Abstract:Background and objective: Neuromuscular blocking effects according to the severity of liver dysfunction have not been evaluated. We assessed the neuromuscular effects of mivacurium in carbon tetrachloride (CCl 4 )-treated rabbits with toxic hepatitis in vivo. Methods: We compared the dose-response relationships and the neuromuscular blocking effects of mivacurium in 66 rabbits randomly treated with 0.3 mL kg 21 of corn oil, 0.3 mL kg 21 of CCl 4 or 0.6 mL kg 21 of CCl 4 for 11 weeks, respectively. Train-of-fou… Show more
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