The Pharmacodynamics of Vecuronium in Chronic Renal Failure Patients: The Impact of Different Priming Doses

Tarbeeh, Gehan A.; Othman, Mahmoud M.

doi:10.3109/0886022x.2012.684552

Cited by 2 publications

(1 citation statement)

References 38 publications

(43 reference statements)

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“…Vecuronium is a non-depolarising neuromuscular blocking drug, which has minimal cardiovascular effects and lack of dependence on the kidney for elimination (1). But it has a disadvantage of having a relatively slow onset time, around 2-3 minutes with 0.1 mg/kg dose of vecuronium.…”

Section: Introductionmentioning

confidence: 99%

Randomized Double Blind Controlled Study Comparing Vecuronium Priming, Magnesium Pretreatment and Combination of the Two Methods on the Onset of Intubating Conditions

2015

IJSR

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Introduction: Priming markedly shortens the onset time to non depolarising neuromuscular blocking drugs. Magnesium inhibits presynaptic acetylcholine release at the motor end plate; hence magnesium potentiates the effect of non-depolarising muscle relaxants and shortens their onset time. Thus, the combination of priming and magnesium pre-treatment may be an alternative, effective method for accomplishing early tracheal intubation. We investigated whether magnesium sulphate with vecuronium priming shortens the onset of neuromuscular blockade, compared with these methods used alone. Materials and Methods: 100 patients undergoing elective surgical procedures under general anaesthesia were randomized into group N (n = 25) were given 0.1mg/kg vecuronium, group V (n=25) were primed with 0.01 mg/kg vecuronium three minutes before a further dose of 0.09 mg/kg vecuronium, group M (n=25) were given an infusion of 50 mg/kg magnesium sulphate before vecuronium, group MV (n=25) were given both the magnesium sulphate and the priming dose of vecuronium. Trachea was intubated when the TOF stimulus showed only one twitch measured at intervals of 30 seconds. The time to onset of neuromuscular blockade, duration of blockade and tracheal intubating conditions were measured. Results: The magnesium and prime group had the shortest mean (SD) onset time 112.80 (19.89) sec (p < 0.001) compared to the other groups. The duration of blockade was prolonged in both Group M and Group MV (P < 0.001). Few adverse effects were reported in magnesium preloaded group, clinically not significant. Conclusion: The combination of magnesium sulphate and vecuronium priming accelerated the onset of neuromuscular blockade compared with either magnesium sulphate or priming used alone.

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Section: Introductionmentioning

confidence: 99%

Randomized Double Blind Controlled Study Comparing Vecuronium Priming, Magnesium Pretreatment and Combination of the Two Methods on the Onset of Intubating Conditions

2015

IJSR

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The challenges of multiple organ dysfunction syndrome and extra-corporeal circuits for drug delivery in critically ill patients

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et al. 2014

Advanced Drug Delivery Reviews

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The Pharmacodynamics of Vecuronium in Chronic Renal Failure Patients: The Impact of Different Priming Doses

Abstract: Priming the chronic renal failure patients with 10% of ED(95) vecuronium dose acquit the best pharmacodynamics with the fewest signs of muscle weakness. Larger vecuronium priming doses are unfavorable and convey no more clinical utility.

Cited by 2 publications

References 38 publications

Randomized Double Blind Controlled Study Comparing Vecuronium Priming, Magnesium Pretreatment and Combination of the Two Methods on the Onset of Intubating Conditions

Randomized Double Blind Controlled Study Comparing Vecuronium Priming, Magnesium Pretreatment and Combination of the Two Methods on the Onset of Intubating Conditions

The challenges of multiple organ dysfunction syndrome and extra-corporeal circuits for drug delivery in critically ill patients

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