on improving the effects of various phytobioactive compounds through nanotechnological delivery to ensure a highly efficient treatment of type 2 diabetes.

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The pharmacokinetic study on the mechanism of toxicity attenuation of rhubarb total free anthraquinone oral colon-specific drug delivery system

Cited by 30 publications

References 5 publications

Antidiabetic potential of anthraquinones: A review

Antidiabetic potential of anthraquinones: A review

Medicinal Potentials and Toxicity Concerns of Bioactive Principles

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status

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The pharmacokinetic study on the mechanism of toxicity attenuation of rhubarb total free anthraquinone oral colon-specific drug delivery system

Cited by 30 publications

References 5 publications

Antidiabetic potential of anthraquinones: A review

Antidiabetic potential of anthraquinones: A review

Medicinal Potentials and Toxicity Concerns of Bioactive Principles

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus &ndash; current status

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Product

Resources

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Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status